Sodium Channel in Cardiovascular Diseases and Health
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 1340
Special Issue Editors
Interests: cardiac arrhythmias; electrical coupling; cardiopulmonary resuscitation
Special Issue Information
Dear Colleagues,
Voltage-gated sodium channels play a crucial role in cardiovascular physiology, especially regulating the initiation and propagation of electrical impulses in excitable cells. They are composed of a pore-forming α subunit and two auxiliary β subunits. They are categorized into tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels. TTX-sensitive solidum channels such as Nav1.1–1.3 and Nav1.6 are commonly located in the brain, while TTX-resistant sodium channels, mainly Nav1.5, are located in the heart. However, in recent years, it has been clear that some TTX-sensitive sodium channels are also located in the heart and play important roles in maintaining normal cardiac electrical propagation. Sodium channels have been involved in many cardiovascular diseases, including heart failure, ischemic heart disease, atrial fibrillation, pulmonary arterial hypertension and inherited cardiac diseases such as Long QT Syndrome and Brugada Syndrome.
This Special Issue of the International Journal of Molecular Sciences aims to provide a comprehensive overview of the current knowledge on sodium channels in cardiovascular disease and new insights into their underlying molecular mechanisms, clinical implications and potential therapeutic strategies in cardiovascular diseases.
Dr. Xiaobo Wu
Dr. Xianming Lin
Guest Editors
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Keywords
- sodium channels
- cardiac conduction
- physiology
- mechanisms
- tetrodoxoxin
- action potential