Stress, Rhythms Dysregulation and Bipolar Spectrum

Dear Colleagues,

We are delighted to announce a Special Issue of Journal of Clinical Medicine dedicated to exploring recent perspectives on “Stress, Social and Chronobiological Rhythms and Bipolar Spectrum".

Recent evidence suggests that dysregulated social and biological rhythms may significantly contribute to mood disorder development, especially in stressful conditions like the COVID-19 pandemic. Moreover, contemporary socio-economic and cultural factors may both exacerbate bipolar disorder prevalence and lead to paradoxical adaptive conditions in certain cases. The term "Bipolar Spectrum", rooted in the neo-Kraepelinian tradition, encompasses a broad spectrum of mental health conditions beyond traditional bipolar disorder definitions, including depression, mood swings, impulse control disorders, anxiety disorders, personality disorders, substance abuse, and cognitive impairment. This dimensional approach enables us to examine elements across a spectrum, ranging from premorbid functioning systems characterized by traits such as hyperactivity, hyper-energy, and novelty-seeking, to more accurately characterizing prodromal symptoms and the onset of the disorder.

We invite relevant experts and colleagues to share their latest research findings to contribute their scientific and clinical insights on the topic. We encourage submissions of original research, comprehensive reviews, insightful case studies, new treatments and non-pharmacological interventions, and the implementation of strategies for managing medical comorbidities and risk factors. Our aim is to curate a collection of impactful works that hold clinical significance in tailoring care for individuals throughout their lifespan.

Prof. Dr. Mauro Giovanni Carta
Dr. Giulia Cossu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• bipolar spectrum
• neo-Kraepelinian tradition
• dimensional approach
• social rhythms
• chronobiological rhythms