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9.6
5.4
Journals
Marine Drugs
Special Issues
Marine Extremophiles
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Marine Extremophiles

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Chemoecology for Drug Discovery".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 2009

Special Issue Editors

Prof. Dr. Maria Michela Corsaro

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Guest Editor
Department of Chemical Sciences, University of Napoli Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, I-80126 Napoli, Italy
Interests: polysaccharides and oligosaccharides; marine extremophiles; secondary metabolites; structural elucidation; physico-chemical properties; biofilm
Special Issues, Collections and Topics in MDPI journals
Dr. Angela Casillo

E-Mail Website
Guest Editor
Department of Chemical Sciences, University of Napoli Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, I-80126 Napoli, Italy
Interests: lipopolysaccharides; glycoconjugates; extracellular polysaccharide; capsular polysaccharide; NMR spectroscopy; anti-biofilm molecules; mass spectrometry; cold-adapted bacteria
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Marine environments include seas, oceans, river mouths, and salt lakes. Within marine ecosystems, there are some extreme ecological niches where microbial life is very active. In these sites, extreme conditions include high or low values of temperature, pressure, pH value, salinity, and concentrations of metals or gas. Bacteria, algae, and archaea thriving in these habitats have been named extremophiles. Due to their metabolic strategies and smart adaptations, extremophiles are a valuable source of information about the early-stage life on our planet and the pathogens emerging with the phenomenon of global sea warming. In addition, extremophiles are an untapped reservoir of low-molecular-mass molecules and polymers with unexplored activity to be exploited for industrial applications.

We are pleased to invite you to submit research articles or reviews to this Special Issue entitled “Marine Extremophiles”. Original research articles and reviews including secondary metabolites as well as the isolation , structural characterization, and biological activity of polysaccharides and glycolipids, are welcome. In addition, papers describing structures–activity relationships are especially invited.

We look forward to receiving your contributions.

Prof. Dr. Maria Michela Corsaro
Dr. Angela Casillo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • exopolysaccharides
  • secondary metabolites
  • glycolipids
  • structural characterization
  • NMR
  • bioactive compounds
  • lipopolysaccharides
  • adaptation

Published Papers (1 paper)

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Research

19 pages, 4031 KiB  
Article
Anti-Bacterial Adhesion on Abiotic and Biotic Surfaces of the Exopolysaccharide from the Marine Bacillus licheniformis B3-15
by Vincenzo Zammuto, Antonio Spanò, Eleonora Agostino, Angela Macrì, Claudia De Pasquale, Guido Ferlazzo, Maria Giovanna Rizzo, Marco Sebastiano Nicolò, Salvatore Guglielmino and Concetta Gugliandolo
Mar. Drugs 2023, 21(5), 313; https://doi.org/10.3390/md21050313 - 20 May 2023
Cited by 8 | Viewed by 1420
Abstract
The eradication of bacterial biofilm represents a crucial strategy to prevent a clinical problem associated with microbial persistent infection. In this study we evaluated the ability of the exopolysaccharide (EPS) B3-15, produced by the marine Bacillus licheniformis B3-15, to prevent the adhesion and [...] Read more.
The eradication of bacterial biofilm represents a crucial strategy to prevent a clinical problem associated with microbial persistent infection. In this study we evaluated the ability of the exopolysaccharide (EPS) B3-15, produced by the marine Bacillus licheniformis B3-15, to prevent the adhesion and biofilm formation of Pseudomonas aeruginosa ATCC 27853 and Staphylococcus aureus ATCC 29213 on polystyrene and polyvinyl chloride surfaces. The EPS was added at different times (0, 2, 4 and 8 h), corresponding to the initial, reversible and irreversible attachment, and after the biofilm development (24 or 48 h). The EPS (300 µg/mL) impaired the initial phase, preventing bacterial adhesion even when added after 2 h of incubation, but had no effects on mature biofilms. Without exerting any antibiotic activity, the antibiofilm mechanisms of the EPS were related to the modification of the (i) abiotic surface properties, (ii) cell-surface charges and hydrophobicity, and iii) cell-to-cell aggregation. The addition of EPS downregulated the expression of genes (lecA and pslA of P. aeruginosa and clfA of S. aureus) involved in the bacterial adhesion. Moreover, the EPS reduced the adhesion of P. aeruginosa (five logs-scale) and S. aureus (one log) on human nasal epithelial cells. The EPS could represent a promising tool for the prevention of biofilm-related infections. Full article
(This article belongs to the Special Issue Marine Extremophiles)
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