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Roles of Cytokines in Lymphocyte Development and Function
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Roles of Cytokines in Lymphocyte Development and Function

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 2591

Special Issue Editor

Prof. Dr. Motonari Kondo

E-Mail Website
Guest Editor
Department of Molecular Immunology, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan
Interests: lymphocyte development; cytokine receptors; signaling; T cell biology

Special Issue Information

Dear Colleagues,

Cytokines play an important role in the process of lymphocyte development by regulating cell growth and inducing lineage-specific gene expression and cell survival. Cytokines are also necessary for proper immune responses by T and B lymphocytes. Due to the advance of technology, our knowledge of molecular mechanisms in the regulation of lymphocyte development and function has been updated. We encourage investigators to submit original or review articles that are concerned with the role of cytokines in lymphocyte development from hematopoietic stem cells, as well as immune response by mature lymphocytes.

Prof. Dr. Motonari Kondo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lymphocyte development
  • immune response
  • T cells
  • B cells
  • cytokines
  • transcription factors
  • cell growth
  • cell survival

Published Papers (1 paper)

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Review

11 pages, 404 KiB  
Review
Flt3 Signaling in B Lymphocyte Development and Humoral Immunity
by Kay L. Medina
Int. J. Mol. Sci. 2022, 23(13), 7289; https://doi.org/10.3390/ijms23137289 - 30 Jun 2022
Cited by 5 | Viewed by 2119
Abstract
The Class III receptor tyrosine kinase Flt3 and its ligand, the Flt3-ligand (FL), play an integral role in regulating the proliferation, differentiation, and survival of multipotent hematopoietic and lymphoid progenitors from which B cell precursors derive in bone marrow (BM). More recently, essential [...] Read more.
The Class III receptor tyrosine kinase Flt3 and its ligand, the Flt3-ligand (FL), play an integral role in regulating the proliferation, differentiation, and survival of multipotent hematopoietic and lymphoid progenitors from which B cell precursors derive in bone marrow (BM). More recently, essential roles for Flt3 signaling in the regulation of peripheral B cell development and affinity maturation have come to light. Experimental findings derived from a multitude of mouse models have reinforced the importance of molecular and cellular regulation of Flt3 and FL in lymphohematopoiesis and adaptive immunity. Here, we provide a comprehensive review of the current state of the knowledge regarding molecular and cellular regulation of Flt3/FL and the roles of Flt3 signaling in hematopoietic stem cell (HSC) activation, lymphoid development, BM B lymphopoiesis, and peripheral B cell development. Cumulatively, the literature has reinforced the importance of Flt3 signaling in B cell development and function. However, it has also identified gaps in the knowledge regarding Flt3-dependent developmental-stage specific gene regulatory circuits essential for steady-state B lymphopoiesis that will be the focus of future studies. Full article
(This article belongs to the Special Issue Roles of Cytokines in Lymphocyte Development and Function)
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