Bladder Cancer: Molecular Advances in Pathology, Diagnostics and Therapeutics 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 1381
Special Issue Editor
Special Issue Information
Dear Colleagues,
Bladder cancer ranks among the most frequent malignancies disturbing the wellbeing and health of patients affected. According to the WHO-associated international agency for research on cancer, Cancer Today, approximately 550,000 new cases are diagnosed every year. In regions with a very high human development index the incidence rate is higher, associated with the overall aging of these populations. Occupational and environmental aspects, as well as lifestyle-associated factors, contribute to an individual’s risk of suffering from bladder cancer.
Despite intensive basic and clinical research, the five-year survival rates of bladder cancer patients have not improved significantly in the last twenty to thirty years; however, detailed knowledge of genes and mutants contributing to the initiation of bladder cancer as well as its propagation, data on the expression of cancer-associated cell surface molecules in combination with drugs controlling intracellular pathways, and the better understanding of the role of a distracted immune system in bladder cancer hold great promise for a breakthrough in future cancer therapy.
Progress has also been noted in basic research: the advent of organoid cultures derived from urothelial carcinoma explants has facilitated advanced in vitro studies that investigate cancer etiology and screening for hopeful therapeutics. Modern imaging in combination with deep learning algorithms is improving the power of histology and cancer diagnoses significantly. Future cancer surgery will also be aided by minimally invasive sensors discriminating normal and healthy bladder tissue from mutant and malignant tissue. We therefore look forward to reviews and original articles on different aspects of current methods with which to diagnose and treat urothelial carcinoma in order to improve survival rates.
In this Special Issue of the IJMS on bladder cancer, we will publish papers on the following topics:
- Clinical relevance of the molecular subtyping of bladder cancer;
- Pathology and diagnosis of bladder cancer;
- Evolution of bladder cancer markers on tumor organoids;
- Simplified procedures to generate tumor organoids from urine samples;
- Impedance-based discrimination of bladder cancer.
Other manuscripts will complement the topics listed above.
Prof. Dr. Georgios Gakis
Guest Editor
Manuscript Submission Information
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Keywords
- clinical relevance of molecular subtyping of bladder cancer
- pathology and diagnosis of bladder cancer
- evolution of bladder cancer markers on tumor organoids
- simplified procedures to generate tumor organoids from urine samples
- impedance-based discrimination of bladder cancer
