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Recent Advances in Skin Diseases
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Recent Advances in Skin Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 May 2024 | Viewed by 6653

Special Issue Editor

Dr. Cosimo Di Raimondo

E-Mail Website
Guest Editor
Department of Dermatology, Università degli Studi di Roma "Tor Vergata", 00133 Rome, Italy
Interests: dermato-oncology

Special Issue Information

Dear Colleagues,

In the last decade, extraordinary progress has been made in the diagnosis and treatment of several skin diseases. New diagnostic techniques, such as dermoscopy or confocal microscopy, along with recent advances in the knowledge related to the pathogenesis of this group of widely heterogeneous disorders, have helped clinicians in the early diagnosis of skin diseases that often have significant histologic and clinical overlap within the defined groups. The importance of differentiating these entities is crucial, as each one has a different clinical course and prognosis.

Furthermore, extraordinary progress has been made in the treatment of chronic inflammatory skin conditions, such as psoriasis and atopic dermatitis, as well as in the oncology field, leading to better management of patients with cutaneous lymphomas, melanoma and non-melanoma skin cancers with a great impact on the overall survival ad quality of life of patients.

This Special Issue intends to bring clinicians up to date with recent advances in the knowledge and management of inflammatory and oncologic skin diseases.

Authors are welcome to contribute their expertise in the field of dermato-oncology and inflammatory diseases, highlighting the recent advances in research, diagnosis and treatment.

Topics to address:

  • New therapies and combinations in cutaneous T and B cell lymphomas;
  • Recent advances in adjuvant and metastatic melanoma therapy;
  • Immunotherapy in the management of non-melanoma skin cancer;
  • Target therapies in melanoma and non-melanoma skin cancers;
  • Update in the pathogenesis of psoriasis and atopic dermatitis;
  • New entities in the treatment of atopic dermatitis;
  • Breaking news in the treatment of alopecia;
  • What is new in the pathogenesis and management of Hidradenitis suppurativa?

Dr. Cosimo Di Raimondo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (4 papers)

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Research

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12 pages, 4006 KiB  
Article
Increased Interleukin-36β Expression Promotes Angiogenesis in Japanese Atopic Dermatitis
by Reo Komaki, Tomomitsu Miyagaki, Miho Tanaka, Kaori Nakajima, Tatsuro Okano, Sora Takeuchi and Takafumi Kadono
Int. J. Mol. Sci. 2023, 24(13), 11104; https://doi.org/10.3390/ijms241311104 - 05 Jul 2023
Cited by 2 | Viewed by 1131
Abstract
While atopic dermatitis (AD) is considered as a T helper 2 (Th2)-centered disease, an increase in other types of inflammatory cytokines is also noted in AD and they may also contribute to the development of the disease. Recently, the efficacy of an anti-IL-36 [...] Read more.
While atopic dermatitis (AD) is considered as a T helper 2 (Th2)-centered disease, an increase in other types of inflammatory cytokines is also noted in AD and they may also contribute to the development of the disease. Recently, the efficacy of an anti-IL-36 receptor antibody in AD was demonstrated in a clinical trial. Although there have been several reports on IL-36α and IL-36γ expression and function in AD, IL-36β has been barely studied. In this report, we examined IL-36β expression and function using clinical samples of AD and the epidermal keratinocyte cell line, HaCaT cells. We demonstrated that IL-36β expression in epidermal keratinocytes was increased in AD lesional skin compared to healthy skin. IL-36β promoted vascular endothelial growth factor A production in HaCaT keratinocytes through phosphorylation of extracellular signal-regulated kinases 1 and 2. In addition, IL-36β up-regulated placental growth factor mRNA expression in HaCaT keratinocytes. IL-36β expression levels in epidermal keratinocytes were correlated with the number of dermal vessels in AD skin. These results suggest that IL-36β may play an important role for angiogenesis in lesional skin of AD and that IL-36β can be a therapeutic target in AD. Full article
(This article belongs to the Special Issue Recent Advances in Skin Diseases)
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Review

