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Molecular Insights into Platelet Biology and Function

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 533

Special Issue Editors


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Guest Editor
College of Pharmacy and Health Sciences, Campbell University, Buies Creek, NC 27506, USA
Interests: platelets; ether lipids; hemostasis; signaling; thrombosis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Interdisciplinary Oncology, LSU Health Science Center, New Orleans, LA 70112, USA
Interests: coagulation; anticoagulants; platelets; haemostasis; thrombosis; procoagulants; hypoxia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Circulating platelets are highly reactive cell types that respond to a myriad of environmental cues to form homotypic aggregates as well as heterotypic interactions with leukocytes and endothelia. These events not only support a spectrum of normal homeostatic processes such as blood vessel integrity, the initiation of the coagulation cascade, and immunological responses but also ischemic pathologies and coagulopathies.

This Special Issue of the International Journal of Molecular Sciences, entitled “Molecular Insights into Platelet Biology and Function”, will emphasize biological and physiological processes leading to critical platelet functions in hemostasis, coagulopathy, thrombosis and related diseases. The goal is to provide a broad view of platelet reactivity at the molecular level in a variety of physiological contexts. We invite you to contribute original research or focused reviews on the above topics for this Special Issue. We particularly welcome submissions from postdocs, PhD students, and young researchers.

We look forward to reading about your insights and exciting discoveries that further advance our knowledge of this crucial cell type in health and disease.

Dr. Stephen P. Holly
Prof. Dr. Rinku Majumder
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • platelets
  • thrombosis
  • hemostasis
  • reactivity

Published Papers (1 paper)

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Review

17 pages, 1535 KiB  
Review
Pancreatic Cancer and Venous Thromboembolism
by Teagan Prouse, Mohammad A. Mohammad, Sonali Ghosh, Narender Kumar, Ma. Lorena Duhaylungsod, Rinku Majumder and Samarpan Majumder
Int. J. Mol. Sci. 2024, 25(11), 5661; https://doi.org/10.3390/ijms25115661 - 23 May 2024
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Abstract
Pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of all pancreatic cancers and is the most fatal of all cancers. The treatment response from combination chemotherapies is far from satisfactory and surgery remains the mainstay of curative strategies. These challenges warrant identifying [...] Read more.
Pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of all pancreatic cancers and is the most fatal of all cancers. The treatment response from combination chemotherapies is far from satisfactory and surgery remains the mainstay of curative strategies. These challenges warrant identifying effective treatments for combating this deadly cancer. PDAC tumor progression is associated with the robust activation of the coagulation system. Notably, cancer-associated thrombosis (CAT) is a significant risk factor in PDAC. CAT is a concept whereby cancer cells promote thromboembolism, primarily venous thromboembolism (VTE). Of all cancer types, PDAC is associated with the highest risk of developing VTE. Hypoxia in a PDAC tumor microenvironment also elevates thrombotic risk. Direct oral anticoagulants (DOACs) or low-molecular-weight heparin (LMWH) are used only as thromboprophylaxis in PDAC. However, a precision medicine approach is recommended to determine the precise dose and duration of thromboprophylaxis in clinical setting. Full article
(This article belongs to the Special Issue Molecular Insights into Platelet Biology and Function)
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