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Advances in Biomedical and Biomimetic Materials
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Advances in Biomedical and Biomimetic Materials

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 11186

Special Issue Editor

Dr. Ugo D'Amora

E-Mail Website
Guest Editor
Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, V. le J. F. Kennedy 54, Mostra d\'Oltremare, Pad. 20, 80125 Naples, Italy
Interests: biomaterial functionalization approaches; design and preparation of polymer and nanocomposite scaffolds for soft and hard tissue engineering applications using additive manufacturing techniques; and their physco-chemical; mechanical and morphological characterization
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the last decades, population aging has been dramatically increasing due to reduced fertility rates and longer lifespans. It is well known that increased global life expectancy causes a higher risk of chronic disorders, such as neurodegeneration, musculoskeletal diseases, and tumors. For this reason, research attention has been mainly focused on the design of new approaches for biomedical applications aiming at improving life quality and reducing the pain which results from age-related disorders as well as traumatic events. Starting from the basic concept of “learning from nature”, smart and multifunctional bioinspired materials have been developed. The synergistic contribution of innovative fabrication technologies, such as additive manufacturing and bio-functionalization strategies, have led to biomimetic products characterized by improved physicochemical, mechanical, and biological properties. In light of these considerations, this Special Issue invites overviews and original technical papers on the design and development of structural biomimetic materials for biomedical devices/implants, tissue-engineered scaffolds, drug delivery, medical diagnosis, and cancer therapy.

Dr. Ugo D'Amora
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical implants
  • tissue engineering
  • regenerative medicine
  • biomaterials
  • biomimetic materials
  • additive manufacturing
  • bio-functionalization strategies
  • drug delivery
  • cancer therapy

Published Papers (4 papers)