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17 pages, 4518 KiB  
Review
Therapeutic Approach in Pigmented Purpuric Dermatoses—A Scoping Review
by Agnieszka Kimak and Agnieszka Żebrowska
Int. J. Mol. Sci. 2024, 25(5), 2644; https://doi.org/10.3390/ijms25052644 - 24 Feb 2024
Viewed by 1036
Abstract
Pigmented purpuric dermatoses (PPD) encompass a group of chronic skin conditions characterized by the presence of petechiae, purpura, and pigmentation changes. While generally benign, these dermatoses can be persistent and aesthetically bothersome. Key clinical features include red to brownish patches with a distinctive [...] Read more.
Pigmented purpuric dermatoses (PPD) encompass a group of chronic skin conditions characterized by the presence of petechiae, purpura, and pigmentation changes. While generally benign, these dermatoses can be persistent and aesthetically bothersome. Key clinical features include red to brownish patches with a distinctive “cayenne pepper” appearance, predominantly localized on the lower extremities, particularly the shins. Subtypes include Schamberg disease, Majocchi’s disease, Gougerot–Blum disease, Ducas and Kapetanakis pigmented purpura, and lichen aureus. Diagnosis relies primarily on clinical evaluation of skin lesions, with biopsy as a confirmatory tool. Although the exact cause of PPD remains unclear, capillary fragility and red blood cell extravasation are implicated. Treatment strategies for PPD aim to alleviate symptoms, considering the generally benign and chronic nature of the condition. As there is no standardized treatment, various methods with varying efficacy are employed. After searching SCOPUS and PubMed databases, we assessed 42 original articles to present current knowledge regarding therapy of PPD. This review will compare treatment approaches specifically in Schamberg disease and other manifestations of pigmented purpuric dermatoses. Full article
(This article belongs to the Special Issue Recent Advances in Skin Diseases)
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14 pages, 1487 KiB  
Review
Are the Cutaneous Microbiota a Guardian of the Skin’s Physical Barrier? The Intricate Relationship between Skin Microbes and Barrier Integrity
by Kornélia Szabó, Beáta Szilvia Bolla, Lilla Erdei, Fanni Balogh and Lajos Kemény
Int. J. Mol. Sci. 2023, 24(21), 15962; https://doi.org/10.3390/ijms242115962 - 04 Nov 2023
Cited by 1 | Viewed by 1716
Abstract
The skin is a tightly regulated, balanced interface that maintains our integrity through a complex barrier comprising physical or mechanical, chemical, microbiological, and immunological components. The skin’s microbiota affect various properties, one of which is the establishment and maintenance of the physical barrier. [...] Read more.
The skin is a tightly regulated, balanced interface that maintains our integrity through a complex barrier comprising physical or mechanical, chemical, microbiological, and immunological components. The skin’s microbiota affect various properties, one of which is the establishment and maintenance of the physical barrier. This is achieved by influencing multiple processes, including keratinocyte differentiation, stratum corneum formation, and regulation of intercellular contacts. In this review, we summarize the potential contribution of Cutibacterium acnes to these events and outline the contribution of bacterially induced barrier defects to the pathogenesis of acne vulgaris. With the combined effects of a Westernized lifestyle, microbial dysbiosis, epithelial barrier defects, and inflammation, the development of acne is very similar to that of several other multifactorial diseases of barrier organs (e.g., inflammatory bowel disease, celiac disease, asthma, atopic dermatitis, and chronic rhinosinusitis). Therefore, the management of acne requires a complex approach, which should be taken into account when designing novel treatments that address not only the inflammatory and microbial components but also the maintenance and strengthening of the cutaneous physical barrier. Full article
(This article belongs to the Special Issue Recent Advances in Skin Diseases)
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15 pages, 335 KiB  
Review
The Diagnosis and Management of Cutaneous Metastases from Melanoma
by Cosimo Di Raimondo, Flavia Lozzi, Pier Paolo Di Domenico, Elena Campione and Luca Bianchi
Int. J. Mol. Sci. 2023, 24(19), 14535; https://doi.org/10.3390/ijms241914535 - 26 Sep 2023
Cited by 3 | Viewed by 1825
Abstract
Melanoma is one of the deadliest skin tumors, accounting for almost 90% of skin cancer mortality. Although immune therapy and targeted therapy have dramatically changed the prognosis of metastatic melanoma, many patients experience disease progression despite the currently available new treatments. Skin metastases [...] Read more.
Melanoma is one of the deadliest skin tumors, accounting for almost 90% of skin cancer mortality. Although immune therapy and targeted therapy have dramatically changed the prognosis of metastatic melanoma, many patients experience disease progression despite the currently available new treatments. Skin metastases from melanoma represent a relatively common event as first sign of advanced disease or a sign of recurrence. Skin metastases are usually asymptomatic, although in advanced stages, they can present with ulceration, bleeding, and superinfection; furthermore, they can cause symptoms related to compression on nearby tissues. Treatments vary from simple surgery resections to topical or intralesional local injections, or a combination of these techniques with the most recent systemic immune or target therapies. New research and studies should focus on the pathogenesis and molecular mechanisms of the cutaneous metastases of melanoma in order to shed light on the mechanisms underlying the different behavior and prognoses of different patients. Full article
(This article belongs to the Special Issue Recent Advances in Skin Diseases)
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