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Biomaterials for Dental Pulp Tissue
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Biomaterials for Dental Pulp Tissue

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Dental Biomaterials".

Deadline for manuscript submissions: closed (20 May 2024) | Viewed by 5261

Special Issue Editors

Dr. Renan Dal Fabbro

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Guest Editor
Department of Cariology, Restorative Sciences and Endodontics, University of Michigan, Ann Arbor, MI, USA
Interests: dental pulp; drug delivery systems; regenerative endodontics; biocompatible materials; tissue scaffolds
Dr. Marco C. Bottino

E-Mail Website
Guest Editor
Department of Cariology, Restorative Sciences and Endodontics, University of Michigan, Ann Arbor, MI, USA
Interests: biomaterials; biofabrication; drug delivery; smart dental biomaterials; 3D printing; tissue engineering
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. João Eduardo Gomes-Filho

E-Mail Website
Guest Editor
Department of Preventive and Restorative Dentistry, Araçatuba School of Dentistry, São Paulo State University - UNESP, Araçatuba, SP, Brazil
Interests: dental pulp; drug delivery systems; regenerative endodontics; biocompatible materials; tissue scaffolds

Special Issue Information

Dear Colleagues,

Dental pulp tissue plays a crucial role in maintaining tooth vitality and overall oral health. However, when this tissue is infected with disease or compromised due to factors such as infection, trauma, or decay, it poses a significant challenge requiring specialized approaches for effective treatment. Overcoming these challenges is essential not only for the well-being of the affected tooth but also for ensuring the patient's oral health and overall quality of life.

Biomaterials have emerged as pivotal tools in revolutionizing the treatment of compromised vital pulp tissue. With the ability to provide a scaffold for tissue regeneration, promote healing, and deliver therapeutic agents, biomaterials offer innovative solutions to address the challenges posed by diseased pulps. Moreover, their adaptability to diverse clinical scenarios, compatibility with the biological environment, and potential for minimizing discomfort and enhancing patient outcomes underscore the profound significance of biomaterials in advancing the field of vital dental pulp tissue treatment. Therefore, the objective of this Special Issue is to publish research on cutting-edge biomaterials tailored for dental pulp tissue applications, with a dual focus on promoting healing responses and fostering tissue regeneration.

Dr. Renan Dal Fabbro
Dr. Marco C. Bottino
Prof. Dr. João Eduardo Gomes-Filho
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dental pulp
  • drug delivery systems
  • regenerative endodontics
  • biocompatible materials
  • tissue scaffolds
 

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Published Papers (2 papers)

