Journal of Clinical Medicine

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Special Issue Editor

Dr. Matteo Zoli

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Guest Editor

Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40121 Bologna, Italy
Interests: skull base surgery; skull base tumors; pituitary tumors; endoscopic endonasal surgery; craniopharyngiomas; chordomas; meningiomas

Special Issue Information

Dear Colleagues,

Skull base tumors and related diseases refer to a group of conditions characterized by the growth of abnormal cells or tissues in the skull base region. These tumors can arise from various structures, including the bones, nerves, blood vessels, and connective tissues of the skull base. Skull base diseases represent a complex and challenging interdisciplinary field, where the modern approach to diagnosis, imaging and therapy involves an interdisciplinary team of neurosurgeons, otorhinolaryngologists, head and neck surgeons, neuroradiologists, and radiation therapy specialists. Currently, significant progress has been made in the diagnosis and treatment of skull base tumors and related diseases. However, the treatment of skull base tumors and related diseases remains challenging due to their location near complex and vital structures. Early diagnosis, personalized treatment, and long-term follow-up are crucial for the prognosis of patients.

This Special Issue welcomes submissions of relevant reviews, literature reviews, perspectives, and clinical research manuscripts.

Dr. Matteo Zoli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

neurosurgery
skull base tumors
minimally invasive approaches
neuro-oncology
endoscopic endonasal surgery

Published Papers (1 paper)

Other

14 pages, 5378 KiB

Open AccessSystematic Review

Clival Metastases: Single-Center Retrospective Case Series and Literature Review

by Alessandro Carretta, Giacomo Sollini, Federica Guaraldi, Arianna Rustici, Marcello Magnani, Sofia Asioli, Marco Faustini-Fustini, Ernesto Pasquini, Matteo Zoli and Diego Mazzatenta

J. Clin. Med. 2024, 13(9), 2580; https://doi.org/10.3390/jcm13092580 - 27 Apr 2024

Viewed by 319

Abstract

Background/Objectives: Clivus metastases from distant neoplasms are uncommon occurrences both in clinical practice and the neurosurgical literature. Surgical management is debated, particularly about the role of surgery and the preferable approach. The aim of this study was to report our surgical experience and review the concerning literature. Methods: Our institutional registry was retrospectively reviewed, and patients who underwent surgical treatment for clival metastasis from 1998 to 2023 were included. A PRISMA systematic review of the literature was performed. Results: Four patients were enrolled, and all of them underwent an endoscopic endonasal approach (EEA). Three presented with cranial nerve (CN) VI palsy. The aim of surgery was biopsy in all cases. No complications were reported. Mean overall survival (OS) was 6 ± 1 months. The systematic review retrieved 27 papers reporting 39 patients who underwent the surgical treatment of clivus metastases. Most of them (79.5%) presented with CN palsies, and EEA was the preferred approach in 92.3% of the cases, to perform a biopsy in most patients (59%). Two hemorrhagic complications (5.1%) were reported, and the mean OS was 9.4 ± 5.6 months. Conclusions: Clival metastases are uncommonly observed, in most cases, during advanced stages of oncological disease. The aim of surgery should be the confirmation of diagnosis and symptomatic relief, balancing the risk–benefit ratio in a multidisciplinary context. EEA is the approach of choice, and it should be carried out in experienced tertiary skull base centers. Full article

(This article belongs to the Special Issue Emerging Treatment Options for Skull Base Tumors and Related Diseases)

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