Nanoparticles and Biomaterials for Drug Delivery

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Drug Delivery".

Deadline for manuscript submissions: closed (20 February 2024) | Viewed by 2744

Special Issue Editors


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Guest Editor
Department of Pharmacology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
Interests: nanoparticles; biocompatible polymers; chitosan; drug carriers; pain; inflammation; experimental animal models; clinical trials
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Guest Editor
Department of Pharmacology, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Interests: anti-inflammatory drugs; depression; antidepressant drugs; biomarkers; drug delivery systems; in vivo animal models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The advancement of nanomedicine is a medical priority today, with many countries developing new plans to improve research in this field. According to its extensive potential applications in medicine and in medical technologies more widely, the actual directions of nanomedicine advancement are represented by the development of basic science experiments in line with a multidisciplinary vision of nanoscience. Additionally, there is a need for training programs, especially for young researchers, and moreover to provide human resources to private industry.

Nanomedicine offers multiple interesting possibilities of nanotechnology application to significantly improve the development of preventive medicine, medical diagnosis, and therapeutic management.

The applications of nanotechnology in substance delivery systems development have opened up new areas of research in the sustained release of various drugs. Using diverse materials at the nanometer scale, nanotechnology will allow for specific and more personalized diagnosis and treatment of different pathologic areas such as cardiovascular diseases, cancer, inflammatory diseases, neurodegenerative syndromes such as Alzheimer’s or Parkinson’s disease, and psychiatric disturbances. Nanoparticle drug carriers consist of solid biodegradable particles ranging in size from 0.1 to 100 nm in which the active principle is dissolved, entrapped or encapsulated, and/or to which the active principle is absorbed or attached. The important technological advantages of nanoparticles used as drug carriers are high stability, high carrier capacity, a feasibility of incorporation of both hydrophilic and hydrophobic substances, and a feasibility of variable routes of administration. Due to their size, nanoparticles have the advantage of reaching otherwise less accessible sites in the body.

We invite researchers to submit original research articles and review articles. These can focus on a variety of issues, such as the obtention, characterization, structure, and original aspects about biomaterials for drug delivery. These articles will hopefully assist in uncovering novel design technologies, advantages, disadvantages, and their various medical applications.

Prof. Dr. Mititelu Tartau Liliana
Dr. Maria Bogdan
Guest Editors

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Keywords

  • biomaterials
  • biocompatible polymers
  • nanoparticles
  • drug delivery
  • structure–properties relationship
  • biohybrid
  • in vitro study
  • biocompatibility evaluation
  • in vivo animal models
  • various applications of biomaterials

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Published Papers (1 paper)

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Research

16 pages, 7124 KiB  
Article
A pH-Responsive DNA Tetrahedron/Methotrexate Drug Delivery System Used for Rheumatoid Arthritis Treatment
by Yi Jin, Xingyu Ge, Yinjin Xu, Siyi Wang, Qian Lu, Aidong Deng, Jingjing Li and Zhifeng Gu
J. Funct. Biomater. 2023, 14(11), 541; https://doi.org/10.3390/jfb14110541 - 3 Nov 2023
Cited by 1 | Viewed by 2326
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disorder that leads to progressive and aggressive joint inflammation. The disease process is characterized by the activation of macrophages, which then release tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), accelerating tissue damage. Tackling tissue damage is [...] Read more.
Rheumatoid arthritis (RA) is a chronic autoimmune disorder that leads to progressive and aggressive joint inflammation. The disease process is characterized by the activation of macrophages, which then release tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), accelerating tissue damage. Tackling tissue damage is a crucial target in the treatment of RA. In this study, a macrophage-targeted and pH-response DNA tetrahedron/methotrexate drug delivery system was constructed by loading methotrexate (MTX) onto a DNA duplex. MTX was used as a drug model, and a pH-response DNA tetrahedron (TET) was used as the drug carrier, which was modified with hyaluronic acid (HA) to target macrophages. The aim of this study was to evaluate the potential of TET as an effective drug carrier for the treatment of RA. On this basis, we successfully prepared TETs loaded with MTX, and in vitro assays showed that the MTX-TET treatment could successfully target macrophages and induce macrophages to polarize to M1 phenotype. At the same time, we also injected MTX-TET intravenously into collagen-induced arthritis (CIA) model mice, and the redness and swelling of the paws of mice were significantly alleviated, proving that the MTX-TET could successfully target inflamed joints and release MTX to treat joint swelling. In addition, the histochemical results showed that the MTX-TET could reduce synovitis and joint swelling in CIA mice, reduce the level of inflammatory factors in vivo, and improve the disease status while maintaining a good biosafety profile. This study showed that the MTX-TET treatment has beneficial therapeutic effects on RA, providing a new strategy for the clinical treatment of RA. Full article
(This article belongs to the Special Issue Nanoparticles and Biomaterials for Drug Delivery)
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