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Research

18 pages, 9377 KiB  
Article
Enhancing the Physical, Antimicrobial, and Osteo/Odontogenic Properties of a Sol–Gel-Derived Tricalcium Silicate by Graphene Oxide for Vital Pulp Therapies
by Mohamed Mahmoud Abdalla, Mohammed Zahedul Islam Nizami, Vidhyashree Rajasekar, Mohammed Basabrain, Christie Y. K. Lung and Cynthia Kar Yung Yiu
J. Funct. Biomater. 2024, 15(7), 193; https://doi.org/10.3390/jfb15070193 - 13 Jul 2024
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Abstract
Objectives: This study developed a sol–gel tricalcium silicate/graphene oxide (TCS-GO) composite and examined its physicochemical properties, antimicrobial activity, and osteo/odontogenic effect on dental pulp stem cells. Methods: Tricalcium silicate was synthesized and combined with graphene oxide at three different concentrations, namely 0.02%, 0.04%, [...] Read more.
Objectives: This study developed a sol–gel tricalcium silicate/graphene oxide (TCS-GO) composite and examined its physicochemical properties, antimicrobial activity, and osteo/odontogenic effect on dental pulp stem cells. Methods: Tricalcium silicate was synthesized and combined with graphene oxide at three different concentrations, namely 0.02%, 0.04%, and 0.08% w/w, while tricalcium silicate and mineral trioxide aggregate served as controls. The setting time, compressive strength, pH, and calcium ion release of the composites were evaluated, as well as antimicrobial properties against Streptococcus mutans and Lactobacillus acidophilus. Additionally, the viability of dental pulp stem cells; apatite forming ability; and the gene expression of Alkaline phosphatase, Dentin sialophosphoprotein, and Runt-related transcription factor 2 were assessed. Results: TCS-GO (0.08%) showed a significantly shorter setting time and higher compressive strength when compared to MTA (p < 0.05). Additionally, tricalcium silicate and TCS-GO groups showed a higher release of Ca ions than MTA, with no significant difference in pH values among the different groups. TCS-GO (0.08%) also demonstrated a significantly stronger antimicrobial effect against Lactobacillus acidophilus compared to MTA (p < 0.05). ALP expression was higher in TCS-GO (0.08%) than MTA on days 3 and 7, while DSPP expression was higher in TCS-GO (0.08%) than MTA on day 3 but reversed on day 7. There was no significant difference in RUNX2 expression between TCS-GO (0.08%) and MTA on days 3 and 7. Conclusions: The TCS-GO (0.08%) composite demonstrated superior physicochemical characteristics and antimicrobial properties compared to MTA. Moreover, the early upregulation of ALP and DSPP markers in TCS-GO (0.08%) indicates that it has the potential to promote and enhance the osteo/odontogenic differentiation of DPSCs. Full article
(This article belongs to the Special Issue Biomaterials for Dental Pulp Tissue)
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15 pages, 4307 KiB  
Article
Functionalization of PCL-Based Fiber Scaffolds with Different Sources of Calcium and Phosphate and Odontogenic Potential on Human Dental Pulp Cells
by Caroline Anselmi, Igor Paulino Mendes Soares, Rafaella Lara Maia Mota, Maria Luísa Leite, Rafael Antonio de Oliveira Ribeiro, Lídia de Oliveira Fernandes, Marco C. Bottino, Carlos Alberto de Souza Costa and Josimeri Hebling
J. Funct. Biomater. 2024, 15(4), 97; https://doi.org/10.3390/jfb15040097 - 10 Apr 2024
Cited by 1 | Viewed by 1342
Abstract
This study investigated the incorporation of sources of calcium, phosphate, or both into electrospun scaffolds and evaluated their bioactivity on human dental pulp cells (HDPCs). Additionally, scaffolds incorporated with calcium hydroxide (CH) were characterized for degradation, calcium release, and odontogenic differentiation by HDPCs. [...] Read more.
This study investigated the incorporation of sources of calcium, phosphate, or both into electrospun scaffolds and evaluated their bioactivity on human dental pulp cells (HDPCs). Additionally, scaffolds incorporated with calcium hydroxide (CH) were characterized for degradation, calcium release, and odontogenic differentiation by HDPCs. Polycaprolactone (PCL) was electrospun with or without 0.5% w/v of calcium hydroxide (PCL + CH), nano-hydroxyapatite (PCL + nHA), or β-glycerophosphate (PCL + βGP). SEM/EDS analysis confirmed fibrillar morphology and particle incorporation. HDPCs were cultured on the scaffolds to assess cell viability, adhesion, spreading, and mineralized matrix formation. PCL + CH was also evaluated for gene expression of odontogenic markers (RT-qPCR). Data were submitted to ANOVA and Student’s t-test (α = 5%). Added CH increased fiber diameter and interfibrillar spacing, whereas βGP decreased both. PCL + CH and PCL + nHA improved HDPC viability, adhesion, and proliferation. Mineralization was increased eightfold with PCL + CH. Scaffolds containing CH gradually degraded over six months, with calcium release within the first 140 days. CH incorporation upregulated DSPP and DMP1 expression after 7 and 14 days. In conclusion, CH- and nHA-laden PCL fiber scaffolds were cytocompatible and promoted HDPC adhesion, proliferation, and mineralized matrix deposition. PCL + CH scaffolds exhibit a slow degradation profile, providing sustained calcium release and stimulating HDPCs to upregulate odontogenesis marker genes. Full article
(This article belongs to the Special Issue Biomaterials for Dental Pulp Tissue)
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