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Life
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Novel Therapeutics for Male Infertility
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Novel Therapeutics for Male Infertility

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 4691

Special Issue Editors

Dr. Filippo Giacone

E-Mail Website
Guest Editor
Centro HERA - Unità di Medicina della Riproduzione, Via Barriera del Bosco 51/53, Sant'Agata li Battiati, 95030 Catania, Italy
Interests: male infertility; reproductive biology; semen analysis; sperm DNA fragmentation
Dr. Sandrine Chamayou

E-Mail Website
Guest Editor
Centro HERA - Unità di Medicina della Riproduzione, Via Barriera del Bosco 51/53, Sant'Agata li Battiati, 95030 Catania, Italy
Interests: male infertility; reproductive genetic; embryology; preimplantation genetic testing
Dr. Rossella Cannarella

E-Mail Website
Guest Editor
1. Glickman Urological & Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
2. Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy
Interests: male infertility; reproductive endocrinology; general endocrinology; andrology; sexual health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is clear that 30-35% of couple infertility is due to a male factor. In 5-20% of these cases, male infertility results from idiopathic etiology. Factors such as a lack of andrological follow-up and, thus, prevention during the male’s life, advanced paternal age at the moment of desired fatherhood, and the accumulation of harmful molecules such as endocrinal disrupting chemicals (EDCs) from our living environment contribute to the inevitable worsening of semen quality. Consequently, the number of couples requiring assisted reproductive technology is constantly increasing. In this context, andrology, as a relatively young discipline, could provide answers by developing new therapies for improved semen quality.

Nowadays, available medical therapies are based on hormone administration and the prescription of antioxidants and supplements. The aim of this andrology issue is to collect studies that report innovative diagnostic or therapeutic approaches to understand the causes and solve male infertility. For all these reasons, we are pleased to invite you and your colleagues to contribute original research articles, reviews, systematic reviews, meta-analyses, or case reports to this Special Issue. As an expert in male infertility, your support is crucial for improving the diffusion of scientific knowledge and commitment to resolving male infertility.

Dr. Filippo Giacone
Dr. Sandrine Chamayou
Dr. Rossella Cannarella
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • male infertility
  • andrology
  • novel therapeutics
  • sexual health
  • semen

Published Papers (2 papers)

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Research

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11 pages, 825 KiB  
Article
The Association between Abstinence Period and Semen Parameters in Humans: Results in Normal Samples and Different Sperm Pathology
by Min Xie, Silvan Hämmerli and Brigitte Leeners
Life 2024, 14(2), 188; https://doi.org/10.3390/life14020188 - 27 Jan 2024
Viewed by 2002
Abstract
Background: The impact of sexual abstinence on sperm quality, particularly in pathological cases, is a subject of debate. We investigated the link between abstinence duration and semen quality in both normal and pathological samples. Methods: We analyzed semen samples from 4423 men undergoing [...] Read more.
Background: The impact of sexual abstinence on sperm quality, particularly in pathological cases, is a subject of debate. We investigated the link between abstinence duration and semen quality in both normal and pathological samples. Methods: We analyzed semen samples from 4423 men undergoing fertility evaluation, comprising 1256 samples from healthy individuals and 3167 from those with conditions such as oligozoospermia, asthenozoospermia, teratozoospermia, or a combination of these factors, namely oligoasthenoteratozoospermia (OAT). Parameters including sperm concentration, the percentage of progressively motile spermatozoa, total motile sperm count, and the percentage of spermatozoa with normal morphology were assessed at various abstinence durations (each day, 0–2, 3–7, and >7 days). Results: Extended abstinence correlated with higher sperm concentration overall (p < 0.001), except in oligozoospermia. Longer abstinence reduced progressive motility in normal (p < 0.001) and teratozoospermic samples (p < 0.001). Shorter abstinence was linked to higher morphologically normal sperm in normal samples (p = 0.03), while longer abstinence did so in oligoasthenoteratozoospermic samples (p = 0.013). Conclusion: The findings suggest that a prolonged abstinence time is linked to higher sperm concentration, while optimal sperm motility is observed after shorter abstinence periods. However, results regarding morphology remain inconclusive. Recommendations on abstinence duration should be tailored based on the specific parameter requiring the most significant improvement. Full article
(This article belongs to the Special Issue Novel Therapeutics for Male Infertility)
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Review

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16 pages, 323 KiB  
Review
Chronic Prostatitis/Chronic Pain Pelvic Syndrome and Male Infertility
by Andrea Graziani, Giuseppe Grande, Michel Martin, Giordana Ferraioli, Elena Colonnello, Massimo Iafrate, Fabrizio Dal Moro and Alberto Ferlin
Life 2023, 13(8), 1700; https://doi.org/10.3390/life13081700 - 7 Aug 2023
Cited by 1 | Viewed by 2173
Abstract
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is defined as urologic pain or discomfort in the pelvic region, associated with urinary symptoms and/or sexual dysfunction, lasting for at least 3 of the previous 6 months. The rate of symptoms related to prostatitis has a [...] Read more.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is defined as urologic pain or discomfort in the pelvic region, associated with urinary symptoms and/or sexual dysfunction, lasting for at least 3 of the previous 6 months. The rate of symptoms related to prostatitis has a mean prevalence of 8–8.2%. CP/CPPS is most frequent in men younger than 50 years, among whom it is the most common urologic diagnosis. In the last decades, many studies have been published on CP/CPPS and its association with male infertility. The pathophysiologic relation between CP/CPPS and male infertility involves several aspects, which are not well studied yet. A reduction in semen parameters has been demonstrated in patients with CP/CPPS, and several mechanisms have been proposed to represent putative pathophysiological links between CP/CPPS and infertility, including male accessory gland inflammation, metabolic syndrome, inflammatory bowel disease, HPV co-infection and autoimmunity. In light of this evidence, a multidisciplinary approach is advocated for patients with known CP/CPPS, and particular attention is needed for male patients of infertile couples in order to evaluate male accessory glands correctly. In addition, it is advisable that future studies dealing with the treatment of CP/CPPS take into consideration all the different pathophysiological aspects implicated. Full article
(This article belongs to the Special Issue Novel Therapeutics for Male Infertility)
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