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Spotlight on Bioactive Glasses
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Spotlight on Bioactive Glasses

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 February 2024) | Viewed by 4223

Special Issue Editor

Prof. Dr. Valeria Cannillo

E-Mail Website
Guest Editor
Department of Engineering “Enzo Ferrari”, University of Modena and Reggio Emilia, Modena, Italy
Interests: biomaterials; bioactive glasses; composites; surface coatings; materials modeling
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioactive glasses are receiving increasing attention due to their extraordinary properties. In fact, the demand for new materials suitable for the healing of tissue and bone is dramatically increasing due to world population ageing. For this reason, in the last several decades, several studies have attempted to produce high-performance materials with enhanced biological responses.

Bioactive glasses are an attractive choice because they are typically able to bond to bone more rapidly than other bioceramics. Since their discovery, bioactive glasses have opened unimaginable scenarios in the field of tissue regeneration, mainly thanks to their osteoinductive and osteoconductive characteristics, and due to their capability of bonding to soft connective tissues.

Moreover, it is possible to tailor the properties of such materials by selectively varying the composition, and thus controlling the degradation rate in accordance with the rate of new tissue formation. Furthermore, the addition of specific ions can have a beneficial effect, for example, in terms of antibacterial properties. Additionally, bioactive glasses can promote angiogenesis, neovascularization, osteoblasts proliferation, new bone growth, hemostasis, and even wound healing.

The combination, by varying the volume fractions of the two constituents, of bioactive glasses with other materials (e.g., polymers) opens up new possibilities for the production of hybrid composites with properties tailored for specific clinical applications.

Bioglasses and their related composites can be produced in various forms, such as granules, scaffolds, moldable implants, and surface coatings, that are useful for many applications in tissue engineering and regenerative medicine.

For these reasons, it is my immense pleasure to invite you to submit a manuscript to this Special Issue. Full research articles, short communications, and reviews are welcome that are related to topics including but not limited to the following: design and production of innovative bioactive glasses and/or their related composites, in vivo and in vitro studies, properties characterization and modeling, and the functionalization of these systems.

Prof. Dr. Valeria Cannillo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive glasses
  • bioactive composites
  • scaffolds
  • surface coatings
  • in vivo and in vitro tests
  • additive manufacturing
  • materials modeling
  • tissue engineering
  • regenerative medicine
  • drug delivery

Published Papers (3 papers)

