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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy—Third Edition

edited by

Alin Laurentiu Tatu

submission deadline 18 Aug 2026 | 6 articles | Viewed by 17634 | Submission Open

Keywords: Demodex; endosymbionts; cutaneous microbiome; integrative medicine; optical coherence tomography; dermoscopy; confocal microscopy; cutaneous comorbidities keyword; inflammatory diseases; hair; skin cancer; comorbidities; skin surgery

(This special issue belongs to the Section Physiology and Pathology)

Advances in Geriatric Medicine: Risk Assessment, Biomarkers, and Management Strategies

edited by

Nadya Kagansky

and Yochai Levy

submission deadline 18 Aug 2026 | 3 articles | Viewed by 8303 | Submission Open

Keywords: geriatric risk assessment; biomarkers in aging; personalized geriatric care

(This special issue belongs to the Section Medical Research)

Biomarkers, Neuromodulation and Neuroregulation for Diagnosis and Treatment of Brain Disorders

edited by

Ciprian Ionuț Băcilă

and

Mihnea Costin Manea

submission deadline 18 Aug 2026 | Viewed by 286 | Submission Open

Keywords: neural circuit dysfunction; brain disorders; biomarkers; neuroplasticity; neuromodulation; neuroregulation; multimodal biomarker integration; systems neuroscience approaches

(This special issue belongs to the Section Medical Research)

Challenges and Innovations in Biomaterials for Tissue Engineering

edited by

Fei Fan

, Donny Hanjaya-Putra and Loan Bui

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1536 | Submission Open

Keywords: hydrogels; nanoparticles; extracellular matrix; microfluidics; bio-responsive; tissue engineering; regenerative medicine

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Recent Advances in Head and Neck Disorders

edited by

Cosmin Ioan Faur

and Maximilian Dindelegan

submission deadline 20 Aug 2026 | Viewed by 351 | Submission Open

Keywords: molecular pathology; biomedical technology; systems biology

(This special issue belongs to the Section Medical Research)

Spotlight on Cardiovascular Physiology and Related Diseases: Impact of Sex Differences

edited by

Helena Lenasi

submission deadline 21 Aug 2026 | Viewed by 274 | Submission Open

Keywords: cardiovascular physiology; microcirculation; endothelium; oxidative stress; sex differences; mathematical algorithms for biological signal analysis; metabolic diseases; hyperglycemia

(This special issue belongs to the Section Medical Research)

Advances in Vascular Health and Metabolism—2nd Edition

edited by Ana Blazquez-Medela

submission deadline 26 Aug 2026 | Viewed by 235 | Submission Open

Keywords: cardiovascular; cardiometabolic disease; adipogenesis; atherosclerosis; obesity; overweight; peripheral artery disease

(This special issue belongs to the Section Medical Research)

Nutrition, Metabolism and Fitness: Exploring Dietary Effects on Exercise Physiology

edited by

Jesús Gustavo Ponce González

and

Daniel Velázquez Díaz

submission deadline 27 Aug 2026 | 2 articles | Viewed by 3087 | Submission Open

Keywords: exercise physiology; sports nutrition; metabolic health; diet–exercise interactions; nutritional interventions; energy metabolism; performance and recovery

(This special issue belongs to the Section Physiology and Pathology)

Oral Health and Systemic Conditions: From Biological Insights to Multidimensional Interventions

edited by

Gerson Aparecido Foratori-Junior

Carla Andreotti Damante

and

Nao Taniguchi (Nao Suzuki)

submission deadline 27 Aug 2026 | 1 articles | Viewed by 1081 | Submission Open

Keywords: oral health ; periodontitis ; dental care ; tooth loss ; oral cancer ; facial esthetics ; salivary biomarkers ; systemic–oral health interactions ; non-invasive therapies ; clinical and epidemiological research

(This special issue belongs to the Section Medical Research)

Clinical Manifestations and Treatment of Autoimmune Diseases: 2nd Edition

edited by

Stelvio Tonello

and

Daniele Sola

submission deadline 28 Aug 2026 | 7 articles | Viewed by 16684 | Submission Open

Keywords: autoimmunity; immunobiology; vaccine; leucocytes; immune system

(This special issue belongs to the Section Medical Research)

