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Special Issues
New Approaches in Fundamental and Clinical Biochemistry
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New Approaches in Fundamental and Clinical Biochemistry

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 4814

Special Issue Editors

Prof. Dr. Mihaela Badea

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Guest Editor
Faculty of Medicine, Research Centre for Fundamental Research and Prevention Strategies in Medicine, Transilvania University of Brasov, B-dul Eroilor nr 29, 500036 Brasov, Romania
Interests: bioanalytical methods; electrochemical (bio) sensors; biochemistry; antioxidants detection; telemedicine; plant food supplements
Special Issues, Collections and Topics in MDPI journals
Dr. Laura Elena Gaman

E-Mail Website
Guest Editor
Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy Medicine, Bucharest, Romania
Interests: the oxidative stress associated with different diseases: mitochondrial disease in children, atherosclerosis and cardiovascular disease, neurological disease like schizophrenia, Alzheimer’s, diabetes, and renal chronic disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Research studies concerning the biomarkers used in clinical diagnosis are very topical and challenging. Selecting, optimizing, and performing diagnostic lab tests permits accurate evaluation of the results and personalized diagnostics.

We intend to involve topics such as signal-transducing pathways, to correlate clinical laboratory diagnosis and therapy in different pathologies. Prevention approaches and the relationship of the biochemical status of subjects with lifestyle will also be considered as topics of particular interest. Naturally-derived bioactive compounds, immunomodulators, inflammation, and not only these proposals will be of interest for articles sent to this Special Issue.

We invite the submission of original manuscripts dealing with the proposed topics, while not being limited to these presented in the frame of the International Conference NT-SMT-LS 2020 (http://www.healthfoodenviron.unitbv.ro/2020/), to be held in Bucharest, Romania. A special discount of 20% will be provided to papers presented during the conference (the authors should add a note in the cover letter "Paper invited by Dr. Mihaela Badea") if the article is accepted by at least two independent reviewers of the journal.

The submission deadline is March 2021. You may send your manuscript at any point from now until the deadline.

We look forward to welcoming your contribution to this Special Issue.

Prof. Dr. Mihaela Badea
Dr. Laura Elena Gaman
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Review

27 pages, 964 KiB  
Review
Effects of Exogenous Androgens on Platelet Activity and Their Thrombogenic Potential in Supraphysiological Administration: A Literature Review
by Adrian Eugen Roşca, Ana-Maria Vlădăreanu, Alina Mititelu, Bogdan Ovidiu Popescu, Corin Badiu, Constantin Căruntu, Suzana Elena Voiculescu, Minodora Onisâi, Şerban Gologan, Radu Mirica and Leon Zăgrean
J. Clin. Med. 2021, 10(1), 147; https://doi.org/10.3390/jcm10010147 - 4 Jan 2021
Cited by 15 | Viewed by 3755
Abstract
Anabolic androgenic steroids (AAS), simply called “androgens”, represent the most widespread drugs used to enhance performance and appearance in a sporting environment. High-dosage and/or long-term AAS administration has been associated frequently with significant alterations in the cardiovascular system, some of these with severe [...] Read more.
Anabolic androgenic steroids (AAS), simply called “androgens”, represent the most widespread drugs used to enhance performance and appearance in a sporting environment. High-dosage and/or long-term AAS administration has been associated frequently with significant alterations in the cardiovascular system, some of these with severe endpoints. The induction of a prothrombotic state is probably the most life-threatening consequence, suggested by numerous case reports in AAS-abusing athletes, and by a considerable number of human and animal studies assessing the influence of exogenous androgens on hemostasis. Despite over fifty years of research, data regarding the thrombogenic potential of exogenous androgens are still scarce. The main reason is the limited possibility of conducting human prospective studies. However, human observational studies conducted in athletes or patients, in vitro human studies, and animal experiments have pointed out that androgens in supraphysiological doses induce enhanced platelet activity and thrombopoiesis, leading to increased platelet aggregation. If this tendency overlaps previously existing coagulation and/or fibrinolysis dysfunctions, it may lead to a thrombotic diathesis, which could explain the multitude of thromboembolic events reported in the AAS-abusing population. The influence of androgen excess on the platelet activity and fluid–coagulant balance remains a subject of debate, urging for supplementary studies in order to clarify the effects on hemostasis, and to provide new compelling evidence for their claimed thrombogenic potential. Full article
(This article belongs to the Special Issue New Approaches in Fundamental and Clinical Biochemistry)
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