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Advanced Materials and Systems for Biomedical Application
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Advanced Materials and Systems for Biomedical Application

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 August 2022) | Viewed by 10896

Special Issue Editor

Dr. Ki Su Kim

E-Mail Website
Guest Editor
School of Chemical Engineering, College of Engineering, Pusan National University, Busan 46241, Republic of Korea
Interests: biomaterials; biomedical application; theranostics; nanomedicine; biosensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently, interest in healthcare has been increased. To this end, drug delivery, tissue engineering, biosensors for diagnosis, and treatment of diseases has been widely investigated using materials including metals, ceramics, and polymers for biomedical application. With developing novel therapeutics, these materials systems are evolving for covering diagnosis and treatment of incurable diseases such as cancer or degenerative diseases. In addition, incorporated with nanotechnology, nanomedicine systems have also been studied for developing drug carriers, tissue scaffolds, and healthcare devices. However, people still suffer from various diseases and want to develop novel and advanced systems for taking care of human diseases.

Therefore, this Special Issue of Materials will collect original high-quality research papers covering the most recent advances and comprehensive reviews addressing state-of-the-art topics in the field of various materials and systems for the current and futuristic biomedical applications.

Prof. Dr. Ki Su Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biomaterials
  • Bioengineering
  • Biomedical application
  • Theranosis (diagnosis and therapy)
  • Drug delivery
  • Tissue engineering
  • Biosensors

Published Papers (5 papers)

