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JCDD
Special Issues
Advancements in the Epidemiology, Diagnosis and Treatment of Hypertrophic Cardiomyopathy
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Advancements in the Epidemiology, Diagnosis and Treatment of Hypertrophic Cardiomyopathy

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425).

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1283

Special Issue Editor

Dr. Christos G. Mihos

E-Mail Website
Guest Editor
Division of Cardiology, Mount Sinai Heart Institute, Columbia University Irving Medical Center, Miami Beach, FL 33140, USA
Interests: cardiac imaging; HOCM; hypertrophic cardiomyopathy; ischemic heart disease; strain echocardiography; valvular heart disease

Special Issue Information

Dear Colleagues,

Hypertrophic cardiomyopathy is a heterogeneous clinical disorder with a variable morphologic expression and an increasingly recognized prevalence in the cardiovascular patient community. In the past decade, we have seen exponential growth in the available modalities for patient diagnosis and risk stratification, as well as in treatment options ranging from medical therapy to percutaneous and surgical interventions. The aim of this Special Issue is to highlight this progress from the perspective of international experts across multi-disciplinary modalities via review articles, brief editorials, case reports, or original research. We encourage all interested authors to submit their work and share their experiences of this growing and complex patient population.

Dr. Christos G. Mihos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • alcohol septal ablation
  • CHF
  • heart failure
  • HOCM
  • hypertrophic cardiomyopathy
  • mavacamten
  • mitral valve regurgitation
  • septal myectomy
  • systolic anterior motion

Published Papers (1 paper)

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Research

13 pages, 2947 KiB  
Article
Interventricular Septal Involvement Is Associated with More Impaired Ventricular Function and Mechanics in Apical Hypertrophic Cardiomyopathy
by Christos G. Mihos, Tarec K. Elajami, Deepika Misra, Pranav Venkataraman, Nicholas Gosdenovich and Rafle Fernandez
J. Cardiovasc. Dev. Dis. 2024, 11(3), 74; https://doi.org/10.3390/jcdd11030074 - 21 Feb 2024
Viewed by 1081
Abstract
Background: The interventricular septum has an important role in bi-ventricular performance. We hypothesized that septal involvement in apical hypertrophic cardiomyopathy (ApHCM-Mixed) adversely impacts ventricular structure and function when compared with isolated apical hypertrophy (ApHCM-Pure). Methods: A total of 72 patients (ApHCM-Mixed = 36, [...] Read more.
Background: The interventricular septum has an important role in bi-ventricular performance. We hypothesized that septal involvement in apical hypertrophic cardiomyopathy (ApHCM-Mixed) adversely impacts ventricular structure and function when compared with isolated apical hypertrophy (ApHCM-Pure). Methods: A total of 72 patients (ApHCM-Mixed = 36, ApHCM-Pure = 36) with serial 2D and speckle-tracking echocardiographic analyses were identified. Ventricular function and mechanics were characterized by left (LV) and right (RV) ventricular global longitudinal strain (GLS), RV free wall strain, and LV myocardial work indices, and clinical events were adjudicated. Results: Clinical characteristics were similar between groups (mean age, 66 ± 15 years; 49% female; LV ejection fraction, 68 ± 11%). The ApHCM-Mixed group had larger LV mass indexes (141 ± 39 vs. 111 ± 30 g/m2, p < 0.001), worse LV (−9.6 ± 3.1 vs. −14.4 ± 3.4%, p < 0.001) and RV GLS (−14.3 ± 6.7 vs. −19.2 ± 5.2%, p = 0.001), impaired RV free wall strain (−18.5 ± 7.4 vs. −22.4 ± 6.3%, p = 0.02), and lower LV myocardial work indices including global work index (938 ± 306 vs. 1272 ± 339 mmHg%, p < 0.001), when compared with the ApHCM-Pure group. At a mean follow-up of 3.9 years, these differences all persisted. Five deaths were observed, all occurring in the ApHCM-Mixed group (14% vs. 0, p = 0.05), and with four being cardiac-related. This subgroup had a mean LV ejection fraction of 63%, LV GLS of −8.7%, an LV global work index of 875 mmHg%, and RV free wall strain of −15.9%, indicating significant subclinical bi-ventricular dysfunction. Conclusions: ApHCM-Mixed represents a distinct morphology in hypertrophic cardiomyopathy associated with more impaired ventricular function and mechanics when compared with ApHCM-Pure. Full article
(This article belongs to the Special Issue Advancements in the Epidemiology, Diagnosis and Treatment of Hypertrophic Cardiomyopathy)
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