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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Trends in Microbiology 2025

edited by

Pabulo Rampelotto

and

Milan Kolar

submission deadline 30 Nov 2025 | 15 articles | Viewed by 31068 | Submission Open

Keywords: agricultural microbiology; clinical microbiology; environmental microbiology; food microbiology; industrial microbiology; marine microbiology; microbial biochemistry; microbial biofuel and bioenergy; microbial ecology; microbial evolution; microbial genetics; microbial metabolism; microbial pathogenesis; microbial physiology

(This special issue belongs to the Section Microbiology)

Traumatic Brain Injury (TBI)

edited by

Seyed Ahmad Naseri Alavi

and Andrew J. Kobets

submission deadline 30 Nov 2025 | 5 articles | Viewed by 22593 | Submission Open

Keywords: neurosurgery; neuroscience; Traumatic Brain Injury; TBI; head injury; imaging; prognosis; labaratory findings; quality of life

(This special issue belongs to the Section Medical Research)

Pathophysiology, Diagnosis, and Treatments of Intestinal Diseases

edited by Amosy Ephreim M’Koma

submission deadline 30 Nov 2025 | 5 articles | Viewed by 17392 | Submission Open

Keywords: gastrointestinal disease/disorders; pathophysiology; diagnostics and treatment

(This special issue belongs to the Section Physiology and Pathology)

Plant Functional Genomics and Breeding

edited by

Yifeng Wang

submission deadline 30 Nov 2025 | 7 articles | Viewed by 12952 | Submission Open

Keywords: functional genomics; biological breeding; gene cloning; molecular network; genetic improvement

(This special issue belongs to the Section Plant Science)

Noninvasive Skin Imaging: The Present and the Future in General Dermatology

edited by

Bijan Safai

and

Banu Farabi

submission deadline 30 Nov 2025 | 4 articles | Viewed by 12437 | Submission Open

Keywords: skin imaging; dermatoscopy; dermatology imaging; dermatosurgery; clinical dermatology

(This special issue belongs to the Section Medical Research)

New Insights into Parkinson’s Disease: From Molecular Basis to Therapy

edited by

Kallirhoe Kalinderi

submission deadline 30 Nov 2025 | 5 articles | Viewed by 9515 | Submission Open

Keywords: Parkinson’ s disease; neurodegeneration; genes; GWAs; polygenic risk score; therapy; precision medicine; pathways; pharmacogenetics; surgicogenomics

(This special issue belongs to the Section Medical Research)

Clinical Research in Male Reproduction

edited by Andrea Crafa,

Aldo E. Calogero

and Richard Quinton

submission deadline 30 Nov 2025 | 4 articles | Viewed by 9121 | Submission Open

Keywords: male infertility; male fertility; male sub-fertility; idiopathic male infertility; male reproduction

(This special issue belongs to the Section Medical Research)

Sleep and Sleep Apnea: Impacts, Mechanisms, and Interventions

edited by Yung-An Tsou and Wen-Dien Chang

submission deadline 30 Nov 2025 | 3 articles | Viewed by 6313 | Submission Open

Keywords: obstructive sleep apnea; sleep medicine; sleep surgery; sleep quality; insomnia

(This special issue belongs to the Section Physiology and Pathology)

Synthesis and Evaluation of Novel Anticancer and Anti-Inflammatory Agents

edited by Po-Jen Chen,

Yu-Chia Chang

and Shun-Hua Chen

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5976 | Submission Open

Keywords: anticancer agents; anti-inflammatory agents; pharmacology; molecular and cell biology; drug design; medicinal chemistry; pharmacodynamics; pharmacokinetics; structure– activity relationship (SAR)

(This special issue belongs to the Section Pharmaceutical Science)

Pediatric Ophthalmic Pathology—Integrating Clinical and Basic Research

edited by

Antionette L. Williams

and Brenda L. Bohnsack

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4675 | Submission Open

Keywords: congenital eye anomalies; anterior segment disorders; genetic eye disorders; pediatric eye conditions; pediatric ophthalmology

