Development of Anticancer and Antiviral Drugs—2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Pharmaceutical Science".

Deadline for manuscript submissions: closed (17 February 2024) | Viewed by 2289

Special Issue Editors


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Guest Editor
Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan
Interests: DNA-binding drug design; anticancer drug targeting DNA or RNA; coronavirus nucleocapsid protein; antiviral drug development; structural biology; virology; X-ray crystallography; biophysical techniques
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan
Interests: nucleic acids structures and functions; DNA mismatches; DNA-binding drugs; anticancer drug development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The editors are grateful to the many researchers who contributed to the success of the first volume of this issue (https://www.mdpi.com/journal/life/special_issues/Anticancer_and_Antiviral_Drugs). Therefore, we are very pleased to announce the second volume of our Special Issue "Development of Anticancer and Antiviral Drugs—2nd Edition".

Technological advances in recent years have enabled significant progress in the development of drugs for various diseases. However, cancer and viral diseases remain the two major categories of human diseases that require special attention in drug development. Many drugs have been approved for clinical use to treat cancers and viral infections, but none of these drugs are without toxicities or other side effects. In addition, the heterogeneity of cancers and drug resistance pose another problem for currently available drugs. Therefore, the continuous search for new candidates that can be used against cancer and viral diseases is necessary. In drug discovery, initial laboratory studies, such as the identification of novel druggable targets or potential lead molecules; screening; and evaluation of druggable properties of small molecule compounds, etc., play an important role. The advent of new molecular and cell biology techniques, bioinformatics, genomics, and other structural and functional methods have made possible new opportunities for anticancer and antiviral drug development. With this Special Issue, we aim to provide an overview of recent advances in cancer and antiviral drug development to a broader academic and scientific community.

We invite you to contribute original research articles, reviews, clinical study results, molecular and bioinformatics analyses, and structural and biophysical studies on anticancer and antiviral drug development that highlight new advances in the field.

We look forward to receiving your submission.

Prof. Dr. Ming-Hon Hou
Dr. Roshan Satange
Guest Editors

Manuscript Submission Information

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Keywords

  • cancers
  • viral diseases
  • drug development
  • anticancer drugs
  • antiviral drugs
  • drug discovery
  • structure-based drug designing
  • molecular biology
  • cell biology

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Published Papers (1 paper)

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Review

17 pages, 919 KiB  
Review
Applied Cardio-Oncology in Hematological Malignancies: A Narrative Review
by Evdokia Mandala, Kyranna Lafara, Dimitrios Kokkinovasilis, Ioannis Kalafatis, Vasiliki Koukoulitsa, Eirini Katodritou and Christos Lafaras
Life 2024, 14(4), 524; https://doi.org/10.3390/life14040524 - 18 Apr 2024
Cited by 1 | Viewed by 2014
Abstract
Applied cardio-oncology in hematological malignancies refers to the integration of cardiovascular care and management for patients with blood cancer, particularly leukemia, lymphoma, and multiple myeloma. Hematological cancer therapy-related cardiotoxicity deals with the most common cardiovascular complications of conventional chemotherapy, targeted therapy, immunotherapy, chimeric [...] Read more.
Applied cardio-oncology in hematological malignancies refers to the integration of cardiovascular care and management for patients with blood cancer, particularly leukemia, lymphoma, and multiple myeloma. Hematological cancer therapy-related cardiotoxicity deals with the most common cardiovascular complications of conventional chemotherapy, targeted therapy, immunotherapy, chimeric antigen receptor T (CAR-T) cell and tumor-infiltrating lymphocyte therapies, bispecific antibodies, and hematopoietic stem cell transplantation. This narrative review focuses on hematological cancer-therapy-related cardiotoxicity’s definition, risk stratification, multimodality imaging, and use of cardiac biomarkers to detect clinical and/or subclinical myocardial dysfunction and electrical instability. Moreover, the most common cardiotoxic profiles of the main drugs and/or therapeutic interventions in patients with hematological malignancies are described thoroughly. Full article
(This article belongs to the Special Issue Development of Anticancer and Antiviral Drugs—2nd Edition)
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