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Organic Compounds: Structure, Function and Drug Design
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Organic Compounds: Structure, Function and Drug Design

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: closed (29 September 2024) | Viewed by 2374

Special Issue Editor

Dr. Roberta Ettari

E-Mail Website
Guest Editor
Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, University of Messina, Viale Annunziata, 98168 Messina, Italy
Interests: proteasome inhibitors; multiple myeloma therapy; cysteine protease inhibitors; tropical diseases

Special Issue Information

Dear Colleagues,

The development of new drugs is needed to treat different types of diseases related to parasites, virus, bacteria, or fungi and to cure human diseases such as cancer or autoimmune/inflammatory pathologies. In this context, medicinal chemistry can lead to the identification of novel compounds that show pharmacological properties. These novel chemical entities can be chemically synthesized or isolated and purified from natural sources, or they can sometimes be used in combination with a synthetic drug and a nutraceutical.

In this Special Issue, we welcome studies that report on the synthesis/isolation/functionalization/characterization and biological activities of synthetic compounds or of organic compounds obtained from natural sources endowed with biological activity to serve as drug candidates for diseases that impair public health.

Dr. Roberta Ettari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chemical entities
  • nutraceuticals
  • parasite
  • virus
  • bacteria
  • cancer
  • autoimmune diseases
  • inflammatory diseases

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Research

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15 pages, 2166 KiB  
Article
The Senolytic Effect of Indole-3-Carbinol (I3C) on Mouse Embryonic (MEF) and Human Fibroblast Cell Lines
by Scott L. Sax, Maria Laura Centomo, Federica Centofanti, Barbara Rizzacasa, Sierra Cox, Chelsea Cox, Andrea Latini, Maria Rosaria D’Apice, Liliana Mannucci, Giuseppe Novelli and Pier Paolo Pandolfi
Int. J. Mol. Sci. 2024, 25(21), 11652; https://doi.org/10.3390/ijms252111652 - 30 Oct 2024
Viewed by 196
Abstract
Senescence and apoptosis are two fundamental cellular processes that play crucial roles in various physiological and pathological conditions. Senescence refers to the irreversible growth arrest that cells undergo in response to various stimuli, including telomeric alterations, stress, and oncogenic signaling. Pharmacological and/or genetic [...] Read more.
Senescence and apoptosis are two fundamental cellular processes that play crucial roles in various physiological and pathological conditions. Senescence refers to the irreversible growth arrest that cells undergo in response to various stimuli, including telomeric alterations, stress, and oncogenic signaling. Pharmacological and/or genetic removal of senescent cells, also referred to as senolysis, triggers organ rejuvenation and tissue regeneration. Indole-3-carbinol (I3C) is a natural compound contained in Brassicaceae plants and identified in multiple in vitro and in vivo studies as a well-tolerated and effective compound in cancer prevention and therapy. Its anti-cancer properties have been attributed at least in part to its inhibitory activity of proto-oncogenic HECT E3-ubiquitin ligases such as NEDD4 and WWP1. While the tumor suppressive effects of I3C in cancer cell lines have been reported in multiple studies, little is known regarding the biological effects of I3C in primary normal cells, which attain spontaneous cellular senesce over serial passaging. To this end, we used two model systems: mouse embryonic fibroblasts (MEFs) and human primary dermal fibroblasts. Here, we surprisingly show that I3C does increase cellular senescence at early passages, while dramatically reducing the number of senescent cells through the induction of apoptosis in both mouse and human primary cells. Thus, our findings support the notion that I3C acts as a senolytic compound with important therapeutic implications for the prevention and treatment of aging manifestations. The notion can be readily tested in future clinical trials in humans also in view of the high tolerability and safety previously displayed by I3C in preclinical and clinical studies. Full article
(This article belongs to the Special Issue Organic Compounds: Structure, Function and Drug Design)
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Review

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22 pages, 4072 KiB  
Review
The Inhibition of NS2B/NS3 Protease: A New Therapeutic Opportunity to Treat Dengue and Zika Virus Infection
by Josè Starvaggi, Santo Previti, Maria Zappalà and Roberta Ettari
Int. J. Mol. Sci. 2024, 25(8), 4376; https://doi.org/10.3390/ijms25084376 - 16 Apr 2024
Cited by 1 | Viewed by 1954
Abstract
In the global pandemic scenario, dengue and zika viruses (DENV and ZIKV, respectively), both mosquito-borne members of the flaviviridae family, represent a serious health problem, and considering the absence of specific antiviral drugs and available vaccines, there is a dire need to identify [...] Read more.
In the global pandemic scenario, dengue and zika viruses (DENV and ZIKV, respectively), both mosquito-borne members of the flaviviridae family, represent a serious health problem, and considering the absence of specific antiviral drugs and available vaccines, there is a dire need to identify new targets to treat these types of viral infections. Within this drug discovery process, the protease NS2B/NS3 is considered the primary target for the development of novel anti-flavivirus drugs. The NS2B/NS3 is a serine protease that has a dual function both in the viral replication process and in the elusion of the innate immunity. To date, two main classes of NS2B/NS3 of DENV and ZIKV protease inhibitors have been discovered: those that bind to the orthosteric site and those that act at the allosteric site. Therefore, this perspective article aims to discuss the main features of the use of the most potent NS2B/NS3 inhibitors and their impact at the social level. Full article
(This article belongs to the Special Issue Organic Compounds: Structure, Function and Drug Design)
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