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Editorial Board Members’ Collection Series: “Emerging Progress in Nanomedicine”

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 1009

Special Issue Editors


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Guest Editor
Department of Biology, Center Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA
Interests: drug delivery; nanovesicles; non-alcoholic fatty liver; intestinal inflammation

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Guest Editor
Department of Neurosciences, University of Turin, 10126 Turin, Italy
Interests: magnetic nanoparticles and nanoparticles functionalization; acceleration methods for MRI acquisition and reconstruction; neuroimaging and non-invasive brain stimulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce this Special Issue collection titled “Editorial Board Members’ Collection Series: “Emerging Progress in Nanomedicine””. This Issue aims to collect high-quality research articles, short communications, and review articles in all fields of nanomedicine. We encourage the Editorial Board Members of the International Journal of Molecular Sciences and researchers invited by the Editorial Board Members to contribute papers reflecting the latest progress in their research field.

Topics include, but are not limited to, the following:

  • Nanomedicine in brain disease therapy;
  • Nanomedicine in cancer targeting and therapy;
  • Nanomedicine in cardiovascular diseases therapy;
  • Targeted delivery of nanodrug;
  • Nanodrug design and synthesis;
  • Immunomodulatory nanomedicine;
  • Bioactive nanomaterials;
  • Nanotoxicology.

Dr. Hamed Laroui
Dr. Federico D’Agata
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomedicine
  • nanoparticles
  • nanotechnology
  • targeted drug delivery
  • pharmaceutical nanoimaging
  • nanoengineering
  • nanotoxicology

Published Papers (1 paper)

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Research

17 pages, 2809 KiB  
Article
Developing Iron Nanochelating Agents: Preliminary Investigation of Effectiveness and Safety for Central Nervous System Applications
by Eleonora Ficiarà, Chiara Molinar, Silvia Gazzin, Sri Jayanti, Monica Argenziano, Lucia Nasi, Francesca Casoli, Franca Albertini, Shoeb Anwar Ansari, Andrea Marcantoni, Giulia Tomagra, Valentina Carabelli, Caterina Guiot, Federico D’Agata and Roberta Cavalli
Int. J. Mol. Sci. 2024, 25(2), 729; https://doi.org/10.3390/ijms25020729 - 5 Jan 2024
Cited by 1 | Viewed by 813
Abstract
Excessive iron levels are believed to contribute to the development of neurodegenerative disorders by promoting oxidative stress and harmful protein clustering. Novel chelation treatments that can effectively remove excess iron while minimizing negative effects on the nervous system are being explored. This study [...] Read more.
Excessive iron levels are believed to contribute to the development of neurodegenerative disorders by promoting oxidative stress and harmful protein clustering. Novel chelation treatments that can effectively remove excess iron while minimizing negative effects on the nervous system are being explored. This study focuses on the creation and evaluation of innovative nanobubble (NB) formulations, shelled with various polymers such as glycol-chitosan (GC) and glycol-chitosan conjugated with deferoxamine (DFO), to enhance their ability to bind iron. Various methods were used to evaluate their physical and chemical properties, chelation capacity in diverse iron solutions and impact on reactive oxygen species (ROS). Notably, the GC-DFO NBs demonstrated the ability to decrease amyloid-β protein misfolding caused by iron. To assess potential toxicity, in vitro cytotoxicity testing was conducted using organotypic brain cultures from the substantia nigra, revealing no adverse effects at appropriate concentrations. Additionally, the impact of NBs on spontaneous electrical signaling in hippocampal neurons was examined. Our findings suggest a novel nanochelation approach utilizing DFO-conjugated NBs for the removal of excess iron in cerebral regions, potentially preventing neurotoxic effects. Full article
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