Molecular Basis of Platelet Function in Thrombosis and Beyond
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 4662
Special Issue Editors
Interests: platelets; thrombosis; hemostasis; platelet-neutrophil interactions; bacterial infection; inflammation; valvular heart disease; aortic stenosis; prosthetic heart valves; transcatheter aortic valve implantation; cardiovascular devices
Interests: platelets; metabolism; AMPK signaling; thrombosis; myocardial infarction; ventricular remodeling; fibrosis; cardiac fibroblast biology; endothelial barrier; stent; mouse models; translational research
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Circulating platelets and coagulation play a crucial role in hemostasis, acting to maintain the integrity of a closed circulatory system after blood vessel injury. Under physiological conditions, regulatory mechanisms restrain thrombus formation. When pathologic processes disturb these mechanisms, thrombosis can occur either in the arterial or in the venous circulation with tremendous impact on human health. Thrombosis is the cause of ischemic heart disease, ischemic stroke, and venous thromboembolism, which account for one in four deaths worldwide. Antiplatelet agents have proven efficacy to prevent thrombosis in patients with coronary artery disease or peripheral vascular diseases.
Beyond thrombosis, platelets also contribute to other various biological processes including inflammation, infection, immunity, and cancer. They may also be involved in calcifying or fibrotic diseases. There is therefore a growing interest in assessing whether platelets could be targeted or whether they could represent new biomarkers of initiation, evolution, or outcome in other pathologies than thrombosis.
This Special Issue is dedicated to the identification and description of platelet-related molecular mechanisms underlying not only thrombosis but also other systemic or cardiovascular pathologies, such as acute or chronic inflammatory diseases, cancer, valvular heart diseases, or heart failure. The objective is to highlight potential molecular interventions to prevent or treat theses pathologies towards a molecular medicine perspective.
Dr. Sandrine Horman
Dr. Oury Cécile
Guest Editors
Manuscript Submission Information
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Keywords
- platelets
- thrombosis
- inflammation
- infection
- cancer
- calcification
- fibrosis
- molecular pathology
