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Advanced Materials for Biomedical Applications
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Advanced Materials for Biomedical Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 May 2024) | Viewed by 4287

Special Issue Editors

Dr. Ioannis Liakos

E-Mail Website
Guest Editor
Institute of Nanoscience and Nanotechnology, Building No 8, NCSR Demokritos, Neapoleos 27 & Patriarch Grigoriou E Street, Agia Paraskevi, 15341 Athens, Greece
Interests: surface chemistry; membranes; nanotechnology; renewable energy; environmental chemistry; physical chemistry
Special Issues, Collections and Topics in MDPI journals
Dr. René D. Darío Peralta-Rodríguez

E-Mail Website
Guest Editor
Polymerization Processes, Centro de Investigacion en Quimica Aplicada, Saltillo 25294, Mexico
Interests: heterophase polymerization; microemulsions; nanodevices; polymeric drug carriers; inorganic heterostructures; cancer treatment
Dr. Esmeralda Mendoza

E-Mail Website
Guest Editor
Investigadores por México, Centro de Investigación y Estudios de Posgrado, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Dr. Manuel Nava 6, San Luis Potosí 78210, Mexico
Interests: photocatalytic processes
Special Issues, Collections and Topics in MDPI journals
Dr. Fidel Martinez-Gutierrez

E-Mail Website
Guest Editor
Department of Microbiology, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78300, Mexico
Interests: antimicrobial resistance; clinical biofilm; medical devices; microbiota modulation; cellular cytotoxicity
Dr. Héctor Iván Meléndez Ortíz

E-Mail Website
Guest Editor
CONACyT, Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna Hermosillo #140, Saltillo 25294, Mexico
Interests: essential oil; nanodevices; nanoparticles; hydrogels; drug delivery; anticancer agents delivery; antibiotic delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Interdisciplinary research in the field of front-line materials in biomedical applications continues to attract the attention of pharmacists, biologists, chemists, materials scientists, engineers, clinicians and other researchers worldwide. Some areas of investigation include the development of advanced materials, i.e., smart polymers, nanostructures, hybrid materials (e.g., inorganic/organic materials), microemulsions, hydrogels, liposomes, etc. The application of these materials in the biomedical field encompasses, but is not limited to, wound healing, imaging, targeted drug delivery, scaffolds, medical devices, tissue engineering, controlled release, cancer treatment and the specific delivery of drugs for cardiovascular disease, among others.

In this Special Issue we intend to present research outcomes reporting current findings on advanced materials for biomedical applications considering their performance, healing properties and the well-being of the patients who could benefit from these cutting-edge technologies under development. The published reports are expected to inspire future research on these most exciting materials. The editorial team for this Special Issue invites contributions about novel and innovative advanced materials with applications in medicine and pharmacy as well as innovative or modified analytical techniques associated with these materials, in the form of original research articles, reviews, research notes and short communications from the scientific community.

Dr. Ioannis Liakos
Dr. René D. Darío Peralta-Rodríguez
Dr. Esmeralda Mendoza
Dr. Fidel Martinez-Gutierrez
Dr. Héctor Iván Meléndez Ortíz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • smart polymers
  • nanostructures
  • hydrogels
  • drug nanocarriers
  • nano- and microdevices
  • biopolymers
  • drug delivery
  • organic/inorganic hybrid materials
  • pharmaceutical applications

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (4 papers)

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Editorial

Jump to: Research

2 pages, 568 KiB  
Editorial
Advanced Materials for Biomedical Applications, Editorial Article
by René D. Peralta-Rodríguez, Esmeralda Mendoza-Mendoza and Ioannis L. Liakos
Materials 2024, 17(15), 3692; https://doi.org/10.3390/ma17153692 - 26 Jul 2024
Viewed by 543
Abstract
Advanced materials (AMs) encompass materials that feature improved properties compared to common counterparts [...] Full article
(This article belongs to the Special Issue Advanced Materials for Biomedical Applications)
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Research