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Research

8 pages, 1581 KiB  
Article
Stretchable and Conductive Cellulose/Conductive Polymer Composite Films for On-Skin Strain Sensors
by Joo Won Han, Jihyun Park, Jung Ha Kim, Siti Aisyah Nurmaulia Entifar, Ajeng Prameswati, Anky Fitrian Wibowo, Soyeon Kim, Dong Chan Lim, Jonghee Lee, Myoung-Woon Moon, Min-Seok Kim and Yong Hyun Kim
Materials 2022, 15(14), 5009; https://doi.org/10.3390/ma15145009 - 19 Jul 2022
Cited by 3 | Viewed by 1987
Abstract
Conductive composite materials have attracted considerable interest of researchers for application in stretchable sensors for wearable health monitoring. In this study, highly stretchable and conductive composite films based on carboxymethyl cellulose (CMC)-poly (3,4-ethylenedioxythiopehe):poly (styrenesulfonate) (PEDOT:PSS) (CMC-PEDOT:PSS) were fabricated. The composite films achieved excellent [...] Read more.
Conductive composite materials have attracted considerable interest of researchers for application in stretchable sensors for wearable health monitoring. In this study, highly stretchable and conductive composite films based on carboxymethyl cellulose (CMC)-poly (3,4-ethylenedioxythiopehe):poly (styrenesulfonate) (PEDOT:PSS) (CMC-PEDOT:PSS) were fabricated. The composite films achieved excellent electrical and mechanical properties by optimizing the lab-synthesized PEDOT:PSS, dimethyl sulfoxide, and glycerol content in the CMC matrix. The optimized composite film exhibited a small increase of only 1.25-fold in relative resistance under 100% strain. The CMC-PEDOT:PSS composite film exhibited outstanding mechanical properties under cyclic tape attachment/detachment, bending, and stretching/releasing tests. The small changes in the relative resistance of the films under mechanical deformation indicated excellent electrical contacts between the conductive PEDOT:PSS in the CMC matrix, and strong bonding strength between CMC and PEDOT:PSS. We fabricated highly stretchable and conformable on-skin sensors based on conductive and stretchable CMC-PEDOT:PSS composite films, which can sensitively monitor subtle bio-signals and human motions such as respiratory humidity, drinking water, speaking, skin touching, skin wrinkling, and finger bending. Because of the outstanding electrical properties of the films, the on-skin sensors can operate with a low power consumption of only a few microwatts. Our approach paves the way for the realization of low-power-consumption stretchable electronics using highly stretchable CMC-PEDOT:PSS composite films. Full article
(This article belongs to the Special Issue Advanced Materials and Systems for Biomedical Application)
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12 pages, 2238 KiB  
Article
Spatially Ordered Arrays of Colloidal Inorganic Metal Halide Perovskite Nanocrystals via Controlled Droplet Evaporation in a Confined Geometry
by Kwan Lee, Jonghyun Moon, Jeonghwa Jeong and Suck Won Hong
Materials 2021, 14(22), 6824; https://doi.org/10.3390/ma14226824 - 12 Nov 2021
Cited by 1 | Viewed by 2053
Abstract
Inorganic metal halide perovskite nanocrystals, such as quantum dots (QDs), have emerged as intriguing building blocks for miniaturized light-emitting and optoelectronic devices. Although conventional lithographic approaches and printing techniques allow for discrete patterning at the micro/nanoscale, it is still important to utilize intrinsic [...] Read more.
Inorganic metal halide perovskite nanocrystals, such as quantum dots (QDs), have emerged as intriguing building blocks for miniaturized light-emitting and optoelectronic devices. Although conventional lithographic approaches and printing techniques allow for discrete patterning at the micro/nanoscale, it is still important to utilize intrinsic QDs with the concomitant retaining of physical and chemical stability during the fabrication process. Here, we report a simple strategy for the evaporative self-assembly to produce highly ordered structures of CsPbBr3 and CsPbI3 QDs on a substrate in a precisely controllable manner by using a capillary-bridged restrict geometry. Quantum confined CsPbBr3 and CsPbI3 nanocrystals, synthesized via a modified hot-injection method with excess halide ions condition, were readily adapted to prepare colloidal QD solutions. Subsequently, the spatially patterned arrays of the perovskite QD rings were crafted in a confirmed geometry with high fidelity by spontaneous solvent evaporation. These self-organized concentric rings were systemically characterized regarding the center-to-center distance, width, and height of the patterns. Our results not only facilitate a fundamental understanding of assembly in the perovskite QDs to enable the solution-printing process but also provide a simple route for offering promising practical applications in optoelectronics. Full article
(This article belongs to the Special Issue Advanced Materials and Systems for Biomedical Application)
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11 pages, 1343 KiB  
Article
Enhanced Cellular Cryopreservation by Biopolymer-Associated Suppression of RhoA/ROCK Signaling Pathway
by Tae Wook Lee, Gyeong Won Lee, Seonyeong An, Keum-Yong Seong, Jong Soo Lee and Seung Yun Yang
Materials 2021, 14(20), 6056; https://doi.org/10.3390/ma14206056 - 14 Oct 2021
Cited by 3 | Viewed by 1843
Abstract
With increasing demands on long-term storage of cells, cryopreservation of cells is gaining more importance in cell-based research and applications. Dimethyl sulfoxide (DMSO) is a commonly used chemical cryoprotectant, providing increased cell survival during the freezing process. However, its use is limited in clinical [...] Read more.
With increasing demands on long-term storage of cells, cryopreservation of cells is gaining more importance in cell-based research and applications. Dimethyl sulfoxide (DMSO) is a commonly used chemical cryoprotectant, providing increased cell survival during the freezing process. However, its use is limited in clinical applications due to its low biocompatibility above cryogenic temperatures. Herein, we present a new approach for reducing the use of DMSO in cryopreservation by using biodegradable hyaluronic acids (HAs). By adding HAs into cryoprotectant media containing a low concentration of DMSO, higher cell viability and cell proliferation rate were observed upon thawing after cryopreservation. The HA-supplemented cryopreservation media did not reduce the size of the ice crystal, which significantly influenced cell viability during cell freezing, but decreased the Ras homolog family member A (RhoA)/Rho-associated protein kinase (ROCK) signaling pathway related to apoptosis. The cell-interactive cryoprotectants containing HA can be applied to the development of a new cryoprotectant that reduces the adverse effect of DMSO. Full article
(This article belongs to the Special Issue Advanced Materials and Systems for Biomedical Application)
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11 pages, 5546 KiB  
Communication
Detonation Spraying of Hydroxyapatite on a Titanium Alloy Implant
by Natalia V. Bulina, Denis K. Rybin, Svetlana V. Makarova, Dina V. Dudina, Igor S. Batraev, Alexey V. Utkin, Igor Yu. Prosanov, Mikhail V. Khvostov and Vladimir Yu. Ulianitsky
Materials 2021, 14(17), 4852; https://doi.org/10.3390/ma14174852 - 26 Aug 2021
Cited by 9 | Viewed by 1664
Abstract
Hydroxyapatite (HA), the major mineral component of tooth enamel and natural bones, is a good candidate for bone tissue engineering. Synthetic HA is used for making coatings on metallic implants intended for medical applications. A HA coating renders the implant biocompatible and osteoinductive. [...] Read more.
Hydroxyapatite (HA), the major mineral component of tooth enamel and natural bones, is a good candidate for bone tissue engineering. Synthetic HA is used for making coatings on metallic implants intended for medical applications. A HA coating renders the implant biocompatible and osteoinductive. In addition, it improves fixation and the overall performance of the implanted object. In the present work, HA coatings were deposited on a medical titanium alloy implant with mesh geometry and a developed surface by detonation spraying. The feedstock powder was HA obtained by the dry mechanochemical method. Single-phase HA coatings were obtained. The coatings were formed not only on the surfaces normal to the particle flow direction, but also on the sides of the mesh elements. Despite partial melting of the powder, no decomposition of HA occurred. This work demonstrates the prospects of detonation spraying for the production of HA coatings on metallic implants with complex geometries. Full article
(This article belongs to the Special Issue Advanced Materials and Systems for Biomedical Application)
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9 pages, 11641 KiB  
Communication
Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry
by Hyunsik Choi, Mina Kwon, Hye Eun Choi, Sei Kwang Hahn and Ki Su Kim
Materials 2021, 14(6), 1504; https://doi.org/10.3390/ma14061504 - 18 Mar 2021
Cited by 9 | Viewed by 2628
Abstract
Hyaluronate (HA) has been widely investigated for noninvasive topical drug delivery of chemical drugs and biopharmaceuticals. However, previous noninvasive delivery systems have been facilitated mostly by chemical conjugation of drugs with HA, which can cause reduced therapeutic efficacy and safety issues in chemically [...] Read more.
Hyaluronate (HA) has been widely investigated for noninvasive topical drug delivery of chemical drugs and biopharmaceuticals. However, previous noninvasive delivery systems have been facilitated mostly by chemical conjugation of drugs with HA, which can cause reduced therapeutic efficacy and safety issues in chemically modified drugs. Here, HA nanogels were synthesized by crosslinking via “click” chemistry for noninvasive topical delivery of a model drug without chemical modification. The model-drug-encapsulating HA nanogels could be uptaken to the skin melanoma cells in vitro by HA-mediated endocytosis. In addition, histological analysis showed that HA nanogels could be topically delivered to the deep skin and tongue tissues through the noninvasive delivery routes. Taken together, HA nanogels could be effectively used for the noninvasive topical delivery of various therapeutic drugs. Full article
(This article belongs to the Special Issue Advanced Materials and Systems for Biomedical Application)
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