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Nanoparticles for Biological Imaging and Treatment Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 2810

Special Issue Editor


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Guest Editor
Department of Biomedical Engineering, Tel Aviv University, Tel-Aviv 6997801, Israel.
The Malone Center for Engineering in Healthcare (https://malonecenter.jhu.edu)
Department of Electrical and Computer Engineering, Whiting School of Engineering; Department of Biomedical Engineering; School of Medicine Johns Hopkins University, Baltimore MD
Interests: theranostics; laser tissue interactions; multimodal imaging snd treatment; design of biomedical instruments and systems; practical ethics

Special Issue Information

Dear Colleagues,

The progress in nanotechnology, wave propagation in tissue, and understanding of disease biological markers enables new and powerful methods for early detection, treatment, and monitoring. It is now possible to fabricate different types and shapes of uniform nanoparticles: nanospheres, nanorods, and nanocages. They can also be biocompatible. These particles can be functionalized so they can specifically bind to disease markers. They can be adhered to surfaces such as fiber tips and band-aids. It is possible to manipulate them and drive them to certain areas within the body, and they can be used as a conversion mechanism from one energy type to another. Nanoparticles can be magnetic superparamagnetics. They can emit different wavelengths of light from the excitation wavelength. They can emit acoustical waves after being triggered with magnetic fields, and they can emit heat locally with magnetic or light excitation. Nanoparticles can be used for treatment by themselves or enhance chemotherapeutic agents’ effect on the disease. Nanocages can carry drugs and can release them in a controllable way in an area where they are needed. This can be done with outside energy or self-opening when in a certain conditions (i.e., pH). Various imaging modalities such as MRI, magnetic particle imaging, magnetoacoustics, thermal imaging, and other optical methods are adapted, further developed or totally new and used for nanoparticle imaging. Imaging can be done with big expensive machines or portable bedside instruments. Nanoparticles are excellent vehicles for development of theranostics applications.

This Special Issue has been created to report all these fascinating advances in medical applications. We are seeking high-level manuscripts that report the newest results in the field.

Prof. Israel Gannot
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Early diagnostics of cancer
  • Multimodal cancer imaging
  • Nanoparticle-based hyperthermia
  • Tumor-immune response
  • Immunotherapy
  • Nanoparticle functionalization
  • Specific binding
  • Enhanced chemotherapy
  • Temperature
  • Functional imaging
  • Nanorods
  • Nanocages
  • Antibody–antigen reaction
  • Tumor localization
  • Nanoparticle manipulation
  • Heat transfer in tissue around tumors
  • Functional imaging of tumors

Published Papers (1 paper)

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Research

13 pages, 2426 KiB  
Article
Diffusion Reflection Measurements of Antibodies Conjugated to Gold Nanoparticles as a Method to Identify Cutaneous Squamous Cell Carcinoma Borders
by Asaf Olshinka, Dean Ad-El, Elena Didkovski, Shirel Weiss, Rinat Ankri, Nitza Goldenberg-Cohen and Dror Fixler
Materials 2020, 13(2), 447; https://doi.org/10.3390/ma13020447 - 17 Jan 2020
Cited by 4 | Viewed by 2570
Abstract
Diffusion reflectance spectroscopy measurements targeted with gold nanoparticles (GNPs) can identify residual cutaneous squamous cell carcinoma (SCC) in excision borders. Human SCC specimens were stained with hematoxylin and eosin to identify tumor borders, and reflected onto an unstained deparaffinized section. Diffusion reflection of [...] Read more.
Diffusion reflectance spectroscopy measurements targeted with gold nanoparticles (GNPs) can identify residual cutaneous squamous cell carcinoma (SCC) in excision borders. Human SCC specimens were stained with hematoxylin and eosin to identify tumor borders, and reflected onto an unstained deparaffinized section. Diffusion reflection of three sites (normal and SCC) were measured before and after GNPs targeting. Hyperspectral imaging showed a mean of 2.5 sites with tumor per specimen and 1.2 tumor-free (p < 0.05, t-test). GNPs were detected in 25/30 tumor sites (sensitivity 83.3%, false-negative rate 16.6%) and 12/30 non-tumor sites (specificity 60%, false-positive rate 40%). This study verifies the use of nanotechnology in identifying SCC tumor margins. Diffusion reflection scanning has high sensitivity for detecting the residual tumor. Full article
(This article belongs to the Special Issue Nanoparticles for Biological Imaging and Treatment Applications)
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