Jump to: Editorial

12 pages, 5187 KiB  
Article
Fabrication of Magnetic Poly(L-lactide) (PLLA)/Fe3O4 Composite Electrospun Fibers
by Zhu Liu, Yufu Zheng, Lizhong Lin, Xiaofei Liu and Na Qiang
Materials 2024, 17(15), 3773; https://doi.org/10.3390/ma17153773 - 1 Aug 2024
Viewed by 724
Abstract
Electrospinning technology is widely used for preparing biological tissue engineering scaffolds because of its advantages of simple preparation, accurate process parameters, and easy control. Poly(L-lactide) (PLLA) is regarded as a promising biomass-based polymer for use in electrospinning. The incorporation of Fe3O [...] Read more.
Electrospinning technology is widely used for preparing biological tissue engineering scaffolds because of its advantages of simple preparation, accurate process parameters, and easy control. Poly(L-lactide) (PLLA) is regarded as a promising biomass-based polymer for use in electrospinning. The incorporation of Fe3O4 nanoparticles (NPs) could improve the osteogenic differentiation and proliferation of cells in the presence or absence of a static magnetic field (SMF). In this work, these two materials were blended together to obtain electrospun samples with better dispersibility and improved magnetic properties. First, composite PLLA and Fe3O4 NP fibers were prepared by means of electrospinning. The influence of electrospinning conditions on the morphology of the composite fibers was then discussed. Changes in magnetic properties and thermal stability resulting from the use of different PLLA/Fe3O4 mass ratios were also considered. Next, the morphology, crystal state, thermodynamic properties, and magnetic properties of the electrospun samples were determined using scanning electron microscopy (SEM), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and vibration sample magnetization (VSM). The results showed that the fibers prepared using PLLA with Mn = 170,000 exhibited good morphology when electrospun at 12 KV. The magnetic properties of PLLA/Fe3O4 composite electrospun fibers increased with the NP content, with the exception of thermal stability. The results of the present study may help to promote the further development of PLLA/Fe3O4 composite materials in the biomedical field. Full article
(This article belongs to the Special Issue Advanced Materials for Biomedical Applications)
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18 pages, 3963 KiB  
Article
Synthesis and In Vitro Biocompatibility Studies of Novel Alkoxy 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacenes
by Margarida G. Santos, Juliana Araújo, Chrislaura Carmo, Leonardo Santos, Maria Filomena Botelho, Mafalda Laranjo and Abílio J. F. N. Sobral
Materials 2023, 16(22), 7085; https://doi.org/10.3390/ma16227085 - 8 Nov 2023
Cited by 1 | Viewed by 943
Abstract
BODIPYs are bicyclic aromatic compounds with unique spectroscopic, photophysical, and chemical properties. This study aimed to find BODIPYs with characteristics biocompatible with human cell lines for possible use as imaging agents. Six BODIPY derivatives were synthesised with groups linked to boron, fluorine, phenol, [...] Read more.
BODIPYs are bicyclic aromatic compounds with unique spectroscopic, photophysical, and chemical properties. This study aimed to find BODIPYs with characteristics biocompatible with human cell lines for possible use as imaging agents. Six BODIPY derivatives were synthesised with groups linked to boron, fluorine, phenol, or catechol, resulting in compounds with different physicochemical characteristics. NMR, absorption, and emission spectroscopy and mass spectrometry were subsequently used to characterise them. Afterwards, the biocompatibility of these compounds was evaluated using MTT, SRB, and cellular uptake assays in A549 and H1299 cell lines. Furthermore, a haemolysis assay was performed on human blood cells. To summarise the main results, BODIPYs 1 to 4 showed considerable fluorescence. In contrast, BODIPYs 5 and 6 showed very weak fluorescence, which could be related to the presence of the catechol group and its quenching properties. Regarding biocompatibility, all compounds had metabolic activity and viability above 80% and 70%, respectively. BODIPYs 3 and 6 presented the most consistent data, demonstrating good uptake and, in general, haemolytic activity below 25%. In conclusion, the cytotoxic effects of the compounds were not considerable, and the presence of cyclic alkoxides in BODIPYs 3 and 6 may introduce exciting features that should be highlighted for dual imaging for BODIPY 3 due to its fluorescence or for radioactive labelling in the case of both BODIPYs. Full article
(This article belongs to the Special Issue Advanced Materials for Biomedical Applications)
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13 pages, 2634 KiB  
Article
Effect of Sodium Hydroxide and Tripolyphosphate on Curcumin Release from Chitosan-Based Macroparticles
by Alessandro Pistone, Annamaria de Gaetano, Elpida Piperopoulos and Chiara Abate
Materials 2023, 16(17), 5850; https://doi.org/10.3390/ma16175850 - 26 Aug 2023
Cited by 3 | Viewed by 1302
Abstract
This work deals with the synthesis of bare and curcumin (CUR)-loaded chitosan (CS)-based macroparticles by ionic gelation using sodium hydroxide (NaOH) or sodium tripolyphosphate (TPP). The resulting spherical-shaped macroparticles were studied using various characterization techniques, Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy [...] Read more.
This work deals with the synthesis of bare and curcumin (CUR)-loaded chitosan (CS)-based macroparticles by ionic gelation using sodium hydroxide (NaOH) or sodium tripolyphosphate (TPP). The resulting spherical-shaped macroparticles were studied using various characterization techniques, Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), and Differential Scanning Calorimetry (DSC). The release of CUR from the CS-based particles with respect to time was analyzed, and the encapsulation efficiency and degree of swelling were studied. All formulations showed excellent CUR trapping efficiency, exceeding 90%. In particular, the TPP-crosslinked macrobeads released 34 wt% of the charged CUR within minutes, while the remaining 66 wt% was released slowly. The results indicate that the correct choice of gelling agent and its concentration leads to spherical particles capable of encapsulating CUR and releasing it in a wide range of kinetics so that macrospheres can be used in different applications. Full article
(This article belongs to the Special Issue Advanced Materials for Biomedical Applications)
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