Inflammation and Oxidative Stress in Kidney Disease 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 3631
Special Issue Editor
Interests: triple negative breast cancer (TNBC); modulated-electrohyperthermia (mEHT); ischemia induced acute kidney injury (IRI-AKI); non-coding RNAs (miRNA, siRNA, lncRNA); the role of fibrinogen in cell stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
Ischemia-reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). IRI can lead to renal transplantation as well as circulatory and septic shock. Moreover, it contributes to contrast-induced nephropathy and can lead to chronic kidney disease in the long term. The initial injury is aggravated by subsequent inflammation due to the deliberation of danger-associated molecular patterns (DAMP) and their recognition via toll-like receptors (TLRs). TLRs activate the inflammasome, the interferon (IFN) response, and the subsequent cytokine release initiates inflammation associated with oxidative stress. Cell death is primarily necrotic during ischemia, but tissue damage due to necroptosis or apoptosis occurs during reperfusion. Bacterial endotoxin (lipopolysaccharide)-induced immune-paralysis can provide protection from an otherwise lethal ischemic injury; however, the molecular mechanisms of this cross-tolerance are largely unknown.
An increasing body of evidence suggests that these processes are regulated or modulated by non-coding RNAs (lncRNA, miRNA) and thus can be therapeutically influenced by RNA-based therapies (mRNA, siRNA, ASO). The role of miR-21 has been already well established in disease states, but influencing miR-21 expression did not provide the expected clinical benefit. New miRs and lncRNAs are emerging as potential therapeutic tools to reduce reperfusion injury and chronic kidney disease.
Dr. Peter Hamar
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