(This special issue belongs to the Section Physiology and Pathology)

Pharmacokinetic and Pharmacogenetic Approaches in Personalized Medicine

edited by

Silvia De Francia

and Giuliana Abbadessa

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3748 | Submission Open

Keywords: pharmacogenetics; pharmacokinetics; sex; gender; drugs; personalization

(This special issue belongs to the Section Pharmaceutical Science)

Total Joint Arthroplasty and Joint Replacement

edited by

Corrado Ciatti

Luca Andriollo

Francesco Benazzo

and

Stefano Marco Paolo Rossi

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2853 | Submission Open

Keywords: robotic and technology-assisted joint replacement; periprosthetic joint infection— prevention; diagnosis; and therapeutics; biomaterials and implant design; tissue engineering; muscle strengthening and conditioning; implant designs; edema and pain

(This special issue belongs to the Section Medical Research)

Prostate Cancer: 4th Edition

edited by

Paula Oliveira

and

Ana Faustino

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2012 | Submission Open

Keywords: incidence; mortality; diagnosis; histopathology; imaging; treatment; prognosis; case report; animals; humans; modeling

(This special issue belongs to the Section Medical Research)

Gender Medicine: Current Knowledge and Future Perspectives

edited by

Laura Franza

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1910 | Submission Open

Keywords: gender; gender medicine; LGBTQ + health; health equity in gender medicine; intersectionality; pharmacology; reproductive health; chronic diseases; transgender healthcare; sex-specific healthcare

(This special issue belongs to the Section Medical Research)

Advanced Research in Chronic Obstructive Pulmonary Disease: Physiology and Pathology

edited by

I-Shiang Tzeng

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1676 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); biomarkers; inflammation; genomics; microbiome; air pollution

(This special issue belongs to the Section Medical Research)

Prosthetic Joint Infections: A Multidisciplinary Approach

edited by

Andrea Sambri

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1268 | Submission Open

Keywords: orthoplastic approach; prosthetic joint infection; diagnosis and management of PJI; antibiotic therapy in periprosthetic infections

(This special issue belongs to the Section Medical Research)

Novel Therapeutic Strategies for Targeting Glioblastoma Stem Cells

edited by

Tsung-I Hsu

and

Chih Jie Shen

submission deadline 30 Nov 2025 | Viewed by 884 | Submission Open

Keywords: glioblastoma; chemotherapeutic resistance; glioblastoma stem cells; immunosuppression; brain– blood barrier

(This special issue belongs to the Section Physiology and Pathology)

New Horizons: Autoimmune-Related Thrombosis

edited by

Jean Amiral

and

Osamu Kumano

submission deadline 30 Nov 2025 | 1 articles | Viewed by 459 | Submission Open

Keywords: chronic or transient autoantibodies; autoimmune thrombosis; lupus anticoagulant (LA); thrombotic thrombocytopenic Purpura (TTP); anti-phospholipid syndrome (APS); heparin induced thrombocytopenia/and thrombosis (HIT/HITT); vaccine induced thrombotic thrombocytopenia (VITT)

(This special issue belongs to the Section Medical Research)

Environment, Genetics, and Cardiovascular Disease

edited by

Andrea Borghini

submission deadline 30 Nov 2025 | Viewed by 219 | Submission Open

Keywords: cardiovascular disease; environmental exposure; genetics; epigenetics

(This special issue belongs to the Section Medical Research)

Coagulation and Its Disorders: Physiology and Pathological Mechanisms

edited by

Anna Lisa Montemari

submission deadline 30 Nov 2025 | Viewed by 203 | Submission Open

Keywords: coagulation; bleeding disorders; thrombotic mechanisms; animal models; molecular mechanisms; disseminated intravascular coagulation; fibrinolysis; new diagnostic tools and treatment; inflammatory response; thrombin generation; coagulation alterations induced by hepatic and metabolic disorders; drug-induced coagulation alterations

(This special issue belongs to the Section Physiology and Pathology)

Endocrinology and Metabolic Syndrome: Epidemiology

edited by Roman Junik and

Szymon Suwała

submission deadline 30 Nov 2025 | 1 articles | Viewed by 203 | Submission Open

Keywords: metabolic syndrome; obesity; hypertension; diabetes; dyslipidemia; endocrinology

(This special issue belongs to the Section Epidemiology)

Update on Obstructive Sleep Apnea (OSA)

edited by

Konstantinos Chaidas

submission deadline 30 Nov 2025 | Viewed by 199 | Submission Open

Keywords: obstructive sleep apnea; snoring; sleep-disordered breathing; adult sleep apnea; pediatric sleep apnea

(This special issue belongs to the Section Physiology and Pathology)

Pleural and Pulmonary Fibrosis: Pathogenesis and Possible Treatment Strategies

edited by Oluwaseun Adeyanju

submission deadline 30 Nov 2025 | Viewed by 190 | Submission Open

Keywords: pulmonary fibrosis; pleural fibrosis; pathogenesis; therapeutic strategies; inflammation

(This special issue belongs to the Section Physiology and Pathology)

Advances in Millimeter-Wave-Based Pain Therapy

edited by

Jean-Claude Debouzy

and David Crouzier

submission deadline 30 Nov 2025 | Viewed by 172 | Submission Open

Keywords: millimetric waves; pain therapy; pain management; electromagnetic radiations; biophysics

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Etiology, Diagnosis, and Treatment of Coeliac Diseases

edited by Paul J Ciclitira

submission deadline 30 Nov 2025 | Viewed by 129 | Submission Open

Keywords: coeliac disease; blood tests; dietary treatment; etiology

(This special issue belongs to the Section Medical Research)

Investigations of Circular RNAs in Plants

edited by

Srividhya Venkataraman

submission deadline 1 Dec 2025 | 1 articles | Viewed by 1057 | Submission Open

Keywords: plant circRNAs; miRNAs; stress responses; abiotic; biotic; translation; gene regulation; growth; development

(This special issue belongs to the Section Plant Science)

MASLD and Its Comorbidities: From Epidemiology to Future Therapeutic Perspectives

edited by

Simona Cernea

submission deadline 1 Dec 2025 | Viewed by 405 | Submission Open

Keywords: MASLD and comorbidities/complications; diagnostic techniques and biomarkers; clinical trials; innovative therapies

(This special issue belongs to the Section Medical Research)

MASLD and Its Comorbidities: From Pathophysiology Perspectives

edited by

Simona Cernea

submission deadline 1 Dec 2025 | Viewed by 313 | Submission Open

Keywords: MASLD; integrative physiology; pathogenesis; biomarkers; translational research

(This special issue belongs to the Section Physiology and Pathology)

The Role of Stem Cells in Retinal Conditions

edited by

Georgios Panos

, Theo Empeslidis and Lorenzo Motta

submission deadline 10 Dec 2025 | Viewed by 360 | Submission Open

Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Cancer Genomics and Transcriptomics: Uncovering New Frontiers in Tumor Biology

edited by

Panagiotis Adamopoulos

and Panagiotis Tsiakanikas

submission deadline 12 Dec 2025 | Viewed by 335 | Submission Open

Keywords: transcriptomic profiling; tumor heterogeneity; integrative omics; non-coding RNAs; oncogenes

(This special issue belongs to the Section Genetics and Genomics)

Neurological Diseases: Prevention, Diagnostics, Treatment and Rehabilitation

edited by

Constantin Munteanu

and Gelu Onose

submission deadline 15 Dec 2025 | 8 articles | Viewed by 19159 | Submission Open

Keywords: neurological diseases; stroke prevention; stroke treatment; rehabilitation; artificial intelligence; cellular therapy; molecular therapy; interdisciplinary approaches; therapeutic interventions