Gut Health and Nutritional Strategies in Animals

edited by

Jian Ma

and Chunmei Du

submission deadline 28 Aug 2026 | 10 articles | Viewed by 6530 | Submission Open

Keywords: microbiota; barrier function; immunity; precision feeding; additives

(This special issue belongs to the Section Animal Science)

The Age of Longevity: Unpacking Biogerontology and the Future of Human Life

edited by Paweł Kordowitzki

submission deadline 28 Aug 2026 | 1 articles | Viewed by 2033 | Submission Open

Keywords: biogerontology; biological aging; longevity; healthspan extension; cellular senescence; epigenetic reprogramming; senolytics; gene editing; artificial intelligence in aging research

(This special issue belongs to the Section Physiology and Pathology)

Root–Soil–Microbe Interactions: Mechanisms and Management for Plant Performance and Ecosystem Function

edited by

Yuan Li

submission deadline 28 Aug 2026 | 1 articles | Viewed by 1055 | Submission Open

Keywords: Root–soil–microbe interactions; Rhizosphere processes; Plant–microbe networks; Biogeochemical cycling; Microbiome-informed management

(This special issue belongs to the Section Plant Science)

Innovations in Tissue Reconstruction and Wound Repair

edited by Ishith Seth

submission deadline 28 Aug 2026 | 1 articles | Viewed by 953 | Submission Open

Keywords: stem cell therapy; tissue engineering; tissue reconstruction; microsurgery; wound healing; regenerative medicine; biomaterials; perforator flaps; supermicrosurgery

(This special issue belongs to the Section Medical Research)

Omics Approaches in Antipsychotic Pharmacology

edited by

Kyle Burghardt

submission deadline 28 Aug 2026 | Viewed by 406 | Submission Open

Keywords: antipsychotics; genomics; epigenomics; transcriptomics; lipidomics; metabolomics; proteomics; human; animal

(This special issue belongs to the Section Pharmaceutical Science)

Microbial Diversity and Function in Aquatic Environments

edited by Xianglong Chen and

Liang Guo

submission deadline 30 Aug 2026 | 4 articles | Viewed by 10188 | Submission Open

Keywords: aquatic environment; microbial diversity and function; element biogeochemical cycle; interaction between microorganisms and aquatic environments; metaomic approaches

(This special issue belongs to the Section Microbiology)

Skin Diseases and Dermatologic Comorbidities

edited by Alessia Paganelli,

Emanuele Scala

and

Flavia Persechino

submission deadline 30 Aug 2026 | 6 articles | Viewed by 9845 | Submission Open

Keywords: skin diseases; dermatologic comorbidities; metabolic impairment; autoimmunity; cytokines; serum markers

(This special issue belongs to the Section Physiology and Pathology)

Airway Management in Emergency and Intensive Care Medicine

edited by

Prashant Nasa

and Tonny V. Veenith

submission deadline 30 Aug 2026 | 3 articles | Viewed by 9490 | Submission Open

Keywords: airway management; critical care; laryngoscopy; intubation, intratracheal; emergency treatment

(This special issue belongs to the Section Medical Research)

Molecular Muscle Adaptations Across the Lifespan

edited by S. Kyle Travis and

Sime Versic

submission deadline 30 Aug 2026 | 1 articles | Viewed by 5914 | Submission Open

Keywords: muscle tissue; muscle physiology; molecular pathways; therapeutics

(This special issue belongs to the Section Physiology and Pathology)

Advances in Dialysis Pathology: Insights into Peritoneal and Hemodialysis Complications

edited by

Chien-Hung Lin

submission deadline 30 Aug 2026 | 3 articles | Viewed by 3169 | Submission Open

Keywords: peritoneal dialysis; hemodialysis; acute kidney injury (AKI); chronic kidney disease; pathology; complication

(This special issue belongs to the Section Physiology and Pathology)

Global Burden of Chronic Pain: Advances and Challenges in Pain Management and Clinical Practice

edited by Saba Javed and Billy Huh

submission deadline 30 Aug 2026 | 3 articles | Viewed by 2932 | Submission Open

Keywords: chronic pain syndrome; cancer pain syndrome; neuromodulation; intrathecal pump; opioids; nerve blocks; joint injections

(This special issue belongs to the Section Medical Research)

