Nano Based Drug Delivery Systems: Future and Development
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 1833
Special Issue Editor
Interests: stimuli-responsive nanoparticles; drug delivery; endosomal escape
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Drugs are a mainstay of modern medicine, but drug development must overcome many hurdles. Nanoparticle technology offers a method to improve therapeutic efficacy by protecting drug cargo and delivering it with high selectivity to a target site. This is particularly important in the field of biological therapeutics including DNA and RNA, which degrade rapidly if delivered in isolation. Although there have been some successes with nanoparticle delivery of biological cargo such as in the recent COVID vaccines, and the siRNA therapy Patisiran, there are still serious issues with efficient delivery of these therapeutics. These include targeting of specific cells, internalization, endosomal escape as well as release of the cargo and intracellular trafficking to site of action. In this Special Issue we will focus on understanding how nanoparticles can be engineered to better migrate these biological barriers and thus provide more efficient delivery systems in the future. Some relevant topics include:
- Stimuli responsive nanoparticles;
- Controlling loading and release of biological cargo;
- Understanding impact of targeting, internalisation, endosomal escape or intracellular trafficking on therapeutic activity;
- New techniques to study nanoparticle/biological interactions.
Dr. Georgina Such
Guest Editor
Manuscript Submission Information
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Keywords
- stimuli-responsive nanoparticles
- endosomal escape
- delivery
- nucleic acid