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Research

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11 pages, 1203 KiB  
Article
The Impact of 45S5-Bioactive Glass on Synovial Cells in Knee Osteoarthritis—An In Vitro Study
by Hadrian Platzer, Max Marinescu, Qaisar Nawaz, Elena Tripel, Simone Gantz, Axel Horsch, Volker Daniel, Aldo R. Boccaccini, Sébastien Hagmann, Babak Moradi, Tobias Renkawitz and Fabian Westhauser
Materials 2023, 16(24), 7594; https://doi.org/10.3390/ma16247594 - 11 Dec 2023
Viewed by 1032
Abstract
Synovial inflammation in osteoarthritis (OA) is characterized by the release of cartilage-degrading enzymes and inflammatory cytokines. 45S5-bioactive glass (45S5-BG) can modulate inflammation processes; however, its influence on OA-associated inflammation has hardly been investigated. In this study, the effects of 45S5-BG on the release [...] Read more.
Synovial inflammation in osteoarthritis (OA) is characterized by the release of cartilage-degrading enzymes and inflammatory cytokines. 45S5-bioactive glass (45S5-BG) can modulate inflammation processes; however, its influence on OA-associated inflammation has hardly been investigated. In this study, the effects of 45S5-BG on the release of cartilage-degrading metalloproteinases and cytokines from synovial membrane cells (SM) isolated from patients with knee OA was assessed in vitro. SM were cultivated as SM monocultures in the presence or absence of 45S5-BG. On day 1 (d1) and d7 (d7), the concentrations of Matrix Metalloproteinases (MMPs) and cytokines were assessed. In 45S5-BG-treated SM cultures, MMP9 concentration was significantly reduced at d1 and d7, whilst MMP13 was significantly increased at d7. Concentrations of interleukin (IL)-1B and C-C motif chemokine ligand 2 (CCL2) in 45S5-BG-treated SM cultures were significantly increased at both time points, as were interferon gamma (IFNG) and IL-6 at d7. Our data show an effect of 45S5-BG on SM activity, which was not clearly protective, anti-inflammatory, or pro-inflammatory. The influence of 45S5-BG on MMP release was more suggestive of a cartilage protective effect, but 45S5-BG also increased the release of pro-inflammatory cytokines. Further studies are needed to analyze the effect of BGs on OA inflammation, including the anti-inflammatory modification of BG compositions. Full article
(This article belongs to the Special Issue Spotlight on Bioactive Glasses)
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13 pages, 1954 KiB  
Article
Adhesive Bioinspired Coating for Enhancing Glass-Ceramics Scaffolds Bioactivity
by Devis Bellucci, Annachiara Scalzone, Ana Marina Ferreira, Valeria Cannillo and Piergiorgio Gentile
Materials 2022, 15(22), 8080; https://doi.org/10.3390/ma15228080 - 15 Nov 2022
Cited by 2 | Viewed by 1425
Abstract
Bioceramic scaffolds, composed of a biphasic composite containing bioactive glass and hydroxyapatite, were prepared in this work to overcome the intrinsic limits of the two components taken separately (in particular, their specific reactivities and dissolution rates, which should be tunable as a function [...] Read more.
Bioceramic scaffolds, composed of a biphasic composite containing bioactive glass and hydroxyapatite, were prepared in this work to overcome the intrinsic limits of the two components taken separately (in particular, their specific reactivities and dissolution rates, which should be tunable as a function of the given clinical requirements). To mimic the biological environment and tune the different stages of cellular response, a coating with gelatin and chondroitin sulphate via Layer-by-Layer (LbL) assembly was presented and discussed. The resulting functionalized scaffolds were affected by the coating in terms of microstructure and porosity. In addition, the LbL coating significantly enhanced the seeded cell behaviour, with high adhesion, proliferation and osteogenic activity, as revealed by the alkaline phosphatase activity and overexpression of osteopontin and osteocalcin. Full article
(This article belongs to the Special Issue Spotlight on Bioactive Glasses)
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Review

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21 pages, 2877 KiB  
Review
Cobalt-Doped Bioactive Glasses for Biomedical Applications: A Review
by Francesco Baino, Maziar Montazerian and Enrica Verné
Materials 2023, 16(14), 4994; https://doi.org/10.3390/ma16144994 - 14 Jul 2023
Cited by 3 | Viewed by 1340
Abstract
Improving angiogenesis is the key to the success of most regenerative medicine approaches. However, how and to which extent this may be performed is still a challenge. In this regard, cobalt (Co)-doped bioactive glasses show promise being able to combine the traditional bioactivity [...] Read more.
Improving angiogenesis is the key to the success of most regenerative medicine approaches. However, how and to which extent this may be performed is still a challenge. In this regard, cobalt (Co)-doped bioactive glasses show promise being able to combine the traditional bioactivity of these materials (especially bone-bonding and osteo-stimulatory properties) with the pro-angiogenic effect associated with the release of cobalt. Although the use and local delivery of Co2+ ions into the body have raised some concerns about the possible toxic effects on living cells and tissues, important biological improvements have been highlighted both in vitro and in vivo. This review aims at providing a comprehensive overview of Co-releasing glasses, which find biomedical applications as various products, including micro- and nanoparticles, composites in combination with biocompatible polymers, fibers and porous scaffolds. Therapeutic applications in the field of bone repair, wound healing and cancer treatment are discussed in the light of existing experimental evidence along with the open issues ahead. Full article
(This article belongs to the Special Issue Spotlight on Bioactive Glasses)
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