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Effects of Nutrients, Dietary Components, and Functional Food on Immune...
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Effects of Nutrients, Dietary Components, and Functional Food on Immune and Inflammatory Responses

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (29 December 2022) | Viewed by 3773

Special Issue Editors

Prof. Dr. Wen-Hsing Cheng

E-Mail Website
Guest Editor
Department of Food Science, Nutrition and Health Promotion, College of Agriculture and Life Science, Mississippi State University, Mississippi State, MS 39762, USA
Interests: selenium; aging; geroscience; selenoprotein; genome stability
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Huawei Zeng

E-Mail Website
Guest Editor
USDA ARS Grand Forks Human Nutrition Research Center, Grand Forks, ND, USA
Interests: genetic variation on optimal nutritional intake; molecular mechanisms of cancer-preventive nutrients

Special Issue Information

Dear Colleagues, 

Abnormal inflammatory responses have been implicated in various diseases, including cancer, diabetes, arthritis, cardiovascular diseases, bowel diseases, and infectious diseases. A defective immune system also occurs in some inflammatory diseases such as type 1 diabetes and rheumatoid arthritis. Immune and inflammatory responses are activated to protect against a health condition. The body responds to pathogenic inflammation by coordinated activation of signaling pathways in tissues and circulation. Likewise, the immune system protects the host against pathogenic microbiomes, toxic substances, and allergens through innate and adaptive mechanisms. Although immune and inflammatory responses are spontaneous responses in healthy individuals, they are dysregulated by diseases, age, and environmental factors. Nutrients, dietary components, and functional food can modulate these responses for optimal health.

This Special Issue welcomes submissions concerning any aspect of nutritional protection against inflammatory diseases.

Prof. Dr. Wen-Hsing Cheng
Dr. Huawei Zeng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • microbiome
  • cancer
  • nutrition or nutrients or diet
  • nutrient
  • functional food
  • immunity
  • inflammation
  • chronic disease
  • age

Published Papers (2 papers)

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Research

16 pages, 29748 KiB  
Article
Different Regulatory Effects of Heated Products and Maillard Reaction Products of Half-Fin Anchovy Hydrolysates on Intestinal Antioxidant Defense in Healthy Animals
by Min Shi, Ru Song and Luo Gu
Int. J. Mol. Sci. 2023, 24(3), 2355; https://doi.org/10.3390/ijms24032355 - 25 Jan 2023
Cited by 1 | Viewed by 1232
Abstract
The oxidative state of intestinal tracts of healthy animals were investigated after short-term intake of half-fin anchovy hydrolysates (HAHp) and their thermal or Maillard reaction products (MRPs). After one month of continuous oral gavage of HAHp, HAHp-heated products (HAHp-H), the MRPs of HAHp [...] Read more.
The oxidative state of intestinal tracts of healthy animals were investigated after short-term intake of half-fin anchovy hydrolysates (HAHp) and their thermal or Maillard reaction products (MRPs). After one month of continuous oral gavage of HAHp, HAHp-heated products (HAHp-H), the MRPs of HAHp with 3% of glucose (HAHp-3%G MRPs), and the MRPs of HAHp with 3% of fructose (HAHp-3%F MRPs) at a dose of 1.0 g/kg of body weight per day into healthy ICR male mice, the concentrations of serum low-density and high-density lipoprotein cholesterol did not significantly change compared to the control group (CK, gavage with saline). Similar results were found for the interleukin-6 concentrations of all groups. By comparison, HAHp-H, HAHp-3%G MRPs, and HAHp-3%F MRPs administration decreased serum tumor necrosis factor-α concentration as compared to the CK group (p < 0.05). No histological damage was observed in the jejunum, ileum, and colonic tissues of all groups. However, HAHp-H treatment induced higher upregulation of Kelch-like ECH-associated protein 1, transcription factors Nrf-2, associated protective phase-II enzymes of NAD(P)H: quinine oxidoreductase-1, and hemoxygenase-1 in colon tissue, as well as higher upregulation of endogenous antioxidant enzymes, including copper/zinc superoxide dismutase, manganese superoxide dismutase, catalase, and glutathione peroxidase 2 than other groups (p < 0.05). Additionally, increases in Nε-carboxymethyllysine expression in the colonic tissues of all groups were consistent with their increased oligopeptide transporter 1 expressions. Our results suggest that the thermal products of HAHp might have a broad application prospect in improving antioxidant defense in vivo in healthy animals. Full article
(This article belongs to the Special Issue Effects of Nutrients, Dietary Components, and Functional Food on Immune and Inflammatory Responses)
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18 pages, 5450 KiB  
Article
Glycine Nano-Selenium Enhances Immunoglobulin and Cytokine Production in Mice Immunized with H9N2 Avian Influenza Virus Vaccine
by Zhihua Ren, Samuel Kumi Okyere, Ming Zhang, Xin Zhang, Hongxuan He and Yanchun Hu
Int. J. Mol. Sci. 2022, 23(14), 7914; https://doi.org/10.3390/ijms23147914 - 18 Jul 2022
Cited by 4 | Viewed by 1970
Abstract
This study was performed to investigate the immune enhancement effect of glycine nano-selenium, a microelement on H9N2 avian influenza virus vaccine (H9N2 AIV vaccine) in mice. Fifty (50) Specific Pathogen Free Kunming mice aged 4–6 weeks (18–20 g Body weight) were randomly divided [...] Read more.
This study was performed to investigate the immune enhancement effect of glycine nano-selenium, a microelement on H9N2 avian influenza virus vaccine (H9N2 AIV vaccine) in mice. Fifty (50) Specific Pathogen Free Kunming mice aged 4–6 weeks (18–20 g Body weight) were randomly divided into five groups: control normal group, which received no immunization + 0.5 mL 0.9% normal saline, positive control group, which received H9N2 AIV vaccine + 0.5 mL 0.9% normal saline, 0.25 mg/kg selenium group, which received H9N2 AIV vaccine + 0.5 mL 0.25 mg/kg selenium solution, 0.5 mg/kg selenium group, which received H9N2 AIV vaccine + 0.5 mL 0.5 mg/kg selenium solution, and 1 mg/kg selenium group, which received H9N2 AIV vaccine + 0.5 mL 1 mg/kg selenium solution. Hematoxylin and eosin staining, enzyme linked immunosorbent assay (ELISA), and quantitative real time polymerase chain reaction (qRT-PCR) methods were used to investigate the pathological changes, immunoglobulin levels, and cytokine gene expressions in this study. The results showed that all tested doses (0.25 mg/kg, 0.5 mg/kg and 1.00 mg/kg) of glycine nano-selenium did not lead to poisoning in mice. In addition, when compared to the positive control group, glycine nano-selenium increased the immunoglobin indexes (IgA, IgG, IgM and AIV-H9 IgG in serum) as well as the mRNA levels of IL-1β, IL-6 and INF-γ in the liver, lungs, and spleen (p < 0.05). In summary, glycine nano-selenium could enhance the efficacy of avian influenza vaccine. Full article
(This article belongs to the Special Issue Effects of Nutrients, Dietary Components, and Functional Food on Immune and Inflammatory Responses)
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