The Role of Oxidative Stress Biomarkers in Translational Clinical Research: From the Bench to Bedside
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 9222
Special Issue Editor
Interests: oxidative stress-induced DNA damage and repair and its repair mechanisms in cardiometabolic and cancer diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Biomedical research has spent decades, since the definition of oxidative stress, demonstrating the implications of the alterations in redox metabolism (oxi-reductive stress (ORS) in the physiopathogenesis of multiple diseases and even today the potential of their byproducts as clinical markers has not been successfully validated and thus poorly recognized by clinicians as such. A plethora of different ORS byproducts and selective methodologies are available which enables their assay with enough reproducibility, specificity and sensitivity. Among the oxidative stress markers are many molecules of diverse nature, such as lipid peroxides, oxidized proteins, antioxidants and even the modified bases of DNA and their repair systems, in addition to more recently discovered miRNAs and other related molecules. All of them have potential and should be useful to track different pathologies. However, they have not been commercialized by the pharmaceutical and chemical industry as laboratory tests for their clinical use in the diagnosis and monitoring of diseases. Undoubtedly, the link that remains to be chained in the transition process from the bench to the bedside depends on its evaluation and certification as a sanitary product by the competent institutions and thus, serving as a guide for the manufacturing companies. This space that remains to be covered requires and must go through the contribution of further research and the development of clinical trials with important cohorts that support the robustness of their conclusions.
Scope of the topic: Researchers in the field of experimental biomedicine. Study of oxy-ductive stress (ORS) markers and their validation as emerging clinical markers in cohorts of healthy population and patients with different pathologies.
Prof. Dr. Guillermo T. Sáez
Guest Editor
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Keywords
- DNA and repair systems
- oxidative metabolism
- lipid peroxides
- enzymatic proteins
- DNA damage
