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Bioactive Glass-Based Materials for Soft and Hard Tissue Regeneration: A New Future for Dental and Biomedical Applications

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A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 20 June 2024 | Viewed by 2795

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Special Issue Editors

Dr. Nina Attik

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Guest Editor

Faculté d'Odontologie (LMI UMR CNRS 5615), 11 Rue Guillaume Paradin, 69372 Lyon, CEDEX 08, France
Interests: dental materials; bioactivity; tissue preservation; toxicity; cells; implants; periodontal regeneration

Dr. Rémy Gauthier

E-Mail Website
Guest Editor

MatéIS UMR 5510, CNRS - INSA Lyon - Université Claude Bernard Lyon 1, Villeurbanne, France
Interests: dental

Special Issue Information

Dear Colleagues,

Since the introduction of bioactive glasses (BAGs) by Professor Larry Hench in 1969, the development of BAG-based materials for tissue regeneration continues to rise. Initially, BAGs were used in medical applications due to their ability to form a bond with bone, stimulating its self-healing potential. With time, the evolution of BAG compositions and manufacturing methods has led to a better control of the mesoporous structure, particle size, and the delivery of therapeutic ions or active molecules. In this respect, the investigation of BAGs has extended to a large number of biomaterials, such as bone cements and implant coatings. In dentistry, BAGs have been investigated as dental cements and added to restorations and even toothpaste. For both clinicians and researchers involved in minimally invasive therapies and tissue preservation, BAG-based materials represent an interesting regenerative strategy, especially for soft/hard biological interface regeneration, such as in dental applications. This Special Issue, entitled “Bioactive Glass-Based Materials for Soft and Hard Tissue Regeneration: A New Future for Dental and Biomedical Applications,” is dedicated to advances in the field of bioactive glasses, targeting both dental and biomedical applications. Studies on all types of BAG-based materials are welcome in the form of full papers, communications, and reviews.

Dr. Nina Attik
Dr. Rémy Gauthier
Guest Editors

BG related paper:

Lizzi F, Attik N, Goutaudier C, Jackson P, Campbell I, Rizzo S, Grosgogeat B, Villat C. Experimental borosilicate bioactive glasses: Pulp cells cytocompatibility and mechanical characterization. Int. Endod. J. 2022;00:1
Dejob L, Attik N, Tadier S, Toury B, Salles V. Nitrate‐Free Synthesis and Electrospinning of Carbonated Hydroxyapatite Coatings on TA6V Implants. Advanced Materials Interfaces, 2022, pp.2102342
Attik N, Colon P, Gauthier R, Chevalier C, Grosgogeat B, Abouelleil H. Comparison of physical and biological properties of a flowable fiber reinforced and bulk filling composites. Dental Materials, 2022, 38(2), pp. e19-e30
Salètes M, Vartin M, Mocquot C, Colon P, Chevalier C, Grosgogeat B, Attik N. Mesoporous bioactive glasses cytocompatibility assessment: A review of in vitro studies. Biomimetics, 2021, 6(1), pp.9
Mocquot C, Colon P, Fernando D, Jackson P, Pradelle-Plasse N, Grosgogeat B, Attik N. The influence of experimental bioactive glasses on pulp cells behavior in vitro. Dental Materials, 2020, 36(10), pp.1322-1331
Mocquot C, Attik N, Pradelle-Plasse N, Grosgogeat B, Colon P. Bioactivity assessment of bioactive glasses for dental applications: A critical review. Dental Materials, 2020, 36(9), pp.1116-1143
Lizzi F, Goutaudier C, Attik N, Jackson P, Campbell I, Mokbel I, Grosgogeat B, Villat C. Ion release characterization in phase separated borosilicate glass powders. Journal of Non-Crystalline Solids, 2020, 534, pp.119934
Farano V, Maurin J.C, Attik N, Jackson P, Grosgogeat B, Gritsch K. Sol-gel bioglasses in dental and periodontal regeneration: A systematic review. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2018, 107(4), pp.1210-1227.
Farano V, Cresswell M, Gritsch K, Jackson P, Attik N, Grosgogeat B, Maurin J.C. Bioactivity evaluation of collagen-based scaffolds containing a series of Sr-doped melt-quench derived phosphate-based glasses.Journal of Materials Science: Materials in Medicine, 2018, 29(7).
Fernando D, Colon P, Cresswell M, Journet C, Pradelle-Plasse N, Jackson P, Grosgogeat B, Attik N. The influence of precursor addition order on the porosity of sol–gel bioactive glasses. Dental Materials, 2018, 34(9), pp.1323-1330.
Fernando D, Attik N, Cresswell M, Mokbel I, Pradelle-Plasse N, Jackson P, Grosgogeat B, Colon P. Influence of network modifiers in an acetate based sol-gel bioactive glass system. Microporous and Mesoporous Materials, 2018, 257, pp.99-109.
Lizzi F, Villat C, Attik N, Jackson P, Grosgogeat B, Goutaudier C. Mechanical characteristic and biological behaviour of implanted and restorative bioglasses used in medicine and dentistry: A systematic review. Dental Materials, 2017, 33 (6), pp.702-712.

