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Cardiovascular Imaging in Heart Failure with Preserved Ejection Fraction
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Cardiovascular Imaging in Heart Failure with Preserved Ejection Fraction

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Imaging".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 1483

Special Issue Editor

Dr. Daniel A. Morris

E-Mail Website
Guest Editor
Department of Internal Medicine and Cardiology, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
Interests: HFpEF (heart failure with preserved ejection fraction); diastolic dysfunction; echocardiography; speckle-tracking echocardiography; strain; LV strain; LA strain; RV strain; aortic stenosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Currently, the Journal of Cardiovascular Development and Disease (a PubMed-indexed journal) is planning a Special Issue entitled “Cardiovascular Imaging in Heart Failure with Preserved Ejection Fraction”, which will highlight the potential usefulness and clinical relevance of cardiovascular imaging techniques, such as echocardiography and cardiovascular magnetic resonance (CMR), in patients with heart failure with preserved ejection fraction (HFpEF). Specifically, this issue will address the clinical, prognostic, or diagnostic relevance of new imaging parameters, such as left atrial strain, right ventricular strain, left ventricular strain, left ventricular diastolic strain rate, T1 mapping, extracellular volume, or new proposed diagnostic indices or algorithms, in patients with HFpEF.

We are looking forward to receiving your contribution, whether being an original research article, a review article, a meta-analysis article, a systematic-review article, or a clinical trial or study design article.

Yours sincerely,

Dr. Daniel A. Morris
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HFpEF
  • strain imaging
  • cardiovascular magnetic resonance
  • echocardiography

Published Papers (1 paper)

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Research

18 pages, 4666 KiB  
Article
Blood Immune Cell Alterations in Patients with Hypertensive Left Ventricular Hypertrophy and Heart Failure with Preserved Ejection Fraction
by Artem Ovchinnikov, Anastasiya Filatova, Alexandra Potekhina, Tatiana Arefieva, Anna Gvozdeva, Fail Ageev and Evgeny Belyavskiy
J. Cardiovasc. Dev. Dis. 2023, 10(7), 310; https://doi.org/10.3390/jcdd10070310 - 20 Jul 2023
Cited by 2 | Viewed by 1261
Abstract
(1) Background: Chronic inflammation and fibrosis are key players in cardiac remodeling associated with left ventricular hypertrophy (LVH) and heart failure with a preserved ejection fraction (HFpEF). Monocytes and T-helpers (Th) are involved in both pro-inflammatory and fibrotic processes, while regulatory T-cells (Treg) [...] Read more.
(1) Background: Chronic inflammation and fibrosis are key players in cardiac remodeling associated with left ventricular hypertrophy (LVH) and heart failure with a preserved ejection fraction (HFpEF). Monocytes and T-helpers (Th) are involved in both pro-inflammatory and fibrotic processes, while regulatory T-cells (Treg) could be considered to suppress chronic inflammation in the hypertrophied myocardium. We aimed to estimate the relationship between the frequencies of circulating CD4+ T-cell and monocyte subpopulations and the variables of left ventricular (LV) diastolic function in patients with LVH depending on the presence of HFpEF. (2) Methods: We enrolled 57 patients with asymptomatic hypertensive LVH (n = 21), or LVH associated with HFpEF (n = 36). A clinical assessment and echocardiographs were analyzed. CD4+ Treg, activated Th (Th-act), and monocyte (classical, intermediate, and non-classical) subpopulations were evaluated via direct immunofluorescence and flow cytometry. (3) Results: Patients with HFpEF had a lower Treg/Th-act ratio (p = 0.001). Though asymptomatic patients and patients with HFpEF were comparable in terms of both the total monocyte number and monocyte subsets, there were moderate correlations between intermediate monocyte count and conventional and novel echocardiographic variables of LV diastolic dysfunction in patients with HFpEF. (4) Conclusions: In patients with LVH, the clinical deterioration (transition to HFpEF) and progression of LV diastolic dysfunction are probably associated with T-cell disbalance and an increase in intermediate monocyte counts. Full article
(This article belongs to the Special Issue Cardiovascular Imaging in Heart Failure with Preserved Ejection Fraction)
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