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Clinical and Surgical Andrology: Current Challenges and Advances

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A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Reproductive Medicine & Andrology".

Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 6756

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Special Issue Editors

Dr. Marco Capece

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Guest Editor

Department of Urology, University of Naples Federico II, 80138 Naples, Italy
Interests: erectile dysfunction; peyronie’s disease; penile prosthesis; priapism; andrology; urethral strictures; penis; testis cancer; penile cancer

Dr. Marco Falcone

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Guest Editor

Department of Neurourology, Unità Spinale Unipolare, A.O.U. Città della Salute e della Scienza di Torino, 10126 Turin, Italy
Interests: erectile dysfunction; Peyronie’s disease; penile prosthesis; priapism; andrology; urethral strictures

Dr. Andrea Cocci

E-Mail Website
Guest Editor

Department of Urology, Careggi Hospital, University of Florence, 50134 Florence, Italy
Interests: Peyronie’s disease; penile prosthesis; andrology; urethral strictures; testis cancer; penile cancer; premature ejaculation; orgasmic disorders

Special Issue Information

Dear Colleagues,

The field of the male reproductive system, whose pathology and even physiology have been for a long time disregarded or ignored, is gaining increasingly more relevance across the world. Andrology can be defined as a unitary medical and surgical discipline dealing with the pathophysiology of the male reproductive system during the entire life course of the male subject, from development to maturity and senescence. The future of andrological medical and surgical treatments is exciting and, in this Special Issue, entitled “Clinical and Surgical Andrology: Current Challenges and Advances”, we present the latest cutting-edge developments in the fields of male infertility, erectile dysfunction, testis and penile cancer, ejaculation/orgasmic disorders and all the surgeries related to male sexual dysfunction. The aim of this Special Issue is to produce an outstanding updated collection that is able to provide sufficient information to help practitioners with the recent breakthroughs in this field and to guide them in improving and optimizing medical practice.

Dr. Marco Capece
Dr. Marco Falcone
Dr. Andrea Cocci
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

erectile dysfunction
male infertility
male sexual disorders
penile cancer
testis cancer
priapism
hypogonadism

Published Papers (4 papers)

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Research

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10 pages, 666 KiB

Open AccessArticle

Vitamin D, a Regulator of Androgen Levels, Is Not Correlated to PSA Serum Levels in a Cohort of the Middle Italy Region Participating to a Prostate Cancer Screening Campaign

by Felice Crocetto, Biagio Barone, Giulio D’Aguanno, Alfonso Falcone, Rosamaria de Vivo, Monica Rienzo, Laura Recchia and Erika Di Zazzo

J. Clin. Med. 2023, 12(5), 1831; https://doi.org/10.3390/jcm12051831 - 24 Feb 2023

Cited by 5 | Viewed by 1827

Abstract

Prostate cancer (PCa) is the most common non-cutaneous malignancy in men worldwide, and it represents the fifth leading cause of death. It has long been recognized that dietary habits can impact prostate health and improve the benefits of traditional medical care. The activity of novel agents on prostate health is routinely assessed by measuring changes in serum prostate-specific antigen (PSA) levels. Recent studies hypothesized that vitamin D supplementation reduces circulating androgen levels and PSA secretion, inhibits cell growth of the hormone-sensitive PCa cell lines, counteracts neoangiogenesis and improves apoptosis. However, the results are conflicting and inconsistent. Furthermore, the use of vitamin D in PCa treatments has not achieved consistently positive results to date. In order to assess the existence of a correlation between the PSA and 25(OH)vitamin D levels as widely hypothesized in the literature, we analyzed the serum PSA and 25(OH)vitamin D concentration on a cohort of one hundred patients joining a PCa screening campaign. Additionally, we performed medical and pharmacological anamnesis and analyzed lifestyle, as sport practice and eating habits, by administering a questionnaire on family history. Although several studies suggested a protective role of vitamin D in PCa onset prevention and progression, our preliminary results revealed a clear absence of correlation between the serum vitamin D and PSA concentration levels, suggesting that vitamin D has no impact on PCa risk. Further investigations enrolling a huge number of patients are needed with particular attention to vitamin D supplementation, calcium intake, solar radiation that influences vitamin D metabolism and other potential indicators of health to confirm the absence of correlation observed in our study. Full article

(This article belongs to the Special Issue Clinical and Surgical Andrology: Current Challenges and Advances)

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13 pages, 933 KiB

Open AccessArticle

Long-Term Follow-Up after Testicular Torsion: Prospective Evaluation of Endocrine and Exocrine Testicular Function, Fertility, Oxidative Stress and Erectile Function

by Peter Törzsök, Christopher Steiner, Maximilian Pallauf, Michael Abenhardt, Ljiljana Milinovic, Bethseba Plank, Alena Rückl, Manuela Sieberer, Lukas Lusuardi and Susanne Deininger

