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Marine Drugs
Special Issues
Biomedical and Biotechnological Applications of Marine Carbohydrate-Based Polymers
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Biomedical and Biotechnological Applications of Marine Carbohydrate-Based Polymers

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (15 October 2021) | Viewed by 6187

Special Issue Editors

Dr. Cláudia Nunes

E-Mail Website
Guest Editor
CICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro, Portugal
Interests: polysaccharides chemistry; structural analysis; polysaccharides-based materials; bionanocomposites; biological properties
Special Issues, Collections and Topics in MDPI journals
Dr. Rita Mota

E-Mail Website
Guest Editor
i3S – Institute for Research and Innovation in Health / IBMC – Institute of Molecular and Cellular Biology, University of Porto, Portugal
Interests: cyanobacteria and microalgae; extracellular polymeric substances; biopolymers; marine biotechnology; biomedical applications; bioremediation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The marine environment is a prolific source of organisms that are producers of carbohydrate polymers with distinctive characteristics. Moreover, marine polymers can provide a constant supply of raw material and, if necessary, physical or chemical modifications can enhance diversity further and ensure the requirements for a specific application. These polymers have a wide range of possible applications, extending from biomedicine (e.g., antibacterial, anti-adhesive, antiviral, and anticancer activities) to biotechnology (e.g., bioremediation, rheology modifiers, and soil conditioners).

This Special Issue will include recent advances in the discovery of marine carbohydrate polymers with significant potential for biomedical or biotechnological applications. Papers describing the physicochemical and functional characteristics of the marine polymers and the structure–activity relationship are encouraged.

Dr. Cláudia Nunes
Dr. Rita Mota
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biopolymers
  • biomedicine
  • blue biotechnology
  • marine organisms
  • structure-activity relationship
  • carbohydrate polymers

Published Papers (2 papers)

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17 pages, 5428 KiB  
Article
Enzymatic Degradation of Gracilariopsis lemaneiformis Polysaccharide and the Antioxidant Activity of Its Degradation Products
by Tian Fang, Xiaoqian Zhang, Shanshan Hu, Yanyan Yu, Xue Sun and Nianjun Xu
Mar. Drugs 2021, 19(5), 270; https://doi.org/10.3390/md19050270 - 12 May 2021
Cited by 12 | Viewed by 2434
Abstract
Gracilariopsis lemaneiformis polysaccharides (GLP) were degraded using pectinase, glucoamylase, cellulase, xylanase, and β-dextranase into low-molecular-weight polysaccharides, namely, GPP, GGP, GCP, GXP, and GDP, respectively, and their antioxidant capacities were investigated. The degraded GLP showed higher antioxidant activities than natural GLP, and GDP exhibited [...] Read more.
Gracilariopsis lemaneiformis polysaccharides (GLP) were degraded using pectinase, glucoamylase, cellulase, xylanase, and β-dextranase into low-molecular-weight polysaccharides, namely, GPP, GGP, GCP, GXP, and GDP, respectively, and their antioxidant capacities were investigated. The degraded GLP showed higher antioxidant activities than natural GLP, and GDP exhibited the highest antioxidant activity. After the optimization of degradation conditions through single-factor and orthogonal optimization experiments, four polysaccharide fractions (GDP1, GDP2, GDP3, and GDP4) with high antioxidant abilities (hydroxyl radical scavenging activity, DPPH radical scavenging activity, reduction capacity, and total antioxidant capacity) were obtained. Their cytoprotective activities against H2O2-induced oxidative damage in human fetal lung fibroblast 1 (HFL1) cells were examined. Results suggested that GDP pretreatment can significantly improve cell viability, reduce reactive oxygen species and malonaldehyde levels, improve antioxidant enzyme activity and mitochondria membrane potential, and alleviate oxidative damage in HFL1 cells. Thus, the enzyme degradation of GLP with β-dextranase can significantly improve its antioxidant activity, and GDP might be a suitable source of natural antioxidants. Full article
(This article belongs to the Special Issue Biomedical and Biotechnological Applications of Marine Carbohydrate-Based Polymers)
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12 pages, 3271 KiB  
Article
Biocompatibility of the Biopolymer Cyanoflan for Applications in Skin Wound Healing
by Raquel Costa, Luís Costa, Ilda Rodrigues, Catarina Meireles, Raquel Soares, Paula Tamagnini and Rita Mota
Mar. Drugs 2021, 19(3), 147; https://doi.org/10.3390/md19030147 - 11 Mar 2021
Cited by 12 | Viewed by 3136
Abstract
There is a great demand for the development of novel wound dressings to overcome the time and costs of wound care performed by a vast number of clinicians, especially in the current overburdened healthcare systems. In this study, Cyanoflan, a biopolymer secreted by [...] Read more.
There is a great demand for the development of novel wound dressings to overcome the time and costs of wound care performed by a vast number of clinicians, especially in the current overburdened healthcare systems. In this study, Cyanoflan, a biopolymer secreted by a marine unicellular cyanobacterium, was evaluated as a potential biomaterial for wound healing. Cyanoflan effects on cell viability, apoptosis, and migration were assessed in vitro, while the effect on tissue regeneration and biosafety was evaluated in healthy Wistar rats. The cell viability and apoptosis of fibroblasts and endothelial cells was not influenced by the treatment with different concentrations of Cyanoflan, as observed by flow cytometry. Moreover, the presence of Cyanoflan did not affect cell motility and migratory capacity, nor did it induce reactive oxygen species production, even revealing an antioxidant behavior regarding the endothelial cells. Furthermore, the skin wound healing in vivo assay demonstrated that Cyanoflan perfectly adapted to the wound bed without inducing systemic or local oxidative or inflammatory reaction. Altogether, these results suggest that Cyanoflan is a promising biopolymer for the development of innovative applications to overcome the many challenges that still exist in skin wound healing. Full article
(This article belongs to the Special Issue Biomedical and Biotechnological Applications of Marine Carbohydrate-Based Polymers)
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