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Interaction of Nanomaterials with the Immune System 3.0

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (15 May 2024) | Viewed by 3091

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Special Issue Editor

Dr. Rob J. Vandebriel

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Guest Editor

Centre for Health Protection, National Institute of Public Health & Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands
Interests: immunotoxicology; nanotoxicology; innate immune response to vaccines; inflammasome; dendritic cells; macrophages
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanomaterials can affect the immune system, which may lead to its reduced functioning, with possible consequences of reduced resistance to infections and tumors and inflammatory, allergic, and autoimmune reactions. Inflammation resulting from nanomaterial exposure has gained significant interest, with (chronic) inflammation giving rise to fibrosis in organs such as lung and liver and leading to chronic inflammatory diseases. For nanomedicines, strategies are being developed to determine their safety and efficacy; here, effects on the immune system are considered important. Advanced materials are increasingly used in medical devices; understanding the immune system’s response to these materials is essential to evaluate their safety. By taking up nanomaterials, immune cells affect their biodistribution; understanding the immune system’s role is crucial to interpret nanomaterial biodistribution. Nanomaterials affect resistance to infections, both directly through affecting the cellular uptake of bacteria and viruses and indirectly by affecting the microbiome. We welcome submissions on this topic, including original papers and reviews.

Dr. Rob J. Vandebriel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

nanomaterials
nanoparticles
nanomedicines
immune system
infection
inflammation
allergy
autoimmunity

Related Special Issues

Interaction of Nanomaterials with the Immune System in International Journal of Molecular Sciences (12 articles)
Interaction of Nanomaterials with the Immune System 2.0 in International Journal of Molecular Sciences (23 articles)

Published Papers (4 papers)

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Research

12 pages, 541 KiB

Open AccessCommunication

Nano(bio)Materials Do Not Affect Macrophage Phenotype—A Study Conducted by the REFINE Project

by Christopher A. W. David, Jolanda P. Vermeulen, Sabrina Gioria, Rob J. Vandebriel and Neill J. Liptrott

Int. J. Mol. Sci. 2024, 25(10), 5491; https://doi.org/10.3390/ijms25105491 - 17 May 2024

Abstract

Macrophagesare well known for their involvement in the biocompatibility, as well as biodistribution, of nano(bio)materials. Although there are a number of rodent cell lines, they may not fully recapitulate primary cell responses, particularly those of human cells. Isolation of tissue-resident macrophages from humans is difficult and may result in insufficient cells with which to determine the possible interaction with nano(bio)materials. Isolation of primary human monocytes and differentiation to monocyte-derived macrophages may provide a useful tool with which to further study these interactions. To that end, we developed a standard operating procedure for this differentiation, as part of the Regulatory Science Framework for Nano(bio)material-based Medical Products and Devices (REFINE) project, and used it to measure the secretion of bioactive molecules from M1 and M2 differentiated monocytes in response to model nano(bio)materials, following an initial assessment of pyrogenic contamination, which may confound potential observations. The SOP was deployed in two partner institutions with broadly similar results. The work presented here shows the utility of this assay but highlights the relevance of donor variability in responses to nano(bio)materials. Whilst donor variability can provide some logistical challenges to the application of such assays, this variability is much closer to the heterogeneous cells that are present in vivo, compared to homogeneous non-human cell lines. Full article

(This article belongs to the Special Issue Interaction of Nanomaterials with the Immune System 3.0)

15 pages, 2829 KiB

Open AccessArticle

In Vivo Pro-Inflammatory Effects of Silver Nanoparticles on the Colon Depend on Time and Route of Exposure

by Wojciech Grodzicki, Katarzyna Dziendzikowska, Joanna Gromadzka-Ostrowska, Jacek Wilczak, Michał Oczkowski, Łukasz Kopiasz, Rafał Sapierzyński, Marcin Kruszewski and Agnieszka Grzelak

Int. J. Mol. Sci. 2024, 25(9), 4879; https://doi.org/10.3390/ijms25094879 - 30 Apr 2024

