Vaccination against Enterobacteriaceae: From Pre-clinical Models to Translation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: 20 September 2024 | Viewed by 1247
Special Issue Editor
Interests: mucosal immunology; inflammatory bowel disease; lipid biology; cytokines; microbiota; gastrointestinal infections; allelic variations; genetic susceptibility; vaccination
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Some members of the family of Enterobacteriaceae are part of the physiological gut microbiota or transiently colonize the intestine without causing any harm. However, Enterobacteriaceae can also cause severe and even life-threatening infections of multiple organ systems following the acquisition of virulence plasmids or the disruption of commensal microbiota (dysbiosis). Due to the increasing frequency of infections with Enterobacteriaceae in clinical settings and the outbreaks of multi-resistant strains, the use of antibiotics for treatment is increasingly limited. To prevent the spread of multi-drug-resistant Enterobacteriaceae, vaccination next to antibiotic stewardship programs is an alternative promising option. Depending on the species-specific infection sites, the presentation of antigens and the route of immunization need to be carefully considered. Furthermore, the unavailability of suitable animal models for some Enterobacteriaceae hampers preclinical testing and the subsequent design of clinical trials. Thus, novel avenues need to be pursued to characterize the nature of bacterial antigens and to obtain effective vaccine candidates.
Since IJMS is a journal of molecular science, pure clinical studies are not suitable. However, we welcome clinical submissions with biomolecular experiments and encourage authors to reveal new molecular mechanisms in their research.
Prof. Dr. Jochen Mattner
Guest Editor
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Keywords
- enterobacteriaceae
- (mucosal) vaccines
- immunity
- intestinal microbiota
- dysbiosis
- microbial pathogenesis
- animal models
