Hepatocellular Carcinoma in 2023: What Is New on Pathogenesis, Diagnosis and Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 January 2025 | Viewed by 7404
Special Issue Editor
Interests: gut microbiota; liver disease; hepatocellular carcinoma; liver cirrhosis; nonalcoholic fatty liver disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Liver cancer, more specifically hepatocellular carcinoma (HCC), is the second leading cause of cancer-related death, and its incidence is increasing globally. Hepatitis B virus and hepatitis C virus infection are major risk factors for the development of HCC. Nonalcoholic fatty liver disease (NAFLD) is a leading cause of hepatocellular carcinoma (HCC).
The tumor microenvironment (TME) is heterogeneous in patients with HCC and is characterized by complex interactions between immune system cells, tumor cells, and other stromal and resident liver cells. The etiology of liver disease plays a role in controlling the TME and modulating the immune response. Markers of immune suppression in the TME are associated with a poor prognosis in several solid tumors. Immunotherapy with immune checkpoint inhibitors (ICIs) has become the main option for treating cancers, including HCC.
This Special Issue aims to provide a platform for molecular mechanistic research on hepatocellular carcinoma with a special focus on potential treatments and novel pathogenic pathways involved in this disease. We warmly welcome your submissions of original papers and reviews based on results from molecular viewpoints.
Dr. Francesca Romana Ponziani
Guest Editor
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Keywords
- liver cancer
- hepatocellular carcinoma
- hepatitis B virus
- hepatitis C virus
- nonalcoholic fatty liver disease
- HBV
- HCV
- HCC
- NAFLD
- tumor microenvironment
- gut liver axis
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