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Molecular Advances and Insights into Liver Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 361

Special Issue Editor

Department of Correct Anatomy, Medical University of Lublin, 20-090 Lublin, Poland
Interests: fatty liver disease; liver diseases; cholecystectomy; micronutrients; macronutrients
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The increasing incidence rate of various liver diseases is induced by numerous factors and primarily include improper dietary habits, excessive alcohol consumption, the components of the metabolic syndrome such as obesity, or risky behaviors that might result in hepatitis. Although the abovementioned factors are commonly known to be associated with liver dysfunctions, current studies are mostly focused on the molecular mechanisms of liver diseases. Liver diseases might occur due to alcohol consumption, viral infection, or medicine. Further, the occurrence of various hepatic dysfunctions can be a result of genetic (Wilson’s disease, hemochromatosis) or autoimmune (cirrhosis, hepatitis) disorders. The abovementioned conditions could be better understood only by focusing on the pathomechanisms occurring on the molecular level that ultimately induce changes leading to these diseases. A better understanding of such processes will result in improvements in both diagnosis and treatment strategies for the chosen liver diseases.

The major objective of this Special Issue is to provide a space for discussion to clinicians and researchers whose studies are focused on the molecular aspects of the chosen liver diseases. This Special Issue aims to also provide a space for the results of novel studies that were performed to improve the diagnosis of liver diseases and, at the same time, provide novel therapeutic options for patients and expand the knowledge on liver disease pathophysiology. Therefore, we are elated to invite you to submit various types of papers including original papers and narrative and systematic reviews to this Special Issue.

Dr. Jacek Baj
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver
  • hepatocellular carcinoma
  • cancer
  • hepatitis
  • cirrhosis
  • encephalopathy
  • non-alcoholic fatty liver disease
  • autoimmune diseases
  • Wilson’s disease
  • fatty liver disease

Published Papers (1 paper)

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Review

39 pages, 1580 KiB  
Review
Supplementation of Micro- and Macronutrients—A Role of Nutritional Status in Non-Alcoholic Fatty Liver Disease
by Magdalena Tyczyńska, Gabriela Hunek, Martyna Szczasny, Adam Brachet, Jacek Januszewski, Alicja Forma, Piero Portincasa, Jolanta Flieger and Jacek Baj
Int. J. Mol. Sci. 2024, 25(9), 4916; https://doi.org/10.3390/ijms25094916 - 30 Apr 2024
Viewed by 220
Abstract
Non-alcoholic fatty liver disease (NAFLD) is a condition in which the pathological cumulation of fat with coexisting inflammation and damage of hepatic cells leads to progressive dysfunctions of the liver. Except for the commonly well-known major causes of NAFLD such as obesity, dyslipidemia, [...] Read more.
Non-alcoholic fatty liver disease (NAFLD) is a condition in which the pathological cumulation of fat with coexisting inflammation and damage of hepatic cells leads to progressive dysfunctions of the liver. Except for the commonly well-known major causes of NAFLD such as obesity, dyslipidemia, insulin resistance, or diabetes, an unbalanced diet and imbalanced nutritional status should also be taken into consideration. In this narrative review, we summarized the current knowledge regarding the micro- and macronutrient status of patients suffering from NAFLD considering various diets and supplementation of chosen supplements. We aimed to summarize the knowledge indicating which nutritional impairments may be associated with the onset and progression of NAFLD at the same time evaluating the potential therapy targets that could facilitate the healing process. Except for the above-mentioned objectives, one of the most important aspects of this review was to highlight the possible strategies for taking care of NAFLD patients taking into account the challenges and opportunities associated with the micronutrient status of the patients. The current research indicates that a supplementation of chosen vitamins (e.g., vitamin A, B complex, C, or D) as well as chosen elements such as zinc may alleviate the symptoms of NAFLD. However, there is still a lack of sufficient data regarding healthy ranges of dosages; thus, further research is of high importance in this matter. Full article
(This article belongs to the Special Issue Molecular Advances and Insights into Liver Diseases)
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