Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.6
5.4
Journals
Marine Drugs
Special Issues
Synthesis of Marine-Derived Bioactive Compounds
share announcement

Synthesis of Marine-Derived Bioactive Compounds

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 2258

Special Issue Editor

Dr. Lyndon West

E-Mail Website
Guest Editor
Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
Interests: synthesis of marine natural products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The chemical complexity and diverse biological activities of marine natural products have been a source of inspiration and the challenges to chemists, and accessing these distinctive three-dimensional structures presents unique research opportunities that push the boundaries of organic chemistry. Natural Product synthesis both total and partial (semi-synthesis) provides confirmation of structure and allows the ability to carry-out structure-activity relationship (SAR) studies for lead optimization, together with providing a potential solution to the supply issue that has curtailed the development of many marine natural products. The aim of this Special Issue is to highlight the chemical and biological discoveries resulting from the total synthesis or semi-synthesis of marine-derived natural products. We invite scientists in the fields of chemistry, biochemistry, pharmacology, and toxicology to submit review papers or original articles where synthesis has contributed to the field of marine natural products drug discovery.

Dr. Lyndon West
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Marine natural product
  • Total synthesis
  • Biomimetic synthesis
  • Semi-synthesis
  • Chemical transformation
  • Structure-activity relationship
  • Lead optimization
  • Pharmacology

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

17 pages, 4618 KiB  
Article
Synthesis and Bioactivity of Ancorinoside B, a Marine Diglycosyl Tetramic Acid
by Kevin J. Soliga, Sofia I. Bär, Natalie Oberhuber, Haoxuan Zeng, Hedda Schrey and Rainer Schobert
Mar. Drugs 2021, 19(10), 583; https://doi.org/10.3390/md19100583 - 19 Oct 2021
Cited by 7 | Viewed by 1829
Abstract
The sponge metabolite ancorinoside B was prepared for the first time in 16 steps and 4% yield. It features a β-d-galactopyranosyl-(1→4)-β-d-glucuronic acid tethered to a d-aspartic acid-derived tetramic acid. Key steps were the synthesis of a fully protected [...] Read more.
The sponge metabolite ancorinoside B was prepared for the first time in 16 steps and 4% yield. It features a β-d-galactopyranosyl-(1→4)-β-d-glucuronic acid tethered to a d-aspartic acid-derived tetramic acid. Key steps were the synthesis of a fully protected d-lactose derived thioglycoside, its attachment to a C20-aldehyde spacer, functionalization of the latter with a terminal N-(β-ketoacyl)-d-aspartate, and a basic Dieckmann cyclization to close the pyrrolidin-2,4-dione ring with concomitant global deprotection. Ancorinoside B exhibited multiple biological effects of medicinal interest. It inhibited the secretion of the cancer metastasis-relevant matrix metalloproteinases MMP-2 and MMP-9, and also the growth of Staphylococcus aureus biofilms by ca 87% when applied at concentrations as low as 0.5 µg/mL. This concentration is far below its MIC of ca 67 µg/mL and thus unlikely to induce bacterial resistance. It also led to a 67% dispersion of preformed S. aureus biofilms when applied at a concentration of ca 2 µg/mL. Ancorinoside B might thus be an interesting candidate for the control of the general hospital, catheter, or joint protheses infections. Full article
(This article belongs to the Special Issue Synthesis of Marine-Derived Bioactive Compounds)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop