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Bone Tissue Engineering Materials: From Preparation to Properties

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Special Issue Editor

Dr. Jakub Szabelski

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Guest Editor

Department of Materials Science and Engineering, Lublin University of Technology, 20-618 Lublin, Poland
Interests: biomaterials; bone cements; adhesive joints; adhesive materials

Special Issue Information

Dear Colleagues,

This Special Issue titled "Materials for Bone Tissue Engineering: From Preparation to Properties" aims to present the latest research and development progress in the field of biomaterials designed specifically for bone tissue engineering, with a special focus on bone cements. Bone cements play a key role in orthopedic surgery and are essential for implant fixation and bone reconstruction. This Special Issue will therefore cover a wide range of aspects within this topic, including the development of innovative preparation techniques and methods for evaluating the properties and durability of bone cements.

We hope that this Special Issue will be a valuable resource for researchers, engineers and clinicians interested in the latest developments and future directions of biomaterials, particularly bone cements, in bone tissue engineering.

Dr. Jakub Szabelski
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

biomaterials
bone tissue engineering
bone cements
preparation techniques
properties and performance
surface modification
material degradation
biocompatibility
mechanical strength
porosity
antibiotics
controlled release

Published Papers (2 papers)

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Research

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25 pages, 4500 KiB

Open AccessArticle

In Vivo Investigation of 3D-Printed Calcium Magnesium Phosphate Wedges in Partial Load Defects

by Elke Hemmerlein, Elke Vorndran, Anna-Maria Schmitt, Franziska Feichtner, Anja-Christina Waselau and Andrea Meyer-Lindenberg

Materials 2024, 17(9), 2136; https://doi.org/10.3390/ma17092136 - 02 May 2024

Viewed by 358

Abstract

Bone substitutes are ideally biocompatible, osteoconductive, degradable and defect-specific and provide mechanical stability. Magnesium phosphate cements (MPCs) offer high initial stability and faster degradation compared to the well-researched calcium phosphate cements (CPCs). Calcium magnesium phosphate cements (CMPCs) should combine the properties of both and have so far shown promising results. The present study aimed to investigate and compare the degradation and osseointegration behavior of 3D powder-printed wedges of CMPC and MPC in vivo. The wedges were post-treated with phosphoric acid (CMPC) and diammonium hydrogen phosphate (MPC) and implanted in a partially loaded defect model in the proximal rabbit tibia. The evaluation included clinical, in vivo µ-CT and X-ray examinations, histology, energy dispersive X-ray analysis (EDX) and scanning electron microscopy (SEM) for up to 30 weeks. SEM analysis revealed a zone of unreacted material in the MPC, indicating the need to optimize the manufacturing and post-treatment process. However, all materials showed excellent biocompatibility and mechanical stability. After 24 weeks, they were almost completely degraded. The slower degradation rate of the CMPC corresponded more favorably to the bone growth rate compared to the MPC. Due to the promising results of the CMPC in this study, it should be further investigated, for example in defect models with higher load. Full article

(This article belongs to the Special Issue Bone Tissue Engineering Materials: From Preparation to Properties)

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Review

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17 pages, 3145 KiB

Open AccessReview

Cemented vs. Cementless Fixation in Primary Knee Replacement: A Narrative Review

by Mikołaj Wilczyński, Michał Bieniek, Przemysław Krakowski and Robert Karpiński

Materials 2024, 17(5), 1136; https://doi.org/10.3390/ma17051136 - 29 Feb 2024

Viewed by 841

Abstract

Knee osteoarthritis (OA) is one of the leading causes of disability around the globe. Osteoarthritis is mainly considered a disease affecting the elderly. However, more and more studies show that sports overuse, obesity, or congenital disorders can initiate a pathologic cascade that leads to OA changes in the younger population. Nevertheless, OA mostly affects the elderly, and with increasing life expectancy, the disease will develop in more and more individuals. To date, the golden standard in the treatment of the end-stage of the disease is total joint replacement (TJR), which restores painless knee motion and function. One of the weakest elements in TJR is its bonding with the bone, which can be achieved by bonding material, such as poly methyl-methacrylate (PMMA), or by cementless fixation supported by bone ingrowth onto the endoprosthesis surface. Each technique has its advantages; however, the most important factor is the revision rate and survivor time. In the past, numerous articles were published regarding TJR revision rate, but no consensus has been established yet. In this review, we focused on a comparison of cemented and cementless total knee replacement surgeries. We introduced PICO rules, including population, intervention, comparison and outcomes of TJR in a PubMed search. We identified 783 articles published between 2010 and 2023, out of which we included 14 in our review. Our review reveals that there is no universally prescribed approach to fixate knee prostheses. The determination of the most suitable method necessitates an individualized decision-making process involving the active participation and informed consent of each patient. Full article

(This article belongs to the Special Issue Bone Tissue Engineering Materials: From Preparation to Properties)

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