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Abstract

Nanosilver is a popular nanomaterial, the potential influence of which on humans is of serious concern. Herein, we exposed male Wistar rats to two regimens: a repeated oral dose of 30 mg/kg bw silver nanoparticles (AgNPs) over 28 days and a single-dose injection of 5 mg/kg bw of AgNPs. At three different time points, we assessed antioxidant defense, oxidative stress and inflammatory parameters in the colon, as well as toxicity markers in the liver and plasma. Both experimental scenarios showed increased oxidative stress and inflammation in the colon. Oral administration seemed to be linked to increased reactive oxygen species generation and lipid peroxidation, while the effects induced by the intravenous exposure were probably mediated by silver ions released from the AgNPs. Repeated oral exposure had a more detrimental effect than the single-dose injection. In conclusion, both administration routes had a similar impact on the colon, although the underlying mechanisms are likely different. Full article

(This article belongs to the Special Issue Interaction of Nanomaterials with the Immune System 3.0)

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Graphical abstract

31 pages, 4522 KiB

Open AccessArticle

Toxicity of Metal Oxide Nanoparticles: Looking through the Lens of Toxicogenomics

by Andrey Boyadzhiev, Dongmei Wu, Mary-Luyza Avramescu, Andrew Williams, Pat Rasmussen and Sabina Halappanavar

Int. J. Mol. Sci. 2024, 25(1), 529; https://doi.org/10.3390/ijms25010529 - 30 Dec 2023

Cited by 1 | Viewed by 874

Abstract

The impact of solubility on the toxicity of metal oxide nanoparticles (MONPs) requires further exploration to ascertain the impact of the dissolved and particulate species on response. In this study, FE1 mouse lung epithelial cells were exposed for 2–48 h to 4 MONPs of varying solubility: zinc oxide, nickel oxide, aluminum oxide, and titanium dioxide, in addition to microparticle analogues and metal chloride equivalents. Previously published data from FE1 cells exposed for 2–48 h to copper oxide and copper chloride were examined in the context of exposures in the present study. Viability was assessed using Trypan Blue staining and transcriptomic responses via microarray analysis. Results indicate material solubility is not the sole property governing MONP toxicity. Transcriptional signaling through the ‘HIF-1α Signaling’ pathway describes the response to hypoxia, which also includes genes associated with processes such as oxidative stress and unfolded protein responses and represents a conserved response across all MONPs tested. The number of differentially expressed genes (DEGs) in this pathway correlated with apical toxicity, and a panel of the top ten ranked DEGs was constructed (Hmox1, Hspa1a, Hspa1b, Mmp10, Adm, Serpine1, Slc2a1, Egln1, Rasd1, Hk2), highlighting mechanistic differences among tested MONPs. The HIF-1α pathway is proposed as a biomarker of MONP exposure and toxicity that can help prioritize MONPs for further evaluation and guide specific testing strategies. Full article

(This article belongs to the Special Issue Interaction of Nanomaterials with the Immune System 3.0)

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20 pages, 5699 KiB

Open AccessArticle

Differences in Physico-Chemical Properties and Immunological Response in Nanosimilar Complex Drugs: The Case of Liposomal Doxorubicin

by Dorelia Lipsa, Davide Magrì, Giacomo Della Camera, Rita La Spina, Claudia Cella, Irantzu Garmendia-Aguirre, Dora Mehn, Ana Ruiz-Moreno, Francesco Fumagalli, Luigi Calzolai and Sabrina Gioria

Int. J. Mol. Sci. 2023, 24(17), 13612; https://doi.org/10.3390/ijms241713612 - 2 Sep 2023

Viewed by 1305

Abstract

This study aims to highlight the impact of physicochemical properties on the behaviour of nanopharmaceuticals and how much carrier structure and physiochemical characteristics weigh on the effects of a formulation. For this purpose, two commercially available nanosimilar formulations of Doxil and their respective carriers were compared as a case study. Although the two formulations were “similar”, we detected different toxicological effects (profiles) in terms of in vitro toxicity and immunological responses at the level of cytokines release and complement activation (iC3b fragment), that could be correlated with the differences in the physicochemical properties of the formulations. Shedding light on nanosimilar key quality attributes of liposome-based materials and the need for an accurate characterization, including investigation of the immunological effects, is of fundamental importance considering their great potential as delivery system for drugs, genes, or vaccines and the growing market demand. Full article

(This article belongs to the Special Issue Interaction of Nanomaterials with the Immune System 3.0)

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