Pathogenesis and Novel Therapeutic Approaches for Sarcomas

Dear Colleagues,

Malignant bone and soft tissue tumors (sarcomas) are relatively common neoplasms. Some of them are typical of the pediatric age, with all the social, medical, and family stress that this entails. In general, low-grade tumors show a tendency of local recurrence and are often difficult to resect surgically depending on the location. In addition, low-grade sarcomas do not usually show a good response to adjuvant cancer treatments. On the other hand, high-grade sarcomas are very aggressive and have a tendency to metastasize at a distance, and although they show a better response to cancer treatment they usually create resistance to them over time, and the disease ends up progressing. For all of these reasons, it is important to find new therapeutic targets that help us control the spread and progression of the disease. For this, it is important to study the structure, immunophenotype, and molecular alterations of each tumor that help us to better understand the biology of this characteristic group of neoplasms.

Dr. Francisco Giner
Guest Editor

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• soft tissue tumors
• bone tumors
• molecular biology
• target therapies