Clinical Management of Pregnancy-Related Complications—Part II

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 3826

Special Issue Editors


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Guest Editor
1. Breast Department, Rea Maternity Hospital, Pentelis, 175 64 Athens, Greece
2. Medical School, University of Montpellier-Nimes, 34090 Montpellier, France
Interests: high risk pregnancy; gynecology oncology
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Special Issue Information

Dear Colleagues,

Pregnancy is a unique and special period in a woman’s life. It is characterized by the presence of many alterations in the physiological and immune statuses. Several severe pregnancy-related conditions are not frequently seen in women of reproductive age. Often, various clinical specialties act in a multidisciplinary way to confront these complications. This clinical task is a difficult as well as demanding reality and endangers the lives of pregnant women and fetuses. New guidelines based on evidence-based medicine have been produced in order to minimize the frequency of these conditions. In the current Special Issue, we aim to review the pathogenesis and management of these pregnancy-related complications.

Dr. Panagiotis Peitsidis
Dr. Stephanos Zervoudis
Prof. Dr. Panagiotis Tsikouras
Guest Editors

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Keywords

  • diabetes
  • hypertension
  • post-partum hemorrhage
  • preterm labor
  • infection
  • cancer

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Related Special Issue

Published Papers (2 papers)

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Review

13 pages, 1019 KiB  
Review
A Review of the Literature: Amniotic Fluid “Sludge”—Clinical Significance and Perinatal Outcomes
by Sonia-Teodora Luca, Vlăduț Săsăran, Mihai Muntean and Claudiu Mărginean
J. Clin. Med. 2024, 13(17), 5306; https://doi.org/10.3390/jcm13175306 - 7 Sep 2024
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Abstract
Introduction: This paper seeks to report and emphasize the most important aspects from the scientific literature about the diagnostic accuracy of the amniotic fluid “sludge” (AFS), its characterization, its treatment, and its association with premature birth. AFS is defined as a floating freely [...] Read more.
Introduction: This paper seeks to report and emphasize the most important aspects from the scientific literature about the diagnostic accuracy of the amniotic fluid “sludge” (AFS), its characterization, its treatment, and its association with premature birth. AFS is defined as a floating freely hyperechogenic material within the amniotic cavity in the proximity of the internal os. Materials and Methods: We conducted a search on Pubmed and Google Scholar for relevant articles on the subject of amniotic fluid “sludge” published until January 2024. Searches were focused on articles about diagnosis, treatment, maternal and neonatal outcomes, risk of preterm birth, and case reports. The full-text reading stage resulted in the inclusion of 51 studies. Results: AFS is independently associated with chorioamnionitis, preterm delivery, short cervix, increased risk of neonatal morbidity, and cervical insufficiency. This hyperechogenic free-floating material is linked with preterm birth before 32 weeks of gestation, especially when it is associated with short cervical length. Discussion: Present studies identify some controversial benefits of antibiotics in reducing the incidence of preterm birth in women with AFS. Nevertheless, in this review, we can conclude that the presence of AFS in pregnancy is a marker for the microbial invasion of the amniotic cavity, as it is associated with preterm birth. Further studies on a larger group of patients are necessary to clarify and exactly define the terms of managing these cases. Full article
(This article belongs to the Special Issue Clinical Management of Pregnancy-Related Complications—Part II)
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16 pages, 1058 KiB  
Review
The Role of Helicobacter pylori and Metabolic Syndrome-Related Mast Cell Activation Pathologies and Their Potential Impact on Pregnancy and Neonatal Outcomes
by Maria Tzitiridou-Chatzopoulou, Evangelos Kazakos, Eirini Orovou, Paraskevi Eva Andronikidi, Foteini Kyrailidi, Maria C. Mouratidou, Georgios Iatrakis and Jannis Kountouras
J. Clin. Med. 2024, 13(8), 2360; https://doi.org/10.3390/jcm13082360 - 18 Apr 2024
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Abstract
Helicobacter pylori infection, a significant global burden beyond the gastrointestinal tract, has long been implicated in various systemic pathologies. Rising evidence suggests that the bacterium’s intricate relationship with the immune system and its potential to induce chronic inflammation impact diverse pathophysiological processes in [...] Read more.
Helicobacter pylori infection, a significant global burden beyond the gastrointestinal tract, has long been implicated in various systemic pathologies. Rising evidence suggests that the bacterium’s intricate relationship with the immune system and its potential to induce chronic inflammation impact diverse pathophysiological processes in pregnant women that may in turn affect the incidence of several adverse pregnancy and neonate outcomes. Helicobacter pylori infection, which has been linked to metabolic syndrome and other disorders by provoking pericyte dysfunction, hyperhomocysteinemia, galectin-3, atrial fibrillation, gut dysbiosis, and mast cell activation pathologies, may also contribute to adverse pregnancy and neonatal outcomes. Together with increasing our biological understanding of the individual and collective involvement of Helicobacter pylori infection-related metabolic syndrome and concurrent activation of mast cells in maternal, fetus, and neonatal health outcomes, the present narrative review may foster related research endeavors to offer novel therapeutic approaches and informed clinical practice interventions to mitigate relevant risks of this critical topic among pregnant women and their offspring. Full article
(This article belongs to the Special Issue Clinical Management of Pregnancy-Related Complications—Part II)
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