Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.6
5.4
Journals
Marine Drugs
Special Issues
Active Compounds from Sea Cucumber
share announcement

Active Compounds from Sea Cucumber

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 April 2020) | Viewed by 6624

Special Issue Editor

Prof. Cusimano Maria Grazia

E-Mail Website
Guest Editor
Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche
Interests: actinobacteria; endophytes; sponge-associated; antibiotics; sea cucumbers; saponins; microalgae; macroalgae

Special Issue Information

Dear Colleagues,

Sea cucumbers are marine animals with an interesting lifestyle and a unique system of defense. They have different pharmacological, nutraceutical and medicinal activities due to the remarkable differences in the type and quantity of compounds they produce. Sea cucumbers are referred to as “marine ginseng” since they have been used either whole or in part in traditional folk medicine in many Asian countries to cure diseases like rheumatoid arthritis, joint pain, tendonitis, osteoarthritis, cardiovascular, ankylosing spondylitis, arthralgia, tumors, fungal infection, gastric, impotence, frequent urination and kidney deficiency, high blood pressure and muscular disorders.

Therefore, it is recognized that these holothurians have the ability to generate a wide range of distinctive biologically and pharmacologically important compounds with diverse chemistries which include saponins (triterpene glycosides), fatty acids, lipids, minerals, carotenoids, sphingosine, bioactive proteins (enzymes, collagen, gelatine, peptides, amino acids), vitamins, carbohydrates, mucopolysaccharides, glycosaminoglycan (GAGS, chondroitin/fucan sulphates), fucoidan, phenolics and flavonoids.

This Special Issue on “Active Compounds from Sea Cucumbers” aims to collate contributions on the latest information on the discovery, characterization, biological, pharmacological and medical evaluation and modes of actions of the many compounds from sea cucumbers. The presence and power of these active ingredients have led to a rapid growth and development in various biomedical and functional food applications which are important to human health.

Prof. Cusimano Maria Grazia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Sea cucumber
  • Saponins
  • Body wall
  • Viscera
  • Cuvierian tubules
  • Fucose; mode of action
  • Carotenoid
  • Peptides
  • GAGS
  • Sphingosine

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

13 pages, 2441 KiB  
Article
Preparation of Antioxidant Peptide by Microwave- Assisted Hydrolysis of Collagen and Its Protective Effect Against H2O2-Induced Damage of RAW264.7 Cells
by Yan Li, Jie Li, Sai-Jun Lin, Zui-Su Yang and Huo-Xi Jin
Mar. Drugs 2019, 17(11), 642; https://doi.org/10.3390/md17110642 - 14 Nov 2019
Cited by 44 | Viewed by 3626
Abstract
Antioxidant peptides have elicited interest for the versatility of their use in the food and pharmaceutical industry. In the current study, antioxidant peptides were prepared by microwave-assisted alkaline protease hydrolysis of collagen from sea cucumber (Acaudina molpadioides). The results showed that [...] Read more.
Antioxidant peptides have elicited interest for the versatility of their use in the food and pharmaceutical industry. In the current study, antioxidant peptides were prepared by microwave-assisted alkaline protease hydrolysis of collagen from sea cucumber (Acaudina molpadioides). The results showed that microwave irradiation significantly improved the degree of hydrolysis of collagen and the hydroxyl radical (OH⋅) scavenging activity of hydrolysate. The content and OH⋅ scavenging activity of collagen peptides with molecular weight ≤ 1 kDa (CPS) in the hydrolysate obtained at 250 W increased significantly compared with the non-microwave-assisted control. CPS could scavenge OH⋅ and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical in a dose-dependent manner. The scavenging activity of OH⋅ and DPPH radical was 93.1% and 41.2%, respectively, at CPS concentration of 1 mg/mL. CPS could significantly promote RAW264.7 cell proliferation and reduce the Reactive Oxygen Species (ROS) level of H2O2-induced damage in RAW264.7 cells in a dose-dependent manner. Furthermore, all CPS-treated groups exhibited an increase in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and a decrease in malondialdehyde (MDA) level compared with the control. These results showed that CPS could effectively protect RAW264.7 cells from H2O2-induced damage, implying the potential utilization of CPS as a natural antioxidant for food and pharmaceutical applications. Full article
(This article belongs to the Special Issue Active Compounds from Sea Cucumber)
►▼ Show Figures

Figure 1

9 pages, 1071 KiB  
Article
Modulation of Doxorubicin Intracellular Accumulation and Anticancer Activity by Triterpene Glycoside Cucumarioside A2-2
by Ekaterina Menchinskaya, Tatiana Gorpenchenko, Alexandra Silchenko, Sergey Avilov and Dmitry Aminin
Mar. Drugs 2019, 17(11), 597; https://doi.org/10.3390/md17110597 - 23 Oct 2019
Cited by 9 | Viewed by 2692
Abstract
The effect of treatment of Ehrlich ascites carcinoma (EAC) cells with multidrug resistance by holothurian triterpene glycoside, cucumarioside A2-2 (CA2-2) was evaluated. Calcein-AM efflux assay and doxorubicin (DOX) uptake and retention measurement in cancer cells, as well as determination [...] Read more.
The effect of treatment of Ehrlich ascites carcinoma (EAC) cells with multidrug resistance by holothurian triterpene glycoside, cucumarioside A2-2 (CA2-2) was evaluated. Calcein-AM efflux assay and doxorubicin (DOX) uptake and retention measurement in cancer cells, as well as determination of DOX cytotoxic and anticancer effects were applied. Treatment of EAC cells with CA2-2 (0.01–0.1 μM) blocked Calcein-AM and DOX efflux from cancer cells and increased the accumulation and cytotoxicity of DOX in EAC cells. Moreover, pre-treatment of mice with EAC by CA2-2 (10 μg/kg/5 days, intraperitoneal injection (i.p.)), then transplantation of tumor cells into fresh animals and subsequent treatment of these mice with DOX (2 mg/kg/3 days i.p.) significantly increased average life span (ALS) of mice bearing a tumor and therefore boosted the antitumor effect of doxorubicin in vivo. Full article
(This article belongs to the Special Issue Active Compounds from Sea Cucumber)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop