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Translational Research on Leukemia
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Translational Research on Leukemia

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 4746

Special Issue Editor

Prof. Dr. Walter Fiedler

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Guest Editor
Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Interests: acute leukemia; phase 1 clinical studies; translational research
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent decades, considerable progress has been made in the understanding of the pathogenesis of AML. Several oncogenic mutations have been identified, such as IDH1/2, or in the FLT3 receptor, which have resulted in the approval of clinically relevant drugs. The same is true for the Bcl2-dependent apoptotic or the hedgehog pathway. Despite these advances, however, further understanding of the molecular and cellular basis of AML is a prerequisite for the introduction of new therapies into the clinic. This research may include investigations of cytokine pathways, signal transduction and apoptosis, as well as interactions of AML cells with the microenvironment. Clinically relevant observations such as studies on minimal residual disease or observations of therapies targeting the immune system may be reported.

This Special Issue, “Translational Research on Leukemia”, will cover a selection of recent research topics and current review articles in the field of leukemia.

Prof. Dr. Walter Fiedler
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • leukemia
  • cytokine
  • signal transduction
  • apoptosis
  • immune therapy
  • MRD

Published Papers (2 papers)

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Research

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16 pages, 7743 KiB  
Article
Variation in Lipid Species Profiles among Leukemic Cells Significantly Impacts Their Sensitivity to the Drug Targeting of Lipid Metabolism and the Prognosis of AML Patients
by Caroline Lo Presti, Yoshiki Yamaryo-Botté, Julie Mondet, Sylvie Berthier, Denisa Nutiu, Cyrille Botté and Pascal Mossuz
Int. J. Mol. Sci. 2023, 24(6), 5988; https://doi.org/10.3390/ijms24065988 - 22 Mar 2023
Cited by 5 | Viewed by 1627
Abstract
Several studies have linked bad prognoses of acute myeloid leukemia (AML) to the ability of leukemic cells to reprogram their metabolism and, in particular, their lipid metabolism. In this context, we performed “in-depth” characterization of fatty acids (FAs) and lipid species in leukemic [...] Read more.
Several studies have linked bad prognoses of acute myeloid leukemia (AML) to the ability of leukemic cells to reprogram their metabolism and, in particular, their lipid metabolism. In this context, we performed “in-depth” characterization of fatty acids (FAs) and lipid species in leukemic cell lines and in plasma from AML patients. We firstly showed that leukemic cell lines harbored significant differences in their lipid profiles at steady state, and that under nutrient stress, they developed common mechanisms of protection that led to variation in the same lipid species; this highlights that the remodeling of lipid species is a major and shared mechanism of adaptation to stress in leukemic cells. We also showed that sensitivity to etomoxir, which blocks fatty acid oxidation (FAO), was dependent on the initial lipid profile of cell lines, suggesting that only a particular “lipidic phenotype” is sensitive to the drug targeting of FAO. We then showed that the lipid profiles of plasma samples from AML patients were significantly correlated with the prognosis of patients. In particular, we highlighted the impact of phosphocholine and phosphatidyl-choline metabolism on patients’ survival. In conclusion, our data show that balance between lipid species is a phenotypic marker of the diversity of leukemic cells that significantly influences their proliferation and resistance to stress, and thereby, the prognosis of AML patients. Full article
(This article belongs to the Special Issue Translational Research on Leukemia)
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Review

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25 pages, 1161 KiB  
Review
Straight to the Point—The Novel Strategies to Cure Pediatric AML
by Monika Lejman, Izabela Dziatkiewicz and Mateusz Jurek
Int. J. Mol. Sci. 2022, 23(4), 1968; https://doi.org/10.3390/ijms23041968 - 10 Feb 2022
Cited by 9 | Viewed by 2595
Abstract
Although the outcome has improved over the past decades, due to improved supportive care, a better understanding of risk factors, and intensified chemotherapy, pediatric acute myeloid leukemia remains a life-threatening disease, and overall survival (OS) remains near 70%. According to French-American-British (FAB) classification, [...] Read more.
Although the outcome has improved over the past decades, due to improved supportive care, a better understanding of risk factors, and intensified chemotherapy, pediatric acute myeloid leukemia remains a life-threatening disease, and overall survival (OS) remains near 70%. According to French-American-British (FAB) classification, AML is divided into eight subtypes (M0–M7), and each is characterized by a different pathogenesis and response to treatment. However, the curability of AML is due to the intensification of standard chemotherapy, more precise risk classification, improvements in supportive care, and the use of minimal residual disease to monitor response to therapy. The treatment of childhood AML continues to be based primarily on intensive, conventional chemotherapy. Therefore, it is essential to identify new, more precise molecules that are targeted to the specific abnormalities of each leukemia subtype. Here, we review abnormalities that are potential therapeutic targets for the treatment of AML in the pediatric population. Full article
(This article belongs to the Special Issue Translational Research on Leukemia)
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