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Insights into Mechanisms Underlying Cardiovascular Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 4325

Special Issue Editors


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Guest Editor
Unit of Brain-Heart Axis, Cellular and Molecular Mechanisms, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy
Interests: cardiovascular diseases; platelet biochemistry; thrombosis; extracellular vesicles; exosomes

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Guest Editor
INSERM U1297, I2MC and Université Paul Sabatier, 31400 Toulouse, France
Interests: cardiovascular diseases; megakaryocytes; platelets; hemostasis; thrombosis; lipids; signaling

Special Issue Information

Dear Colleagues,

Cardiovascular diseases (CVDs) are the leading causes of mortality and morbidity worldwide. Platelet-related thrombotic events, including myocardial infarction and stroke, are among the major targets in the clinical prevention of these cardiovascular diseases. Nevertheless, mechanisms involving platelets as well as endothelial/vascular dysfunctions and inflammation in CVDs appear complex and require continuous efforts to discover new therapeutic targets. This Special Issue on “Insights into Mechanisms Underlying Cardiovascular Disease” will focus on recent advances in molecular and cellular mechanisms involving platelet-related thrombotic events, vascular dysfunctions, and inflammation in CVDs. Answering questions related to this broad topic will provide a substantial gain in the knowledge of these pathologies and will enable clinicians to personalize patient healthcare, which is a major goal for the health system. We are mainly interested in both original and review articles in basic and translational science that describe novel mechanisms involved in, but not limited to, platelet production and activation, thrombo-inflammation and thrombosis, vascular dysfunction, and inflammatory responses in CVDs.

Dr. Marta Zarà
Dr. Sonia Séverin
Guest Editors

Manuscript Submission Information

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Keywords

  • platelets
  • megakaryocytes
  • thrombosis
  • signaling
  • lipids
  • inflammation
  • endothelium
  • cardiovascular diseases

Published Papers (2 papers)

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Review

15 pages, 1438 KiB  
Review
The Contribution of Vascular Proteoglycans to Atherothrombosis: Clinical Implications
by Amelia Drysdale, Amanda J. Unsworth, Stephen J. White and Sarah Jones
Int. J. Mol. Sci. 2023, 24(14), 11854; https://doi.org/10.3390/ijms241411854 - 24 Jul 2023
Cited by 3 | Viewed by 1789
Abstract
The vascular extracellular matrix (ECM) produced by endothelial and smooth muscle cells is composed of collagens and glycoproteins and plays an integral role in regulating the structure and function of the vascular wall. Alteration in the expression of these proteins is associated with [...] Read more.
The vascular extracellular matrix (ECM) produced by endothelial and smooth muscle cells is composed of collagens and glycoproteins and plays an integral role in regulating the structure and function of the vascular wall. Alteration in the expression of these proteins is associated with endothelial dysfunction and has been implicated in the development and progression of atherosclerosis. The ECM composition of atherosclerotic plaques varies depending on plaque phenotype and vulnerability, with distinct differences observed between ruptured and erodes plaques. Moreover, the thrombi on the exposed ECM are diverse in structure and composition, suggesting that the best antithrombotic approach may differ depending on plaque phenotype. This review provides a comprehensive overview of the role of proteoglycans in atherogenesis and thrombosis. It discusses the differential expression of the proteoglycans in different plaque phenotypes and the potential impact on platelet function and thrombosis. Finally, the review highlights the importance of this concept in developing a targeted approach to antithrombotic treatments to improve clinical outcomes in cardiovascular disease. Full article
(This article belongs to the Special Issue Insights into Mechanisms Underlying Cardiovascular Disease)
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22 pages, 2268 KiB  
Review
Pim Kinases: Important Regulators of Cardiovascular Disease
by Sophie Nock, Eima Karim and Amanda J. Unsworth
Int. J. Mol. Sci. 2023, 24(14), 11582; https://doi.org/10.3390/ijms241411582 - 18 Jul 2023
Cited by 2 | Viewed by 2101
Abstract
Pim Kinases; Pim-1, Pim-2, and Pim-3, are a family of constitutively active serine/threonine kinases, widely associated with cell survival, proliferation, and migration. Historically considered to be functionally redundant, independent roles for the individual isoforms have been described. Whilst most established for their role [...] Read more.
Pim Kinases; Pim-1, Pim-2, and Pim-3, are a family of constitutively active serine/threonine kinases, widely associated with cell survival, proliferation, and migration. Historically considered to be functionally redundant, independent roles for the individual isoforms have been described. Whilst most established for their role in cancer progression, there is increasing evidence for wider pathological roles of Pim kinases within the context of cardiovascular disease, including inflammation, thrombosis, and cardiac injury. The Pim kinase isoforms have widespread expression in cardiovascular tissues, including the heart, coronary artery, aorta, and blood, and have been demonstrated to be upregulated in several co-morbidities/risk factors for cardiovascular disease. Pim kinase inhibition may thus be a desirable therapeutic for a multi-targeted approach to treat cardiovascular disease and some of the associated risk factors. In this review, we discuss what is known about Pim kinase expression and activity in cells of the cardiovascular system, identify areas where the role of Pim kinase has yet to be fully explored and characterised and review the suitability of targeting Pim kinase for the prevention and treatment of cardiovascular events in high-risk individuals. Full article
(This article belongs to the Special Issue Insights into Mechanisms Underlying Cardiovascular Disease)
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