J. Clin. Med. 2022, 11(21), 6507; https://doi.org/10.3390/jcm11216507 - 2 Nov 2022

Cited by 3 | Viewed by 3316

Abstract

Background: This study investigates endocrine and exocrine testicular function, oxidative stress (OS) in semen, and erectile function in patients who underwent surgery for suspected testicular torsion (TT). Methods: We evaluated 49 patients over a mean follow-up of 101 months: n = 25 patients treated with surgical exploration, n = 20 patients treated with detorsion, and n = 4 treated with orchiectomy. We performed semen analysis including Male infertility Oxidative System (MyOxSIS) analysis, physical examination, and evaluation of endocrine and erectile function. Results: OS, erectile function and spermiogram categories did not differ significantly between the groups. The interval from the onset of symptoms to surgery differed significantly between groups (p < 0.001). Preservation of the testes was associated with a higher round cell count (p = 0.002) and follicle stimulating hormone (FSH, p = 0.003). OS showed a significant positive correlation with the spermiogram category (0.337; p = 0.022). A negative correlation was observed between OS and age (p = 0.033), sperm concentration (p < 0.001) and total sperm count (p = 0.006). Conclusions: Endocrine, exocrine and erectile function are not significantly affected by TT in the long term. Orchiectomy results in elevated FSH and a lower round cell count compared to preservation of the testis. Full article

(This article belongs to the Special Issue Clinical and Surgical Andrology: Current Challenges and Advances)

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10 pages, 456 KiB

Open AccessArticle

COVID-19 Quarantine Dramatically Affected Male Sexual Behavior: Is There a Possibility to Go Back to Normality?

by Lorenzo Spirito, Michele Morelli, Roberto La Rocca, Luigi Napolitano, Claudia Collà Ruvolo, Lorenzo Romano, Angelo di Giovanni, Carmine Sciorio, Sergio Concetti, Emanuele Montanari, Francesca Tripodi, Ferdinando Fusco and Marco Capece

J. Clin. Med. 2022, 11(9), 2645; https://doi.org/10.3390/jcm11092645 - 8 May 2022

Viewed by 1959

Abstract

We performed a monocentric longitudinal study on sexually active male patients, from May 2021 to October 2021, with SARS-CoV-2 infection confirmed with a nasopharyngeal reverse transcriptase polymerase chain reaction (RT-PCR). The questionnaires were delivered by email. The study period was divided into the periods before getting tested (T1), during quarantine (T2), 1 month after a negative test (T3), and 3 months after a negative test (T4). All participants were invited to complete these questionnaires: 10- and 6-item questionnaires, a sexual distress schedule (SDS), and the international index of erectile function questionnaire of 15 items (IIEF-15). The primary endpoint was to evaluate the impact of quarantine on male sexual function (SF) during and after the SARS-CoV-2 infection. A total of 22 male patients met the inclusion criteria. The differences for both SDS and IIEF-15 scores, between T1–T2 (27 (IQR 24.0–32.2) vs. 37.5 (IQR 34.2–45.5), 45 (IQR 38.0–50.2) vs. 28.5 (IQR 19.5–38.0)), T2–T3 (37.5 (IQR 34.2–45.5) vs. 28 (IQR 24.0–31.0), and 28.5 (IQR 19.5–38.0) vs. 39.5 (IQR 35.5–44.2)) were statistically significant (p < 0.001), respectively. Moreover, between T1–T4, no statistically significant difference (p > 0.05) was recorded in both SDS (27 (IQR 24.0–32.2) vs. 26.5 (IQR 24–30.2)) and IIEF-15 (45 (IQR 38.0–50.2) vs. 28.5 (IQR 19.5–38.0)). In 20 patients (90.9%), SARS-CoV-2 had a huge impact on relationship and sexual life, but no patient attended a clinic for sexual difficulties. In conclusion quarantine has negatively influenced SF in infected patients; however, 3 months after the rRT-PCR negative test, a promising return to the preinfection SF values is observed. Full article

(This article belongs to the Special Issue Clinical and Surgical Andrology: Current Challenges and Advances)

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Other

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15 pages, 10399 KiB

Open AccessSystematic Review

Two-Stage Penile Reconstruction after Paraffin Injection: A Case Report and a Systematic Review of the Literature

by Luigi Napolitano, Claudio Marino, Angelo Di Giovanni, Assunta Zimarra, Alessandro Giordano, Carlo D’Alterio, Gianluigi Califano, Massimiliano Creta, Giuseppe Celentano, Roberto La Rocca, Claudia Mirone, Gianluca Spena, Alessandro Palmieri, Nicola Longo, Ciro Imbimbo and Marco Capece

J. Clin. Med. 2023, 12(7), 2604; https://doi.org/10.3390/jcm12072604 - 30 Mar 2023

Cited by 1 | Viewed by 2291

Abstract

Background: Penile injection of foreign materials is an obsolete practice often performed by non-medical personnel in order to enlarge penile size. Methods: A systematic review of the literature from 1956 to 2022 was conducted in accordance with the general guidelines recommended by the Primary Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. We included full papers published from 1956 to 2022. We also described a case report of a 23 year old Bulgarian male affected by penile paraffinoma who underwent a 2-stages surgical technique. Results: A total of 152 cases have been reported, with a median age of 37.9 ranging from 18 to 64 years. Six different techniques have been described in the whole literature: bilateral scrotal flap, simple excision of the paraffinoma with primary closure, two-stage scrotum skin flap, medial prepuce-soprapubic advancement flap technique and penile reconstruction using split thickness skin graft (STSG) or full thickness skin graft (FTSG). An analysis of the distribution among early and late complications was then carried out. Conclusion: In our experience, among the variety of surgical techniques described, a two-stage penile reconstruction using scrotal skin results in excellent cosmetic and functional outcomes, with a low rate of complications. Full article

(This article belongs to the Special Issue Clinical and Surgical Andrology: Current Challenges and Advances)

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