Current Updates on Equidae Breeding and Genetics

edited by

María Dolores Gómez Ortiz

and

Isabel Cervantes

submission deadline 30 Aug 2026 | 2 articles | Viewed by 2708 | Submission Open

Keywords: complex trait; selection; animal welfare; genomic inbreeding; horse; donkey; mule

(This special issue belongs to the Section Animal Science)

Metabolic Eye Diseases: From Tomography to Clinical Prediction

edited by

Akio Oishi

and

Nilufer Yesilirmak

submission deadline 30 Aug 2026 | Viewed by 612 | Submission Open

Keywords: metabolic eye diseases; ophthalmic tomography and imaging biomarkers; diabetic retinopathy and systemic metabolic disorders; mitochondrial dysfunction and optic neuropathies; corneal metabolic diseases and ocular surface disorders; artificial intelligence in clinical prediction of eye diseases; metabolic pathways and retinal degeneration; translational research in metabolic ophthalmology

(This special issue belongs to the Section Physiology and Pathology)

Endocrine Mechanisms and Cellular Dynamics in Obesity: Insights and Innovations

edited by Manuel Gil Lozano and Marina Romaní-Pérez

submission deadline 30 Aug 2026 | Viewed by 507 | Submission Open

Keywords: gastrointestinal peptides; adipokines; food intake regulation; hypothalamus; orexigenic; anorexigenic; adipocytes; pancreatic islets; leptin; insulin

(This special issue belongs to the Section Physiology and Pathology)

Artificial Intelligence and Machine Learning Empower Synthetic and Systems Biology: Theory, Design, Optimization and Application

edited by

Pasquale Stano

and

Jian Xu

submission deadline 30 Aug 2026 | Viewed by 451 | Submission Open

Keywords: AI (artificial intelligence); AI driven drug discovery; automated laboratory platforms; basic and applied science; bioengineering; biological exploration; biological network analysis; complex systems; computational genomics; computational modeling; data driven biology; deep learning; design automation; digital twins in biology; evolutionary design algorithms; gene editing; genetic circuit design; machine learning; metabolic engineering; multi omics integration; predictive biology; protein structure prediction; systems bioinformatics

(This special issue belongs to the Section Synthetic Biology and Systems Biology)

Molecular Mechanisms and Therapeutic Effects of Drugs in Cancer—2nd Edition

edited by

Elżbieta Janina Płuciennik

Żaneta Kałuzińska-Kołat

and

Damian Kołat

submission deadline 31 Aug 2026 | 5 articles | Viewed by 12999 | Submission Open

Keywords: cancer; therapy; cancer drug; molecular mechanism; signaling pathways; targeted therapy; in silico drug response studies; innovative cancer treatment

(This special issue belongs to the Section Medical Research)

Musculoskeletal Function and Exercise Physiology: Integrative Approaches and Emerging Insights

edited by

Robert Smith

Tyler Neltner

Dimitrije Cabarkapa

and Luke Chowning

submission deadline 31 Aug 2026 | 4 articles | Viewed by 7857 | Submission Open

Keywords: resistance exercise; aerobic exercise; sport performance; neuromuscular; electromyography; muscle function; kinematics; kinetics; biomechanics; motion analysis; imaging techniques; muscle biopsy

(This special issue belongs to the Section Medical Research)

Advances in Biomedical Frontier Technologies and Disease Diagnosis

edited by

Alexey Yaremenko

submission deadline 31 Aug 2026 | 2 articles | Viewed by 6738 | Submission Open

Keywords: nanomedicine ; biomaterials ; gene therapy ; drug delivery ; bacteriotherapy ; nanobiotechnology ; hereditary diseases ; bioinformatics ; personalized medicine ; smart biomaterials

(This special issue belongs to the Section Medical Research)

Regulation of Cellular Signaling Pathways in the Metabolic Syndrome

edited by Robert H. Newman and Danielle L. Schmitt

submission deadline 31 Aug 2026 | 4 articles | Viewed by 6144 | Submission Open

Keywords: metabolic syndrome (MetS); cellular signaling pathways; insulin signaling and resistance; nutrient-sensing pathways; inflammation and immune signaling

(This special issue belongs to the Section Physiology and Pathology)