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Keywords

bioactive glasses
biomaterials
bioactivity
dental
hard tissue
soft tissue
regeneration
preservation
interfaces

Published Papers (3 papers)

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Editorial

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2 pages, 190 KiB

Open AccessEditorial

Bioactive Glass-Based Materials for Soft and Hard Tissue Regeneration: A New Future for Dental and Biomedical Applications

by Nina Attik, Rémy Gauthier and Mohammed Ahmed

Materials 2023, 16(18), 6238; https://doi.org/10.3390/ma16186238 - 15 Sep 2023

Viewed by 671

Abstract

In order to enhance and promote tissue repair and healing processes, current exploratory and investigative research lines in medical and dental treatments are focusing on the use of bioactive materials that are able to induce and trigger a specific targeted biological activity to [...] Read more.

(This article belongs to the Special Issue Bioactive Glass-Based Materials for Soft and Hard Tissue Regeneration: A New Future for Dental and Biomedical Applications)

Research

Jump to: Editorial

15 pages, 10617 KiB

Open AccessArticle

Influence of the Addition of Zinc, Strontium, or Magnesium Oxides to the Bioglass 45S5 Network on Electrical Behavior

by Sílvia Rodrigues Gavinho, Imen Hammami, Suresh Kumar Jakka, Sílvia Soreto Teixeira, Jorge Carvalho Silva, João Paulo Borges and Manuel Pedro Fernandes Graça

Materials 2024, 17(2), 499; https://doi.org/10.3390/ma17020499 - 20 Jan 2024

Viewed by 748

Abstract

45S5 Bioglass has been widely used in regenerative medicine due to its ability to dissolve when inserted into the body. Its typically amorphous structure allows for an ideal dissolution rate for the formation of the hydroxyapatite layer, which is important for the development of new bone. This bioactive capacity can also be controlled by adding other oxides (e.g., SrO, ZnO, and MgO) to the 45S5 Bioglass network or by storing electrical charge. Ions such as zinc, magnesium, and strontium allow for specific biological responses to be added, such as antibacterial action and the ability to increase the rate of osteoblast proliferation. The charge storage capacity allows for a higher rate of bioactivity to be achieved, allowing for faster attachment to the host bone, decreasing the patient’s recovery time. Therefore, it is necessary to understand the variation in the structure of the bioglass with regard to the amount of non-bridging oxygens (NBOs), which is important for the bioactivity rate not to be compromised, and also its influence on the electrical behavior relevant to its potential as electrical charge storage. Thus, several bioactive glass compositions were synthesized based on the 45S5 Bioglass formulation with the addition of various concentrations (0.25, 0.5, 1, and 2, mol%) of zinc, strontium, or magnesium oxides. The influence of the insertion of these oxides on the network was evaluated by studying the amount of NBOs using Raman spectroscopy and their implication on the electrical behavior. Electrical characterization was performed in ac (alternating current) and dc (direct current) regimes. Full article

(This article belongs to the Special Issue Bioactive Glass-Based Materials for Soft and Hard Tissue Regeneration: A New Future for Dental and Biomedical Applications)

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17 pages, 4229 KiB

Open AccessArticle

Correlating the Effect of Composition and Textural Properties on Bioactivity for Pristine and Copper-Doped Binary Mesoporous Bioactive Glass Nanoparticles

by Florestan Vergnaud, Benhur Mekonnen, Abdelouahad El Abbassi, Charlotte Vichery and Jean-Marie Nedelec

Materials 2023, 16(20), 6690; https://doi.org/10.3390/ma16206690 - 14 Oct 2023

Cited by 5 | Viewed by 912

Abstract

Multifunctional substitutes for bone tissue engineering have gained significant interest in recent years in the aim to address the clinical challenge of treating large bone defects resulting from surgical procedures. Sol–gel mesoporous bioactive glass nanoparticles (MBGNs) have emerged as a promising solution due to their high reactivity and versatility. The effect of calcium content on MBGNs textural properties is well known. However, the relationship between their composition, textural properties, and reactivity has not yet been thoroughly discussed in existing studies, leading to divergent conclusions. In this study, pristine and copper-doped binary MGBNs were synthesized by a modified Stöber method, using a cationic surfactant as pore-templating agent. An opposite evolution between calcium content (12–26 wt%) and specific surface area (909–208 m²/g) was evidenced, while copper introduction (8.8 wt%) did not strongly affect the textural properties. In vitro bioactivity assessments conducted in simulated body fluid (SBF) revealed that the kinetics of hydroxyapatite (HAp) crystallization are mainly influenced by the specific surface area, while the composition primarily controls the quantity of calcium phosphate produced. The MBGNs exhibited a good bioactivity within 3 h, while Cu-MBGNs showed HAp crystallization after 48 h, along with a controlled copper release (up to 84 ppm at a concentration of 1 mg/mL). This comprehensive understanding of the interplay between composition, textural properties, and bioactivity, offers insights for the design of tailored MBGNs for bone tissue regeneration with additional biological and antibacterial effects. Full article

(This article belongs to the Special Issue Bioactive Glass-Based Materials for Soft and Hard Tissue Regeneration: A New Future for Dental and Biomedical Applications)

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