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9.6
5.4
Journals
Marine Drugs
Special Issues
Antiviral Compounds from Marine Resources
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Antiviral Compounds from Marine Resources

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (1 August 2018) | Viewed by 3955

Special Issue Editor

Prof. Dr. Yuanan Lu

E-Mail Website
Guest Editor
Environmental Health Laboratory, Department of Public Health Sciences, University of Hawaii, 1960 East West Road, Biomed D104J, Honolulu, HI 96822, USA
Interests: marine natural compounds; antiviral agents; in vitro toxicology; virological assays
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Many viruses are highly pathogenic and can cause a variety of serious infections and human deaths. In addition, viruses can also infect livestock and marine species, causing huge losses of many vertebrate food species. However, available treatments for viral infections are limited. In particular, diseases caused by pathogenic viruses have shown the need for new medicines, due to emerging and re-emerging viral pathogens, and the increasing appearance of viral resistance to available treatments. Thus, effective control of viral infections and disease has remained an unachieved goal and is paramount. This Special Issue is aimed at collecting new information from present research on natural extracts and synthetic compounds with antiviral potentials, in order to facilitate the discovery and development of new antiviral drugs for enhanced treatment of viral diseases worldwide.

Prof. Dr. Yuanan Lu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Marine microorganism

  • Antiviral drugs

  • Viral resistance

  • Marine biotechnology

  • Viral infection

Published Papers (1 paper)

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Research

13 pages, 3156 KiB  
Article
Multiple Isoforms of Anti-Lipopolysaccharide Factors and Their Antimicrobial Functions in the Ridgetail Prawn Exopalaemon carinicauda
by Xinjia Lv, Shihao Li, Chengsong Zhang, Jianhai Xiang and Fuhua Li
Mar. Drugs 2018, 16(5), 145; https://doi.org/10.3390/md16050145 - 27 Apr 2018
Cited by 10 | Viewed by 3582
Abstract
As a kind of antimicrobial peptides (AMP) in crustacean, anti-lipopolysaccharide factors (ALFs) have broad spectrum antimicrobial activities. In the present study, we identified four ALF genes, EcALF2-5, from the ridgetail prawn Exopalaemon carinicauda. Tissue distribution analysis showed that EcALF2 and EcALF4 [...] Read more.
As a kind of antimicrobial peptides (AMP) in crustacean, anti-lipopolysaccharide factors (ALFs) have broad spectrum antimicrobial activities. In the present study, we identified four ALF genes, EcALF2-5, from the ridgetail prawn Exopalaemon carinicauda. Tissue distribution analysis showed that EcALF2 and EcALF4 transcripts were mainly located in gill, epidermis, and stomach, while EcALF3 and EcALF5 were mainly in hemocytes. Peptides corresponding to the LPS binding domain (LBD) of EcALFs were synthesized for analyzing their antimicrobial activities. Minimal inhibitory concentration (MIC) analysis showed that the synthetic LBD peptides of EcALF3 and EcALF4 could inhibit the growth of Gram-positive and Gram-negative bacteria, while the synthetic LBD peptides of EcALF2 and EcALF5 showed antibacterial activity against Vibrio. Incubation of white spot syndrome virus (WSSV) with the synthetic LBD peptides of EcALF3, EcALF4, and EcALF5 could reduce the in vivo viral copy number in WSSV-infected prawns. After silencing of EcALFs, Vibrio exhibited a rapid proliferation in the hepatopancreas of the prawn. The present data showed the important function of different EcALFs in modulating the in vivo bacterial and viral propagation in E. carinicauda. This study will provide new clues into the disease control in aquaculture. Full article
(This article belongs to the Special Issue Antiviral Compounds from Marine Resources)
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