(This special issue belongs to the Section Medical Research)

Microvascular Dynamics: Insights and Applications

edited by

Aristotle G. Koutsiaris

and Friedrich Jung

submission deadline 15 Dec 2025 | 6 articles | Viewed by 15758 | Submission Open

Keywords: microvessels; dynamics; velocity; flow; rheology; in vitro; animals; humans; biomarkers; imaging; simulations; models; preclinical; clinical

(This special issue belongs to the Section Physiology and Pathology)

Unusual Genomic Traits in Their Evolutionary Context

edited by Miguel Naranjo-Ortiz

submission deadline 15 Dec 2025 | Viewed by 174 | Submission Open

Keywords: unusual genomes; genomic traits; comparative genomics; descriptive genomics; evolutionary genomics; non-model organisms; methodological limitations in genomics

(This special issue belongs to the Section Genetics and Genomics)

2nd Edition—Featured Papers on the Origins of Life

edited by James R. Lyons

submission deadline 17 Dec 2025 | 5 articles | Viewed by 8315 | Submission Open

Keywords: astrobiology; astrochemistry; planetary science; prebiotic chemistry; chirality; chemical evolution; protocells; synthetic biology; complex systems

(This special issue belongs to the Section Origin of Life)

Unravelling the Molecular Mechanisms of Different Stress Responses in Plants

edited by

Hakim Manghwar

submission deadline 18 Dec 2025 | 2 articles | Viewed by 2683 | Submission Open

Keywords: biotic stresses; abiotic stresses; plant growth and development; crop productivity; molecular mechanisms

(This special issue belongs to the Section Plant Science)

Innovative Approaches in Dermatological Therapies and Diagnostics

edited by

Federica Li Pomi

and

Francesco Borgia

submission deadline 26 Dec 2025 | 6 articles | Viewed by 14845 | Submission Open

Keywords: dermatology; inflammatory diseases; skin cancer; non-invasive diagnosis; dermoscopy; confocal dermoscopy; targeted therapy; JAK inhibitors; biologics; artificial intelligence

(This special issue belongs to the Section Medical Research)

Recent Advances in Shockwave Therapy for Musculoskeletal and Soft-Tissue Disorders

edited by

Marco Gesi

Mario Vetrano

, Maria Chiara Vulpiani, Maria Cristina D'Agostino, Larisa Ryskalin and Federica Fulceri

submission deadline 26 Dec 2025 | 5 articles | Viewed by 14263 | Submission Open

Keywords: shockwave; tissue regeneration; pain; functional recovery and healing; physical medicine and rehabilitation; clinical applications; imaging

(This special issue belongs to the Section Medical Research)

Advances in Diagnostic Imaging for Systemic Disorders

edited by Christoph Strolz

submission deadline 29 Dec 2025 | Viewed by 156 | Submission Open

Keywords: high-resolution computed tomography (HRCT); diffusion-weighted imaging (DWI); dual-energy CT in musculoskeletal imaging; high-resolution ultrasonography; SPECT/CT; PET/CT modalities

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Current Views on Knee Osteoarthritis: 3rd Edition

edited by

Sevdalina Nikolova Lambova

submission deadline 30 Dec 2025 | 2 articles | Viewed by 5455 | Submission Open

Keywords: knee osteoarthritis; metabolic syndrome; obesity; pathogenesis; adipokines; disease-modifying; treatment; personalized medicine

(This special issue belongs to the Section Medical Research)

Advances in Dialysis Pathology: Insights into Peritoneal and Hemodialysis Complications

edited by

Chien-Hung Lin

submission deadline 30 Dec 2025 | 1 articles | Viewed by 764 | Submission Open

Keywords: peritoneal dialysis; hemodialysis; acute kidney injury (AKI); chronic kidney disease; pathology; complication