Intensive Care Medicine: Current Concepts and Future Perspectives

edited by Shinichi Watanabe

submission deadline 31 Aug 2026 | 3 articles | Viewed by 5664 | Submission Open

Keywords: intensive care; early mobilization; sepsis; mechanical ventilation; rehabilitation; artificial intelligence; PICS; multidisciplinary collaboration

(This special issue belongs to the Section Medical Research)

Effects of Environmental Factors on Challenges of Plant Breeding: 2nd Edition

edited by

Katalin Magyar-Tábori

and

Nóra Mendler-Drienyovszki

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3827 | Submission Open

Keywords: plant breeding; winter hardiness; sowing time; adaptation to cold/frost; physiology of cold/frost tolerance; snow cover

(This special issue belongs to the Section Plant Science)

Research on Glaucoma Diseases

edited by

Nicoleta Anton

submission deadline 31 Aug 2026 | 2 articles | Viewed by 3618 | Submission Open

Keywords: glaucoma diseases; new technology; artificial intelligence in ophthalmology; gene therapy in glaucoma; new devices; artificial drainage systems

(This special issue belongs to the Section Medical Research)

Conservation Ecology and Management of Mammalian Predators

edited by

Sándor Csányi

and

Miklós Gábor Heltai

submission deadline 31 Aug 2026 | 2 articles | Viewed by 3037 | Submission Open

Keywords: mammalian predators; mesocarnivores; terrestrial predators; predator–prey interactions

(This special issue belongs to the Section Animal Science)

Postharvest Softening, Flavor and Quality of Fruits: Molecular Mechanisms and Regulatory Approaches

edited by Qinggang Zhu and Yaxiu Xu

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1841 | Submission Open

Keywords: fruit softening; fruit quality; fruit flavor; molecular mechanisms; regulatory approaches

(This special issue belongs to the Section Plant Science)

Innovations in Nuclear Medicine and Molecular Imaging

edited by

Christian Kühnel

and

Yiannis Parpottas

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1385 | Submission Open

Keywords: nuclear medicine; molecular imaging; PET; SPECT; radiopharmaceuticals; theranostics; quantitative imaging; artificial intelligence; dosimetry; precision medicine

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Vascular Disease: Etiologic, Diagnostic, Prognostic and Therapeutic Research—3rd Edition

edited by

Dan Mircea Olinic

and

Agata Stanek

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1032 | Submission Open

Keywords: vascular diseases; etiology; diagnosis; prognosis; therapy

(This special issue belongs to the Section Medical Research)

Chronic Kidney Diseases: Epidemiology, Diagnosis, and Treatment

edited by

Stefanos Roumeliotis

submission deadline 31 Aug 2026 | 2 articles | Viewed by 862 | Submission Open

Keywords: chronic kidney disease; end stage kidney disease; hemodialysis; peritoneal dialysis; mitochondria; oxidative stress; vascular calcification

(This special issue belongs to the Section Medical Research)

Management of Inflammatory Airway Diseases

edited by

Diego Bagnasco

and

Benedetta Bondi

submission deadline 31 Aug 2026 | 1 articles | Viewed by 672 | Submission Open

Keywords: inflammatory airway diseases; asthma; EGPA; COPD; chronic rhinosinusitis; biomarkers; biologics; treatable traits; precision medicine

(This special issue belongs to the Section Medical Research)

Research Advances in Wetland Ecology

edited by

Yuxiang Yuan

and

Yunlong Yao

submission deadline 31 Aug 2026 | Viewed by 372 | Submission Open

Keywords: wetland; restoration; function; plant; algae; lake eutrophication; interspecific relationship; biogeochemical cycling; climate change

(This special issue belongs to the Section Biodiversity, Ecology and Evolution)

Cellular and Molecular Biology Behind Human Cognition

edited by

Simone Battaglia

and Masaru Tanaka

submission deadline 31 Aug 2026 | Viewed by 343 | Submission Open

Keywords: cognitive biology; synaptic and cellular plasticity; non-invasive brain stimulation techniques; synaptic and circuit plasticity; cognitive resilience; biomarkers of cognitive function; neuroinflammation and neurodegeneration; translational neuroscience; neuroplasticity; precision medicine: biomarkers, neurochemical

