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Life
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Mechanical Circulatory Support in Circulatory Failure: The State of the...
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Mechanical Circulatory Support in Circulatory Failure: The State of the Art

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 20 May 2024 | Viewed by 589

Special Issue Editors

Dr. Raphaël Giraud

E-Mail Website
Guest Editor
1. Intensive Care Unit, Geneva University Hospitals, CH-1205 Geneva, Switzerland
2. Geneva Hemodynamic Research Group, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland
3. Surgical Intensive Care Division, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland
Interests: anaesthetics; critical care medicine; hemodynamics; cardiac output; transesophageal echocardiography; echocardiography; mechanical ventilation; intensive care medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Benjamin Assouline

E-Mail Website
Guest Editor
1. Division of Intensive Care, Department of Acute Medicine, Geneva University Hospitals, Geneva, Switzerland
2. Geneva Hemodynamic Research Group, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland
3. Faculty of Medicine, University of Geneva, Geneva, Switzerland
Interests: cardiogenic shock; acute respiratory distress syndrome; extracorporeal life support; mechanical circulatory support
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the last decade, temporary mechanical circulatory support (tMCS) has progressively become crucial to the management of critically ill patients presenting refractory circulatory failure.

Percutaneous devices are now widely employed as a bridge to recovery, long-term MCS, organ transplant or decision. The applications of temporary MCS are no longer restricted to patients presenting acute myocardial-infarction-associated cardiogenic shock (AMI-CS) or post-cardiotomy syndrome. Indeed, emerging applications have increased significantly in recent years, including, notably, septic cardiomyopathy, massive pulmonary embolism, obstetric catastrophes (embolic or cardiogenic), bridge to liver, lung and cardiac transplant and ECPR.

In addition to VA-ECMO, which is considered the gold-standard of extracorporeal life support in modern cardiac critical care, other devices (IMPELLA, the Protek-DUO and TandemHeart) are now available and increasingly employed.

While the evidence supporting MCS in numerous contexts remains scarce, several trials have recently been published on this topic. The aim of this Special Issue is to provide an update on the state of the art regarding the utilization and management of temporary MCS in refractory circulatory failure, beyond its usual applications in AMICS and post-cardiotomy-associated cardiogenic shock. We are seeking the submission of original research articles discussing the physiology and physiopathology of the application of tMCS, and articles that discuss fundamental and clinical research areas related to this topic.

You may choose our Joint Special Issue in Journal of Clinical Medicine.

Dr. Raphaël Giraud
Dr. Benjamin Assouline
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extracorporeal life support
  • venoarterial extra corporeal membrane oxygenation
  • cardiogenic shock
  • septic cardiomyopathy
  • transplant
  • acute liver failure
  • obstetric catastrophes
  • heart left ventricle venting

Published Papers (1 paper)

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Research

13 pages, 535 KiB  
Article
Predictors of Mortality in Acute Myocardial Infarction Complicated by Cardiogenic Shock despite Intra-Aortic Balloon Pump: Opportunities for Advanced Mechanical Circulatory Support in Asia
by Weiqin Lin, Alfred Chung Lum Yip, Robin Cherian, Siew Pang Chan, Lauren Kay Mance Evangelista, Novi Yanti Sari, Hwei Sung Ling, Yoke Ching Lim, Raymond Ching Chiew Wong, Benjamin Wei Liang Tung, Li-Ling Tan, Adrian F. Low, Anand Adinath Ambhore and Shir Lynn Lim
Life 2024, 14(5), 577; https://doi.org/10.3390/life14050577 - 30 Apr 2024
Viewed by 285
Abstract
Introduction: Acute myocardial infarction complicated by cardiogenic shock (AMI-CS) mortality remains high despite revascularization and the use of the intra-aortic balloon pump (IABP). Advanced mechanical circulatory support (MCS) devices, such as catheter-based ventricular assist devices (cVAD), may impact mortality. We aim to identify [...] Read more.
Introduction: Acute myocardial infarction complicated by cardiogenic shock (AMI-CS) mortality remains high despite revascularization and the use of the intra-aortic balloon pump (IABP). Advanced mechanical circulatory support (MCS) devices, such as catheter-based ventricular assist devices (cVAD), may impact mortality. We aim to identify predictors of mortality in AMI-CS implanted with IABP and the proportion eligible for advanced MCS in an Asian population. Methods: We retrospectively analyzed a cohort of Society for Cardiovascular Angiography and Intervention (SCAI) stage C and above AMI-CS patients with IABP implanted from 2017–2019. We excluded patients who had IABP implanted for indications other than AMI-CS. Primary outcome was 30-day mortality. Binary logistic regression was used to calculate adjusted odds ratios (aOR) for patient characteristics. Results: Over the 3-year period, 242 patients (mean age 64.1 ± 12.4 years, 88% males) with AMI-CS had IABP implanted. 30-day mortality was 55%. On univariate analysis, cardiac arrest (p < 0.001), inotrope/vasopressor use prior to IABP (p = 0.004) was more common in non-survivors. Non-survivors were less likely to be smokers (p = 0.001), had lower ejection fraction, higher creatinine/ lactate and lower pH (all p < 0.001). On multi-variate analysis, predictors of mortality were cardiac arrest prior to IABP (aOR 4.00, CI 2.28–7.03), inotrope/vasopressor prior to IABP (aOR 2.41, CI 1.18–4.96), lower arterial pH (aOR 0.02, CI 0.00–0.31), higher lactate (aOR 2.42, CI 1.00–1.19), and lower hemoglobin (aOR 0.83, CI 0.71–0.98). Using institutional MCS criteria, 106 patients (44%) would have qualified for advanced MCS. Conclusions: Early mortality in AMI-CS remains high despite IABP. Many patients would have qualified for higher degrees of MCS. Full article
(This article belongs to the Special Issue Mechanical Circulatory Support in Circulatory Failure: The State of the Art)
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