Molecular Study of Renal Diseases

Dear Colleagues,

Chronic kidney disease (CKD) is progressively increasing in incidence and represents an important economic burden for health systems and a significant discomfort for patients, often leading to end-stage kidney disease (ESKD) whose only therapeutic approaches are still represented by renal replacement therapies (RRTs). To help slowing down the progression of CKD and the comprehension of the underlying mechanisms leading to ESKD the application of alternative computational, digital and omic tools represents an invaluable resource applicable on different media (renal biopsy, blood, urine) to unveil the pathobiological basis of renal diseases. This can prompt (1) the detection of new diagnostic, prognostic and predictive biomarkers easily translatable to the clinical practice, (2) detect new putative targets for innovative therapies in the precision medicine direction and (3) understand the molecular modifications leading to the perturbation of renal homeostasis.

In this setting, we are opening the invitation to submit your research in this Special Issue, entitled "Computational, Digital and Spatial Biology Tools for the Study of Renal Diseases", which aims to provide a research platform for the collection of original research articles and the latest reviews which cover all molecular aspects of kidney diseases.

Dr. Giulia Capitoli
Dr. Vincenzo L'Imperio
Dr. Michele Provenzano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• digital pathology
• computational pathology
• spatial biology
• renal biopsy
• chronic kidney disease

Planned Paper I: Kidney diseases and cardiovbascular disease, involving vitamin K deficiency, matrix gla protein and pulse wave velocity

Planned Paper II: The Mathematical Analysis of the Contrast-Enhanced CT of the Kidneys in the Patients with Urolithiasis