Special Issue "Marine Alkaloids"
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (15 September 2010)
Prof. Dr. Mercedes Álvarez (Website)
Institute for Research in Biomedicine (IRB Barcelona), Parc Científic de Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain
Fax: +34 93 403 71 26
Interests: marine natural products; bioactive natural products; alkaloids; synthesis; heterocycles
During the last thirty years an important number of secondary methabolites whith poliheterocyclic structure have been isolated from marine sources. This special issue will focus on the chemistry of marine alkaloids from diverse marine sources ranging from sponges, soft corals, tunicates, and other marine invertebrates. Yondelis® (trabectedin) is an antitumour agent of marine origin discovered in the colonial tunicate Ecteinascidia turbinate. It received marketing authorisation from the European Commission for the treatment of several cancer illness. It is currently produced by chemical synthesis. Yondelis® has a unique action mechanism. It binds to the minor groove of the DNA and interferes with cell division and the gene transcription processes and repair machinery of the DNA. The Issue entitled Marine Alkaloids will cover aspects as isolation, characterization, structure determination, activity, total synthesis, and mechanism of action of that family of compounds.
Prof. Dr. Mercedes Álvarez
- marine alkaloid