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Advances in Biointerfaces
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Advances in Biointerfaces

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: closed (15 July 2016) | Viewed by 23471

Special Issue Editor

Dr. Qun Ren

E-Mail Website
Guest Editor
Laboratory for Biointerfaces, Empa, the Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
Interests: antimicrobial materials; biofilm; bacteria and materials interactions; biosensors for bacterial infections
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biointerfaces, interfaces between materials and biological systems, have been widely studied during the last few decades. The behavior of a given material is strongly dependent on the relevant biological environment. Thus, there has been the urgent need to increase the understanding of interactions between biological systems and surfaces, especially in the fields of biology, biotechnology, biosensors and diagnostics, biomimetic materials, and medical-related biomaterials. Progress in knowledge acquisition has been, and can only be, made by multidisciplinary collaborations among materials scientists, physicists, chemists, biologists, and others.

The Special Issue on "Advances in Biointerfaces" is devoted to giving a contemporary overview of recent developments in this field. Papers addressing fundamental and applied research in the areas of biology and materials science, with particular relevance to the medical, pharmaceutical, biotechnological, food, and cosmetic fields, are strongly encouraged.

It is my pleasure to invite you to submit a manuscript for this Special Issue. Reviews, full-length research manuscripts, and short communications are all welcome.

Dr. Qun Ren
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biofouling
  • biointerfaces
  • in vitro models
  • infectious disease
  • food processing
  • hygine problems
  • antimicrobial interfaces
  • bioinspired interfaces
  • surface properties
  • surface characterization
  • surface engineering
  • biosensors

Published Papers (4 papers)

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Research

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5508 KiB  
Article
Flow Chamber System for the Statistical Evaluation of Bacterial Colonization on Materials
by Friederike Menzel, Bianca Conradi, Karsten Rodenacker, Anna A. Gorbushina and Karin Schwibbert
Materials 2016, 9(9), 770; https://doi.org/10.3390/ma9090770 - 10 Sep 2016
Cited by 9 | Viewed by 5616
Abstract
Biofilm formation on materials leads to high costs in industrial processes, as well as in medical applications. This fact has stimulated interest in the development of new materials with improved surfaces to reduce bacterial colonization. Standardized tests relying on statistical evidence are indispensable [...] Read more.
Biofilm formation on materials leads to high costs in industrial processes, as well as in medical applications. This fact has stimulated interest in the development of new materials with improved surfaces to reduce bacterial colonization. Standardized tests relying on statistical evidence are indispensable to evaluate the quality and safety of these new materials. We describe here a flow chamber system for biofilm cultivation under controlled conditions with a total capacity for testing up to 32 samples in parallel. In order to quantify the surface colonization, bacterial cells were DAPI (4`,6-diamidino-2-phenylindole)-stained and examined with epifluorescence microscopy. More than 100 images of each sample were automatically taken and the surface coverage was estimated using the free open source software g’mic, followed by a precise statistical evaluation. Overview images of all gathered pictures were generated to dissect the colonization characteristics of the selected model organism Escherichia coli W3310 on different materials (glass and implant steel). With our approach, differences in bacterial colonization on different materials can be quantified in a statistically validated manner. This reliable test procedure will support the design of improved materials for medical, industrial, and environmental (subaquatic or subaerial) applications. Full article
(This article belongs to the Special Issue Advances in Biointerfaces)
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3790 KiB  
Article
Screening of Osteogenic-Enhancing Short Peptides from BMPs for Biomimetic Material Applications
by Kei Kanie, Rio Kurimoto, Jing Tian, Katsumi Ebisawa, Yuji Narita, Hiroyuki Honda and Ryuji Kato
Materials 2016, 9(9), 730; https://doi.org/10.3390/ma9090730 - 25 Aug 2016
Cited by 16 | Viewed by 5097
Abstract
Bone regeneration is an important issue in many situations, such as bone fracture and surgery. Umbilical cord mesenchymal stem cells (UC-MSCs) are promising cell sources for bone regeneration. Bone morphogenetic proteins and their bioactive peptides are biomolecules known to enhance the osteogenic differentiation [...] Read more.
Bone regeneration is an important issue in many situations, such as bone fracture and surgery. Umbilical cord mesenchymal stem cells (UC-MSCs) are promising cell sources for bone regeneration. Bone morphogenetic proteins and their bioactive peptides are biomolecules known to enhance the osteogenic differentiation of MSCs. However, fibrosis can arise during the development of implantable biomaterials. Therefore, it is important to control cell organization by enhancing osteogenic proliferation and differentiation and inhibiting fibroblast proliferation. Thus, we focused on the screening of such osteogenic-enhancing peptides. In the present study, we developed new peptide array screening platforms to evaluate cell proliferation and alkaline phosphatase activity in osteoblasts, UC-MSCs and fibroblasts. The conditions for the screening platform were first defined using UC-MSCs and an osteogenic differentiation peptide known as W9. Next, in silico screening to define the candidate peptides was carried out to evaluate the homology of 19 bone morphogenetic proteins. Twenty-five candidate 9-mer peptides were selected for screening. Finally, the screening of osteogenic-enhancing (osteogenic cell-selective proliferation and osteogenic differentiation) short peptide was carried out using the peptide array method, and three osteogenic-enhancing peptides were identified, confirming the validity of this screening. Full article
(This article belongs to the Special Issue Advances in Biointerfaces)
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2486 KiB  
Article
Rapid Assay to Assess Bacterial Adhesion on Textiles
by Sabrina Schmidt-Emrich, Philipp Stiefel, Patrick Rupper, Heinz Katzenmeier, Caroline Amberg, Katharina Maniura-Weber and Qun Ren
Materials 2016, 9(4), 249; https://doi.org/10.3390/ma9040249 - 30 Mar 2016
Cited by 30 | Viewed by 6352
Abstract
Textiles are frequently colonized by microorganisms leading to undesired consequences like hygienic problems. Biocidal coatings often raise environmental and health concerns, thus sustainable, biocide-free coatings are of interest. To develop novel anti-adhesive textile coatings, a rapid, reliable, and quantitative high-throughput method to study [...] Read more.
Textiles are frequently colonized by microorganisms leading to undesired consequences like hygienic problems. Biocidal coatings often raise environmental and health concerns, thus sustainable, biocide-free coatings are of interest. To develop novel anti-adhesive textile coatings, a rapid, reliable, and quantitative high-throughput method to study microbial attachment to fabrics is required, however currently not available. Here, a fast and reliable 96-well plate-based screening method is developed. The quantification of bacterial adhesion is based on nucleic acid staining by SYTO9, with Pseudomonas aeruginosa and Staphylococcus aureus as the model microorganisms. Subsequently, 38 commercially available and novel coatings were evaluated for their anti-bacterial adhesion properties. A poly(l-lysine)-g-poly(ethylene glycol) coating on polyester textile substratum revealed an 80% reduction of bacterial adhesion. Both the coating itself and the anti-adhesive property were stable after 20 washing cycles, confirmed by X-ray analysis. The assay provides an efficient tool to rapidly screen for non-biocidal coatings reducing bacterial attachment. Full article
(This article belongs to the Special Issue Advances in Biointerfaces)
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Review

