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Naturally-Derived Biomaterials and Biopolymers
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Naturally-Derived Biomaterials and Biopolymers

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: closed (28 February 2017) | Viewed by 13798

Special Issue Editor

Dr. Elisa Mele

E-Mail Website
Guest Editor
Department of Materials, Loughborough University, Loughborough, UK
Interests: biocompatible and natural polymers for regenerative medicine; nanofibrous wound dressings with antimicrobial activity and enhanced cell proliferation; functional nanocomposites with controlled surface and mechanical properties; microfluidic devices for biological assays and food safety; nanofabrication approaches for polymers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The recent health concerns associated with the side effects of synthetic additives used in pharmacy, cosmetics, agriculture, and food industry have stimulated a consumer demand for natural alternatives. There is, therefore, a growing interest in naturally-derived materials that can replace synthetic counterparts and that possess biological activity, such as antimicrobial, antioxidant, anti-inflammatory, antifungal and anticancer properties. This Special issue will consider articles and reviews on, but not limited to, biopolymers extracted from natural resources (proteins and polysaccharides) and composite materials encapsulating bioactive compounds, for application in medicine, tissue engineering, pharmaceutics, cosmetics, food industry and agriculture.

Dr. Elisa Mele
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bio-macromolecules
  • Natural fibres
  • Bioactive composites
  • Biologically derived materials
  • Natural extracts

Published Papers (2 papers)

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Research

7389 KiB  
Article
Biosynthetic PCL-graft-Collagen Bulk Material for Tissue Engineering Applications
by Piergiorgio Gentile, Kegan McColgan-Bannon, Nicolò Ceretto Gianone, Farshid Sefat, Kenneth Dalgarno and Ana Marina Ferreira
Materials 2017, 10(7), 693; https://doi.org/10.3390/ma10070693 - 23 Jun 2017
Cited by 46 | Viewed by 7560
Abstract
Biosynthetic materials have emerged as one of the most exciting and productive fields in polymer chemistry due to their widespread adoption and potential applications in tissue engineering (TE) research. In this work, we report the synthesis of a poly(ε-caprolactone)-graft-collagen (PCL-g [...] Read more.
Biosynthetic materials have emerged as one of the most exciting and productive fields in polymer chemistry due to their widespread adoption and potential applications in tissue engineering (TE) research. In this work, we report the synthesis of a poly(ε-caprolactone)-graft-collagen (PCL-g-Coll) copolymer. We combine its good mechanical and biodegradable PCL properties with the great biological properties of type I collagen as a functional material for TE. PCL, previously dissolved in dimethylformamide/dichloromethane mixture, and reacted with collagen using carbodiimide coupling chemistry. The synthesised material was characterised physically, chemically and biologically, using pure PCL and PCL/Coll blend samples as control. Infrared spectroscopy evidenced the presence of amide I and II peaks for the conjugated material. Similarly, XPS evidenced the presence of C–N and N–C=O bonds (8.96 ± 2.02% and 8.52 ± 0.63%; respectively) for PCL-g-Coll. Static contact angles showed a slight decrease in the conjugated sample. However, good biocompatibility and metabolic activity was obtained on PCL-g-Coll films compared to PCL and blend controls. After 3 days of culture, fibroblasts exhibited a spindle-like morphology, spreading homogeneously along the PCL-g-Coll film surface. We have engineered a functional biosynthetic polymer that can be processed by electrospinning. Full article
(This article belongs to the Special Issue Naturally-Derived Biomaterials and Biopolymers)
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3988 KiB  
Article
Collagen-Fibrinogen Lyophilised Scaffolds for Soft Tissue Regeneration
by Jennifer Shepherd, Daniel Bax, Serena Best and Ruth Cameron
Materials 2017, 10(6), 568; https://doi.org/10.3390/ma10060568 - 23 May 2017
Cited by 12 | Viewed by 5694
Abstract
A significant body of research has considered collagen as a scaffold material for soft tissue regeneration. The main structural component of extra-cellular matrix (ECM), collagen’s advantages over synthetic polymers are numerous. However, for applications where higher stiffness and stability are required, significant cross-linking [...] Read more.
A significant body of research has considered collagen as a scaffold material for soft tissue regeneration. The main structural component of extra-cellular matrix (ECM), collagen’s advantages over synthetic polymers are numerous. However, for applications where higher stiffness and stability are required, significant cross-linking may affect bioactivity. A carbodiimide (EDC) cross-linking route consumes carboxylate groups that are key to collagen’s essential cell recognition motifs (GxOGER). Fibrinogen was considered as a promising additive as it plays a key role in the process of wound repair and contains RGD integrin binding sites which bind to a variety of cells, growth factors and cytokines. Fibrinogen’s binding sites however, also contain the same carboxylate groups as collagen. We have successfully produced highly interconnected, porous collagen-fibrinogen scaffolds using a lyophilisation technique and micro-computed tomography demonstrated minimal influence of either fibrinogen content or cross-linking concentration on the scaffold structure. The specific biological effect of fibrinogen additions into cross-linked collagen are considered by using films as a model for the struts of bulk scaffolds. By considering various additions of fibrinogen to the collagen film with increasing degrees of cross-linking, this study demonstrates a significant biological advantage with fibrinogen addition across the cross-linking concentrations typically applied to collagen-based scaffolds. Full article
(This article belongs to the Special Issue Naturally-Derived Biomaterials and Biopolymers)
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