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Molecular Mechanisms in Cancer Metastasis II

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 10243

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Guest Editor
Faculty of Engineering, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan
Interests: fluorescent imaging; raman spectroscopy; nonlinear microscopy; optical biopsy; cancer metastasis; cancer diagnosis; osteoporosis; cartilage degeneration and regeneration
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Special Issue Information

Dear Colleagues,

Cancer metastasis is the leading cause of death globally. Even if diagnostics in primary cancer is developed, there is an urgent need to understand whether the cancer is localized or has already spread to other organs. The progressive growth of metastases is often resistant to conventional therapies. Understanding the characteristic differences in molecular and cellular biology between primary cancer and metastatic lesions is essential for effective cancer treatment. This Special Issue, “Molecular Mechanisms in Cancer Metastasis”, is a part of the Section ‘’Molecular Pathology, Diagnostics, and Therapeutics’’ in IJMS. Our primary goals of cancer research are technical and instrumental development to address molecular mechanisms in cancer metastasis based on genomics, proteomics, and metabolomics, in vivo and in vitro, and the establishment of a cancer metastasis model in experimental animals and molecular imaging techniques in cancer cells and their environment, including other cells and an extracellular matrix. Metastases can be characterized not only by cancer cells but also by environmental factors, including immune cells, stroma cells, secretion vesicles, and the extracellular matrix, but to identify and detect cancer diagnostic biomarkers is still challenging. The scope of this Special Issue is to approach the pathogenesis in cancer metastasis multilaterally. We welcome full-length original articles and review papers for cancer research in both in vitro and in vivo assay of tumor tissues to reveal the metastasis process and to evaluate the therapeutic effects of anticancer drugs and their drug delivery toward the clinical application of the technique.

Dr. Yusuke Oshima
Guest Editor

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Published Papers (1 paper)

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Review

17 pages, 1125 KiB  
Review
The In Vivo Selection Method in Breast Cancer Metastasis
by Jun Nakayama, Yuxuan Han, Yuka Kuroiwa, Kazushi Azuma, Yusuke Yamamoto and Kentaro Semba
Int. J. Mol. Sci. 2021, 22(4), 1886; https://doi.org/10.3390/ijms22041886 - 14 Feb 2021
Cited by 14 | Viewed by 9875
Abstract
Metastasis is a complex event in cancer progression and causes most deaths from cancer. Repeated transplantation of metastatic cancer cells derived from transplanted murine organs can be used to select the population of highly metastatic cancer cells; this method is called as in [...] Read more.
Metastasis is a complex event in cancer progression and causes most deaths from cancer. Repeated transplantation of metastatic cancer cells derived from transplanted murine organs can be used to select the population of highly metastatic cancer cells; this method is called as in vivo selection. The in vivo selection method and highly metastatic cancer cell lines have contributed to reveal the molecular mechanisms of cancer metastasis. Here, we present an overview of the methodology for the in vivo selection method. Recent comparative analysis of the transplantation methods for metastasis have revealed the divergence of metastasis gene signatures. Even cancer cells that metastasize to the same organ show various metastatic cascades and gene expression patterns by changing the transplantation method for the in vivo selection. These findings suggest that the selection of metastasis models for the study of metastasis gene signatures has the potential to influence research results. The study of novel gene signatures that are identified from novel highly metastatic cell lines and patient-derived xenografts (PDXs) will be helpful for understanding the novel mechanisms of metastasis. Full article
(This article belongs to the Special Issue Molecular Mechanisms in Cancer Metastasis II)
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