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Research

16 pages, 2723 KiB  
Article
Marine and Agro-Industrial By-Products Valorization Intended for Topical Formulations in Wound Healing Applications
by Ana-Maria Prelipcean, Andreea Iosageanu, Alexandra Gaspar-Pintiliescu, Lucia Moldovan, Oana Craciunescu, Ticuta Negreanu-Pirjol, Bogdan Negreanu-Pirjol, Raul-Augustin Mitran, Mariana Marin and Ugo D’Amora
Materials 2022, 15(10), 3507; https://doi.org/10.3390/ma15103507 - 13 May 2022
Cited by 8 | Viewed by 2152
Abstract
Over the past years, research attention has been focusing more on waste-derived, naturally derived, and renewable materials, in the view of a more sustainable economy. In this work, different topical formulations were obtained from the valorization of marine and agro-industrial by-products and the [...] Read more.
Over the past years, research attention has been focusing more on waste-derived, naturally derived, and renewable materials, in the view of a more sustainable economy. In this work, different topical formulations were obtained from the valorization of marine and agro-industrial by-products and the use of Carbopol 940 as gelling agent. In particular, the combination of extracts obtained from the marine snail, Rapanosa venosa, with Cladophora vagabunda and grape pomace extracts, was investigated for wound healing purposes. Rapana venosa has demonstrated wound healing properties and antioxidant activity. Similarly, grape pomace extracts have been shown to accelerate the healing process. However, their synergic use has not been explored yet. To this aim, four different formulations were produced. Three formulations differed for the presence of a different extract of Rapana venosa: marine collagen, marine gelatin, and collagen hydrolysate, while another formulation used mammalian gelatin as further control. Physico-chemical properties of the extracts as well as of the formulations were analyzed. Furthermore, thermal stability was evaluated by thermogravimetric analysis. Antioxidant capacity and biological behavior, in terms of cytocompatibility, wound healing, and antimicrobial potential, were assessed. The results highlighted for all the formulations (i) a good conservation and thermal stability in time, (ii) a neutralizing activity against free radicals, (iii) and high degree of cytocompatibility and tissue regeneration potential. In particular, collagen, gelatin, and collagen hydrolysate obtained from the Rapana venosa marine snail represent an important, valuable alternative to mammalian products. Full article
(This article belongs to the Special Issue Advances in Biomedical and Biomimetic Materials)
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12 pages, 2962 KiB  
Article
In Vitro Cell Interactions on PVDF Films: Effects of Surface Morphology and Polar Phase Transition
by Marco A. Alvarez-Perez, Valentina Cirillo, Maria Giovanna Pastore Carbone, Marianna Pannico, Pellegrino Musto and Vincenzo Guarino
Materials 2021, 14(18), 5232; https://doi.org/10.3390/ma14185232 - 11 Sep 2021
Viewed by 1403
Abstract
In recent years, several studies have validated the use of piezoelectric materials for in situ biological stimulation, opening new interesting insights for bio-electric therapies. In this work, we investigate the morphological properties of polyvinylidene fluoride (PVDF) in the form of microstructured films after [...] Read more.
In recent years, several studies have validated the use of piezoelectric materials for in situ biological stimulation, opening new interesting insights for bio-electric therapies. In this work, we investigate the morphological properties of polyvinylidene fluoride (PVDF) in the form of microstructured films after temperature-driven phase transition. The work aims to investigate the correlations between morphology at micrometric (i.e., spherulite size) and sub-micrometric (i.e., phase crystallinity) scale and in vitro cell response to validate their use as bio-functional interfaces for cellular studies. Morphological analyses (SEM, AFM) enabled evidence of the peculiar spherulite-like structure and the dependence of surface properties (i.e., intra-/interdomain roughness) upon process conditions (i.e., temperature). Meanwhile, chemical (i.e., FTIR) and thermal (i.e., DSC) analyses highlighted an influence of casting temperature and polymer solution on apolar to polar phases transition, thus affecting in vitro cell response. Accordingly, in vitro tests confirmed the relationship between micro/sub-microstructural properties and hMSC response in terms of adhesion and viability, thus suggesting a promising use of PVDF films to model, in perspective, in vitro functionalities of cells under electrical stimuli upon mechanical solicitation. Full article
(This article belongs to the Special Issue Advances in Biomedical and Biomimetic Materials)
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18 pages, 7253 KiB  
Article
In-Situ Synthesis and Characterization of Chitosan/Hydroxyapatite Nanocomposite Coatings to Improve the Bioactive Properties of Ti6Al4V Substrates
by Zahra Ansari, Mahdi Kalantar, Alessandra Soriente, Ines Fasolino, Mahshid Kharaziha, Luigi Ambrosio and Maria Grazia Raucci
Materials 2020, 13(17), 3772; https://doi.org/10.3390/ma13173772 - 26 Aug 2020
Cited by 16 | Viewed by 2426
Abstract
Ti6Al4V alloy is still attracting great interest because of its application as an implant material for hard tissue repair. This research aims to produce and investigate in-situ chitosan/hydroxyapatite (CS/HA) nanocomposite coatings based on different amounts of HA (10, 50 and 60 wt.%) on [...] Read more.
Ti6Al4V alloy is still attracting great interest because of its application as an implant material for hard tissue repair. This research aims to produce and investigate in-situ chitosan/hydroxyapatite (CS/HA) nanocomposite coatings based on different amounts of HA (10, 50 and 60 wt.%) on alkali-treated Ti6Al4V substrate through the sol-gel process to enhance in vitro bioactivity. The influence of different contents of HA on the morphology, contact angle, roughness, adhesion strength, and in vitro bioactivity of the CS/HA coatings was studied. Results confirmed that, with increasing the HA content, the surface morphology of crack-free CS/HA coatings changed for nucleation modification and HA nanocrystals growth, and consequently, the surface roughness of the coatings increased. Furthermore, the bioactivity of the CS/HA nanocomposite coatings enhanced bone-like apatite layer formation on the material surface with increasing HA content. Moreover, CS/HA nanocomposite coatings were biocompatible and, in particular, CS/10 wt.% HA composition significantly promoted human mesenchymal stem cells (hMSCs) proliferation. In particular, these results demonstrate that the treatment strategy used during the bioprocess was able to improve in vitro properties enough to meet the clinical performance. Indeed, it is predicted that the dense and crack-free CS/HA nanocomposite coatings suggest good potential application as dental implants. Full article
(This article belongs to the Special Issue Advances in Biomedical and Biomimetic Materials)
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16 pages, 4904 KiB  
Article
Evaluation of a Cell-Free Collagen Type I-Based Scaffold for Articular Cartilage Regeneration in an Orthotopic Rat Model
by Marta Anna Szychlinska, Giovanna Calabrese, Silvia Ravalli, Anna Dolcimascolo, Paola Castrogiovanni, Claudia Fabbi, Caterina Puglisi, Giovanni Lauretta, Michelino Di Rosa, Alessandro Castorina, Rosalba Parenti and Giuseppe Musumeci
Materials 2020, 13(10), 2369; https://doi.org/10.3390/ma13102369 - 21 May 2020
Cited by 26 | Viewed by 4180
Abstract
The management of chondral defects represents a big challenge because of the limited self-healing capacity of cartilage. Many approaches in this field obtained partial satisfactory results. Cartilage tissue engineering, combining innovative scaffolds and stem cells from different sources, emerges as a promising strategy [...] Read more.
The management of chondral defects represents a big challenge because of the limited self-healing capacity of cartilage. Many approaches in this field obtained partial satisfactory results. Cartilage tissue engineering, combining innovative scaffolds and stem cells from different sources, emerges as a promising strategy for cartilage regeneration. The aim of this study was to evaluate the capability of a cell-free collagen I-based scaffold to promote cartilaginous repair after orthotopic implantation in vivo. Articular cartilage lesions (ACL) were created at the femoropatellar groove in rat knees and cell free collagen I-based scaffolds (S) were then implanted into right knee defect for the ACL-S group. No scaffold was implanted for the ACL group. At 4-, 8- and 16-weeks post-transplantation, degrees of cartilage repair were evaluated by morphological, histochemical and gene expression analyses. Histological analysis shows the formation of fibrous tissue, at 4-weeks replaced by a tissue resembling the calcified one at 16-weeks in the ACL group. In the ACL-S group, progressive replacement of the scaffold with the newly formed cartilage-like tissue is shown, as confirmed by Alcian Blue staining. Immunohistochemical and quantitative real-time PCR (qRT-PCR) analyses display the expression of typical cartilage markers, such as collagen type I and II (ColI and ColII), Aggrecan and Sox9. The results of this study display that the collagen I-based scaffold is highly biocompatible and able to recruit host cells from the surrounding joint tissues to promote cartilaginous repair of articular defects, suggesting its use as a potential approach for cartilage tissue regeneration. Full article
(This article belongs to the Special Issue Advances in Biomedical and Biomimetic Materials)
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