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16359 KiB  
Review
Protein/Peptide Aggregation and Amyloidosis on Biointerfaces
by Qi Lu, Qiuhan Tang, Yuting Xiong, Guangyan Qing and Taolei Sun
Materials 2016, 9(9), 740; https://doi.org/10.3390/ma9090740 - 30 Aug 2016
Cited by 14 | Viewed by 5862
Abstract
Recently, studies of protein/peptide aggregation, particularly the amyloidosis, have attracted considerable attention in discussions of the pathological mechanisms of most neurodegenerative diseases. The protein/peptide aggregation processes often occur at the membrane–cytochylema interface in vivo and behave differently from those occurring in bulk solution, [...] Read more.
Recently, studies of protein/peptide aggregation, particularly the amyloidosis, have attracted considerable attention in discussions of the pathological mechanisms of most neurodegenerative diseases. The protein/peptide aggregation processes often occur at the membrane–cytochylema interface in vivo and behave differently from those occurring in bulk solution, which raises great interest to investigate how the interfacial properties of artificial biomaterials impact on protein aggregation. From the perspective of bionics, current progress in this field has been obtained mainly from four aspects: (1) hydrophobic–hydrophilic interfaces; (2) charged surface; (3) chiral surface; and (4) biomolecule-related interfaces. The specific physical and chemical environment provided by these interfaces is reported to strongly affect the adsorption of proteins, transition of protein conformation, and diffusion of proteins on the biointerface, all of which are ultimately related to protein assembly. Meanwhile, these compelling results of in vitro experiments can greatly promote the development of early diagnostics and therapeutics for the relevant neurodegenerative diseases. This paper presents a brief review of these appealing studies, and particular interests are placed on weak interactions (i.e., hydrogen bonding and stereoselective interactions) that are also non-negligible in driving amyloid aggregation at the interfaces. Moreover, this paper also proposes the future perspectives, including the great opportunities and challenges in this field as well. Full article
(This article belongs to the Special Issue Advances in Biointerfaces)
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