(This special issue belongs to the Section Physiology and Pathology)

Protein Structure and Engineering: From Folding Cages to Functional Assemblies

edited by

Delia Picone

Giarita Ferraro

and

Rosanna Lucignano

submission deadline 31 Aug 2026 | Viewed by 331 | Submission Open

Keywords: protein structure; self-assembly; functional assemblies; protein engineering; protein–protein interaction; biomaterials; building blocks; biotechnological applications

(This special issue belongs to the Section Genomics and Proteomics)

Molecular Regulation of Fruit Development in Solanaceous Crops: From Genes to Phenotypes

edited by

Han Xiao

, Wencai Yang and Ruohe Yin

submission deadline 31 Aug 2026 | Viewed by 307 | Submission Open

Keywords: Solanaceous crops; fruit development; omics; genetics; phenotype

(This special issue belongs to the Section Plant Science)

Progress in Rehabilitation Interventions for Heart Failure

edited by

João Morais

, Jhonatan Betancourt-Peña, Iago Portela and Mauricio Hernández-Carrillo

submission deadline 31 Aug 2026 | Viewed by 290 | Submission Open

Keywords: heart failure; rehabilitation; exercise; interdisciplinary; telerehabilitation

(This special issue belongs to the Section Medical Research)

The Biochemistry of Venoms: Exploring Molecular Diversity, Structural Mechanisms, and Their Biotechnological Uses

edited by

Malson Neilson Lucena

and Ludovico Migliolo

submission deadline 31 Aug 2026 | Viewed by 285 | Submission Open

Keywords: biochemistry of venoms; venomics; diversity of toxins; mechanism of action; bioprospecting

(This special issue belongs to the Section Pharmaceutical Science)

Innovations in the Diagnosis and Treatment of Inflammatory Bowel Disease

edited by Aldona Wierzbicka-Rucinska

submission deadline 31 Aug 2026 | Viewed by 279 | Submission Open

Keywords: inflammatory bowel disease (IBD); molecular and imaging diagnostics; personalized treatment approaches; precision medicine; pharmacological and biologic therapies; pathophysiology

(This special issue belongs to the Section Medical Research)

Molecular Pathways Shaping Head and Neck Cancer Care

edited by

Albert Yoon-Kyu Han

submission deadline 31 Aug 2026 | Viewed by 275 | Submission Open

Keywords: head and neck cancer; molecular pathways; tumor microenvironment; precision oncology; translational research

(This special issue belongs to the Section Medical Research)

A Paradigm Shift in Airway and Pain Management—3rd Edition

edited by

Jui An Lin

submission deadline 31 Aug 2026 | Viewed by 272 | Submission Open

Keywords: airway management; difficult airway; video intubating stylet; pain management; ultrasonography; motor-sparing strategies; nerve block; regenerative medicine; transarterial embolization for pain management; joint denervation for pain management; rTMS (repetitive transcranial magnetic stimulation); central post-stroke pain; neuromodulation

(This special issue belongs to the Section Medical Research)

Diagnosis, Treatment and Prognosis of Head and Neck Disorders

edited by

Geng-He Chang

submission deadline 31 Aug 2026 | 1 articles | Viewed by 271 | Submission Open

Keywords: head and neck disorders ; head and neck cancer ; otolaryngology ; diagnostic imaging and endoscopy ; targeted therapy and immunotherapy ; biomarkers and molecular pathology ; precision medicine ; prognostic models and outcomes ; translational research

(This special issue belongs to the Section Medical Research)

Myeloproliferative Neoplasms: From Biology to Practice

edited by Adrian Duek

submission deadline 31 Aug 2026 | Viewed by 262 | Submission Open

Keywords: polycythemia vera; essential thrombocythemia; primary myelofibrosis; JAK2 V617F; calreticulin; MPL; next-generation sequencing; risk factor scores

(This special issue belongs to the Section Medical Research)

Nutritional Value and Stress Tolerance Mechanisms in Legume Crops

edited by Carlos Pimentel

submission deadline 31 Aug 2026 | Viewed by 226 | Submission Open

Keywords: water stress; temperature; salinity; heavy metals; stress adaptation; biological nitrogen fixation; grain quality; yield

(This special issue belongs to the Section Plant Science)

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