Cellular and Molecular Research of Kidney Diseases 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 3411
Special Issue Editor
Interests: cardiovascular and renal diseases; inflammation; fibrosis; growth factor; molecular mechanism; novel therapeutic targets
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic kidney disease (CKD) represents a wide variety of diseases with different etiologies, including immunological, metabolic, genetic, vascular or mechanical-related complications, as well as an age-related disorder. CKD is the 5th predicted global cause of death by 2040, the fastest increase among major causes of death, after Alzheimer, revealing the importance of research in this area. Current CKD therapies are limited to harsh immunosuppression in some fast progressive diseases, as immune glomerulonephritis, as well as drugs blocking the renin angiotensin system aimed to control systemic blood pressure. Although, recent trials have reported promising results with SGLT2 inhibition, the majority of CKD patients still progress towards end-stage renal damage (ESRD) requiring renal replacement therapies, such as dialysis or transplantation.
Intensive research in this area includes investigation of cellular communication, phenotype changes, including those related to senescent phenotypes, novel mediators of kidney injury, epigenetic mechanisms, activation of signaling pathways, among others, showing the complexity of this field. Strategies to target resident glomerular or tubular damage, as well as immune cells have been proposed to ameliorate disease progression or even revert kidney damage. In spite of all available data, translation of new research into novel therapies in CKD is greatly lagging behind other disciplines.
We invite you to submit novel research about molecular and cellular mechanisms involved in kidney injury.
Prof. Dr. Marta Ruiz-Ortega
Guest Editor
Manuscript Submission Information
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