(This special issue belongs to the Section Physiology and Pathology)

Advances in Neural Stem Cell Medicine

edited by Kiminobu Sugaya

submission deadline 30 Dec 2025 | Viewed by 132 | Submission Open

Keywords: neural stem cell; neurodegenerative diseases; cell therapy; exosomes

(This special issue belongs to the Section Physiology and Pathology)

Gastrointestinal Health: Clinical Research and Therapeutic Innovations

edited by

Ludovico Abenavoli

submission deadline 31 Dec 2025 | 21 articles | Viewed by 46373 | Submission Open

Keywords: gut microbiota; inflammatory bowel diseases; irritable bowel syndrome; gastroesophageal reflux disease; fatty liver disease; liver cirrhosis; probiotics; mediterranean diet; epidemiology; diagnosis; treatment; artificial intelligence

(This special issue belongs to the Section Medical Research)

Cystic Fibrosis: A Disease with a New Face

edited by

Janice Wang

and Patricia A. Walker

submission deadline 31 Dec 2025 | 15 articles | Viewed by 45624 | Submission Open

Keywords: cystic fibrosis; CFTR modulator; CF newborn screening; CF nutrition; lung transplant in CF; CF family planning

(This special issue belongs to the Section Medical Research)

Plant Biotic and Abiotic Stresses 2024

edited by

Gastón Pizzio

and

Jie Luo

submission deadline 31 Dec 2025 | 24 articles | Viewed by 37356 | Submission Open

Keywords: plant stress; abiotic stress; biotic stress

(This special issue belongs to the Section Plant Science)

New Trends in Otorhinolaryngology

edited by

Arianna Di Stadio

Massimo Ralli

and

Pietro De Luca

submission deadline 31 Dec 2025 | 9 articles | Viewed by 30900 | Submission Open

Keywords: head and neck; otolaryngology; hearing loss; speech disorders; swallowing disorders; cancer; microRNA; nose; plastic surgery

(This special issue belongs to the Section Medical Research)

Clinical Management and Prevention of Adverse Pregnancy Outcomes

edited by

Zoltan Kozinszky

and

Andrea Suranyi

submission deadline 31 Dec 2025 | 5 articles | Viewed by 23207 | Submission Open

Keywords: pathologic pregnancies; ultrasound; clinical and molecular characteristics; fetal pathologies

(This special issue belongs to the Section Reproductive and Developmental Biology)

New Diagnostic and Therapeutic Developments in Eye and Systemic Diseases

edited by

Zhihong (Jewel) Hu

submission deadline 31 Dec 2025 | 8 articles | Viewed by 21056 | Submission Open

Keywords: eye diseases; systemic diseases; oculomics; ocular imaging; eye surgery; retina; cornea; glaucoma; refractive surgery; OCT; OCTA

(This special issue belongs to the Section Medical Research)

New Insights into Breast Cancer: Current Controversies and Future Perspectives

edited by

Alejandro Martin Sanchez

, Angela Bucaro and Flavia de Lauretis

submission deadline 31 Dec 2025 | 11 articles | Viewed by 17563 | Submission Open

Keywords: breast cancer treatment; oncoplastic surgery; conservative mastectomy; breast reconstruction; sentinel node biopsy; chemotherapy; radiotherapy; integrated therapies

(This special issue belongs to the Section Medical Research)

Advances in Non-Alcoholic Fatty Liver Disease: Pathophysiology, Diagnosis, and Emerging Therapies

edited by

Ioannis Katsaros

and

Dimitrios Schizas

submission deadline 31 Dec 2025 | 4 articles | Viewed by 15837 | Submission Open

Keywords: non-alcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated fatty liver disease (MAFLD); steatohepatitis; metabolic syndrome; insulin resistance; apoptosis/cell death

(This special issue belongs to the Section Medical Research)

Obstetrics and Gynecology Medicine: From Bench to Bedside—2nd Edition

edited by